biperiden: profile and news

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Other information

Indication
For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Pharmacology
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

Mechanism Of Action
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.

Drug Category
Antiparkinson Agents; Antidyskinetics; Muscarinic Antagonists; Parasympatholytics; ATC:N04AA02

Brand Names/Synonyms
Akineton; Akineton Hydrochloride; Akinophyl; Beperiden; Biperiden; Biperiden Hydrochloride; Biperiden [Usan:Ban:Inn:Jan]; Biperidene Hydrochloride; Biperidene [Inn-French]; Biperideno [Inn-Spanish]; Biperidenum [Inn-Latin]; Biperidine; Biperidine Hydrochloride; CHEMBANK2609; KL 373

Dosage Forms
TABLET

Absorption
87% bioavailability

Interactions
Interactions for Biperiden:

Drug Interactions: The central anticholinergic syndrome can occur when anticholinergic agents such as AKINETON are administered concomitantly with drugs that have secondary anticholinergic actions, e.g., certain narcotic analgesics such as meperidine, the phenothiazines and other antipsychotics, tricyclic antidepressants, certain antiarrhythmics such as the quinidine salts, and antihistamines. See OVERDOSAGE section for signs and symptoms of the central anticholinergic syndrome, and for treatment.

Chemical IUPAC Name
1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol

Chemical Formula
C21H29NO

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00725

CAS Registry Number
514-65-8