mecamylamine_hydrochloride: profile and news

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Other information

Indication
For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

Pharmacology
Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers.

Mechanism Of Action
Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.

Drug Category
Antihypertensive Agents; Nicotinic Receptor Antagonist ATC:C02BB01

Brand Names/Synonyms
Versamine; Inversine; Revertina; Inversine hydrochloride; Mecamilamina; Mecamine; Mecamine hydrochloride; Mecamylamine Hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 2-Norbornanamine, N,2,3,3-tetramethyl-; 2-Norbornanamine, N,2,3,3-tetramethyl-, hydrochloride; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride

Dosage Forms
Tablets

Absorption
Mecamylamine is almost completely absorbed from the gastrointestinal tract

Interactions
Interactions for Mecamylamine: Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers. The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.

Chemical IUPAC Name
N,2,3,3-tetramethylnorbornan-2-amine

Chemical Formula
C11H21N

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00458

CAS Registry Number
60-40-2