Xanax: profile and news






Dolphins DT Traylor facing DUI charge  17 May 2006
...was arrested on misdemeanor counts of driving under the influence of alcohol and illegal possession of the prescription antidepressant Xanax, said Rebecca Young ... - Seattle Post Intelligencer

Three Vernon Parish residents arrested in DeRidder  17 May 2006
...possession of a controlled dangerous substance Schedule II (Soma) and possession of a controlled dangerous substance Schedule IV (Valium and Xanax). ... - Leesville Daily Leader,

Prescription Drugs are Easy for Teens to Get  17 May 2006
...their parents' drug cabinet. They say Xanax is one of the worst prescription drugs being used by teens, because it's so easy to get. - WAWS

World hockey: US beats Czechs  17 May 2006
...tackle Keith Traylor is free on bond after being charged with driving under the influence and illegal possession of a prescription drug (Xanax) in Pryor, Okla ... - Indianapolis Star,

Study: One in five teens have tried prescription painkillers  17 May 2006
In addition to those drugs, other popular prescription drugs being abused in Savannah include Lortab, Xanax, Soma, Adderall and Ritalin. ... - Savannah Morning News,

AROUND SPORTS  17 May 2006
...in Pryor, Okla., on misdemeanor counts of driving under the influence of alcohol and illegal possession of the prescription antidepressant Xanax, said Rebecca ... - Houston Chronicle,

Drink Detective  17 May 2006
...dogs. The next section tests for benzoadiapines like Rohypnol, commonly known as roofies and other drugs like Valium and Xanax. ... - WHO-TV,

Jury finds Nolan guilty By Dave Kucifer Examiner Publisher  17 May 2006
Bender said that Nolan had admitted to spending the day smoking marijuana, drinking beer and taking Xanax prior to the altercation. ... - The Navasota Examiner,

With John Merla, it's one  17 May 2006
To suggest that a patient already receiving huge doses of morphine, OxyContin, oxycodone, Xanax or the like to manage pain will be threatened by a few tokes of ... - Woodbridge Sentinel,

1 in 5 teens has abused painkillers  17 May 2006
...said. Teenagers say they take a range of other people's medicines, including Valium and Xanax to relax and Ambien for sleeping. ... - NorthJersey.com,

Put America on psychiatrist's couch to understand polls  17 May 2006
...handle very well -- fear, insecurity, resentment. It's as if the whole nation needs to be on Xanax. Or already is. In the past I've ... - Indianapolis Star,

Sheriff: Student pushing Xanax at high school  May 12, 2006
Department. What kind of pills? “She identified the pills as ‘zannies,’ which is slang for Xanax,� McGaha says. "She did ... - WHAS 11.com (subscription),

Xanax: Covered or Not Covered?  Apr 19, 2006
Medicare does not cover Benzodiazepines and medicines falling under this category are Serax, Tranxene-SD, Valium, Xanax, Intensol, Paxipam, ProSom, Restoril ... - LiveArticles.org,

Generation Xanax  Apr 23, 2006
23--Xanax bars -- call 'em totem poles or even Tonka toys...I popped half and popped the other half and hit the crown...Then put my shot glass down and poured ... - International News Service,

Generation Xanax  Apr 23, 2006
Xanax bars -- call `em totem poles or even Tonka toys...I popped half and popped the other half and hit the crown...Then put my shot glass down and poured ... - Sun-Sentinel.com,

Sparring again with old medical demons  May 16, 2006
The gentle pressure in my chest must be caused by my head. I took a Xanax for anxiety. The pressure seemed to grow less, but it didn't go away. ... - Boston Globe,

Officials arrest Hardin County's 'largest illegal prescription ...  May 15, 2006
When four officers raided Peeler's home, they found about 10,000 prescription pain killers, including Xanax, Valium and methadone. ... - Beaumont Enterprise,

Parent Q&A: Early intervention will help quell panic attacks  May 16, 2006
Things got so bad we took her to the emergency room. They said she had a panic attack and gave her some Xanax, and also told her to seek counseling. ... - Lansing State Journal,

Generation Xanax  Apr 23, 2006
Xanax bars -- call `em totem poles or even Tonka toys...I popped half and popped the other half and hit the crown...Then put my shot glass down and poured ... - Sun-Sentinel.com,

Narcotics Task Force has busy Friday morning  May 13, 2006
These two containers contained Soma, Valium and Xanax tablets. ... II (Soma's) and possession of a controlled dangerous substance, Sch. IV (Valium's and Xanax's). ... - DeRidder Beauregard Daily News,

St. Patrick school drug incident under investigation  May 9, 2006
The girls had been given Xanax and Methadone by a woman who volunteered in the lunchroom at the school, they told police. According ... - Ledger Independent,

Three charged with possession of cocaine  May 12, 2006
...with dealing over three grams of cocaine within 1,000 feet of a school, a Class A felony; possession of cocaine, a Class D felony; possession of Xanax, a Class ... - Peru Tribune,

Cops: Had 3 drugs on him  May 9, 2006
A Bayonne man was arrested on multiple drug charges Saturday morning, police said, including possession of heroin, Xanax and morphine. ... - The Jersey Journal,

Wabash trio faces drug charges  May 12, 2006
Dutton was charged with dealing more than three grams of cocaine within 1,000 feet of a school, possession of cocaine, possession of Xanax, maintaining a ... - Wabash Plain Dealer,

From Panic to Protest  May 11, 2006
She was prescribed Xanax, but she said she rarely takes it anymore. "Why should I take something that's addicting and distorts your ... - The Spectator,

Slain child's parents face drug charges  May 11, 2006
...reported seeing them give someone at least 400 grams of hydrocodone and more than 28 grams of alprazolam, more commonly known as Xanax, criminal complaints show ... - Houston Chronicle,

Teens swapping legal drugs at `pharming' parties  May 2, 2006
Vicodin. OxyContin. Xanax. All legal drugs destined for illegal use. ... He popped four or five Xanax, washed them down with vodka and was ready to party. ... - Fort Wayne News Sentinel,

Bossier City drug sweep results in dozens of arrests  May 8, 2006
...crystal form of methamphetamine known as "Ice," as well as cocaine (also Schedule II), the Scheduled I CDS marijuana and the drugs Lortab, Xanax, Valium and ... - Shreveport Times,

Document ties Neal's pills to fellow inmates  May 15, 2006
According to the lawsuit pending before Garcia, Neal claims he obtained an unspecified number of Xanax pills from an inmate or guard, ingested about 50 tablets ... - San Antonio Express (subscription),

Prescription drug abuse on the rise  May 15, 2006
...the Willard Hall dorm room of freshman James Michael Lea last weekend and found about 30 prescription pills including Oxycontin, Xanax, Phenobarbital, Ambien ... - 9NEWS.com,

Prescription Drug Bust  May 10, 2006
...communities. In this case, officers say they found the pain medicine hydrozoans and the popular prescribed anti-depressant, Xanax. ... - WTVY,

A memoir and plea from a casual music fan  May 9, 2006
...when I purchase CDs. Every time I step inside an independent music store, no amount of Xanax could assuage my fears. In there are ... - San Diego CityBEAT,

School Worker Arrested For Selling Drugs To Students  May 9, 2006
After being questioned, police said the girls told them that Reed gave them the pills which were identified as Xanax and Methadone. - WCPO,

BEAVER FALLS - Burglary charge  May 12, 2006
Beaver Falls police said Laura Jean Fahey, 44, of 520 Valleyview Road took $572 plus OxyContin and Xanax from the home of Ashley Dhayer, no age given, of 519 ... - Beaver County Times,

Suspected drug dealer caught selling to students  May 12, 2006
...campus Thursday. Police say he was found with 43 Xanax tablets, 10 ounces of marijuana and a list of about 30 students' names. We ... - abc13.com,

Student charged with drug possession  May 12, 2006
...fine if convicted, officials said. HISD police found 43 Xanax tablets and 10 ounces of marijuana, police said. They also found a ... - KHOU (subscription),

Teen Accused of Brutal Houston Attack Says Drugs Made Him Do It  May 3, 2006
David Henry Tuck, 18, told ABC's KTRK that he was high on vodka, cocaine, marijuana and Xanax the night that he and Keith Turner allegedly beat and sodomized a ... - ABC News

Indictment alleges witness threatened  May 5, 2006
...that her involvement in the McFarlin case began in the summer of 2004, when she made about 25 policemonitored purchases of cocaine and Xanax, a tranquilizer ... - Arkansas Democrat-Gazette (subscription),

Holdup becomes suicide attempt  May 3, 2006
NASHUA – A suicidal man held up Brooks pharmacy Tuesday and downed bottles of morphine and Xanax pills that he’d taken at gunpoint, police said. ... - Nashua Telegraph (subscription),

Teen accused of beating and sodomizing teen speaks to Eyewitness ...  May 3, 2006
...tells. He says by the time he and his friends got to the house, he was drunk from vodka and high from Xanax, cocaine and marijuana. ... - abc13.com,

Nashua man survives robbery, suicide attempt  May 3, 2006
Nashua – A city man was in stabile condition a day after he held up a Brooks Pharmacy at gunpoint and ingested 170 morphine and Xanax pills, according to a ... - The Union Leader,

Cops say duo had drugs in their car  May 4, 2006
A Northborough man and Marlborough woman were arraigned yesterday on a host of drug charges after police said they found heroin, cocaine and Xanax stashed in ... - MetroWest Daily News,

Two arrested on drug counts  May 2, 2006
Logan R. Peite, 18, of 313 Copper St., Hurley, and a 16-year-old face counts of possession of Xanax. ... Xanax is in a class of drugs called benzodiazepines. ... - Ironwood Daily Globe,

Police Blotter  May 15, 2006
...and paraphernalia possession charges, and then re-arrested after police again found him in possession of a small amount of marijuana and 13 Xanax tablets while ... - Wilkes Barre Times-Leader,

Kendallville office building burns  May 11, 2006
The stop led to officers’ searching an apartment in the 1900 block of Vernon Street, where they found cocaine, marijuana and Xanax. ... - Fort Wayne Journal Gazette,

Clay deputies arrest woman in 2005 fatality  May 13, 2006
...an officer's report. She also told an officer she had taken medication, including Xanax and Tylenol with Codeine. Robbers stole ... - Gainesville Sun,


Other information


Indication
For the treatment or management of panic disorder, with or without agoraphobia

Pharmacology
Alprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and yields metabolites with minimal activity. Like other triazolo benzodiazepines such as triazolam, alprazolam may have significant drug interactions involving the hepatic cytochrome P-450 3A4 isoenzyme.

Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing membrane that prevents further excitation of the cell.

Drug Category
Anti-anxiety Agents; Hypnotics and Sedatives; Benzodiazepines; GABA Modulators;

Brand Names/Synonyms
Alplax; Alprazolam; Alpronax; Bestrol; Cassadan; Constan; D 65MT; Esparon; Frontal; Intensol; Niravam; TUS-1; Tafil; Trankimazin; Tranquinal; Xanax; Xanax Xr; Xanor

Dosage Forms
TABLET

Absorption
Following oral administration Benzodiazepines are well absorbed from the gastrointestinal tract, usually within 1 to 2 hours. Following intramuscular administration _ Lorazepam absorption is rapid and complete, whereas chlordiazepoxide and diazepam absorption may be slow and erratic, depending upon the site of administration . When diazepam is injected into the deltoid muscle, absorption is usually rapid and complete . Following rectal administration _ Absorption of diazepam rectal solution and rectal gel is rapid.

Interactions
-->Interactions for Alprazolam:

The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.

The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of alprazolam tablets in doses up to 4 mg/day. The clinical significance of these changes is unknown.

Drugs That Inhibit Alprazolam Metabolism Via Cytochrome P450 3A: The initial step in alprazolam metabolism is hydroxylation catalyzed by cytochrome P450 3A (CYP 3A). Drugs which inhibit this metabolic pathway may have a profound effect on the clearance of alprazolam .

Drugs Demonstrated to be CYP 3A Inhibitors of Possible Clinical Significance on the Basis of Clinical Studies Involving Alprazolam (caution is recommended during coadministration with alprazolam):

Fluoxetine: Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased half-life by 17%, and decreased measured psychomotor performance.
Propoxyphene: Coadministration of propoxyphene decreased the maximum plasma concentration of alprazolam by 6%, decreased clearance by 38%, and increased half-life by 58%.
Oral Contraceptives: Coadministration of oral contraceptives increased the maximum plasma concentration of alprazolam by 18%, decreased clearance by 22%, and increased half-life by 29%.

Drugs and other substances demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to alprazolam or on the basis of in vitro studies with alprazolam or other benzodiazepines (caution is recommended during coadministration with alprazolam): Available data from clinical studies of benzodiazepines other than alprazolam suggest a possible drug interaction with alprazolam for the following: diltiazem, isoniazid, macrolide antibiotics such as erythromycin and clarithromycin, and grapefruit juice. Data from in vitro studies of alprazolam suggest a possible drug interaction with alprazolam for the following: sertraline and paroxetine. Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine. Caution is recommended during the coadministration of any of these with alprazolam.



Chemical IUPAC Name
8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Chemical Formula
C17H13ClN4

Half Life
6.3-26.9 hours (average = 11.2 hrs)

Drug Type
Approved Drug

# Accession No
APRD00280

CAS Registry Number
28981-97-7

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