enflurane: profile and news

[an error occurred while processing this directive]

Other information

Indication
For use as a Inhalation anaesthetic for general anesthesia and for analgesia for vaginal delivery.

Pharmacology
Enflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. Induction of and recovery from anesthesia with enflurane are rapid. Enflurane has a mild sweet odor. Enflurane may provide a mild stimulus to salivation or tracheobronchial secretions. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia can be changed rapidly by changing the inspired enflurane concentration.

Mechanism Of Action
Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Enflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

Drug Category
Anesthetics; General Anesthetics; ATC:N01AB04

Brand Names/Synonyms
Alyrane; Anesthetic 347; Anesthetic Compound No. 347; C 347; Compound 347; Efrane; Enflurane; Enflurano [Inn-Spanish]; Enfluranum [Inn-Latin]; Ethrane; Methylflurether; Ohio 347

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane

Chemical Formula
C3H2ClF5O

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00234

CAS Registry Number
13838-16-9