Wellbutrin: profile and news

I'm Bipolar Journal: December 2005-January 2006  17 May 2006
I saw my psychiatrist on the 11th and started taking 150 mg Wellbutrin that day, with permission to go up to 300. We cut Seroquel back to 150 at the same time. ... - About - News & Issues,

Policies on mentally troubled troops questioned  17 May 2006
Paul Scaglione, 23, an Army mechanic from the Detroit area, said he was put on Wellbutrin in 2003. "It was no big deal," he said. ... - Baltimore Sun,

Biovail 1st-Qtr Profit Rises Sixfold on Wellbutrin (Update3)  May 11, 2006
...publicly traded drugmaker, said first-quarter profit climbed almost sixfold as labor costs declined and sales of the antidepressant Wellbutrin XL increased. ... - Bloomberg

Biovail 1st-Qtr Profit Rises Sixfold on Wellbutrin (Update1)  May 11, 2006
...largest publicly traded drugmaker, said first-quarter profit rose almost sixfold as labor costs declined and sales of the antidepressant Wellbutrin XL increased ... - Bloomberg

Biovail Q1 Earnings Surge On Strong Sales Of Antidepressant ...  May 11, 2006
...results for the first quarter, reporting profit that rose nearly six fold on strong sales of its lead product, the antidepressant Wellbutrin XL, helping the ... - Trading Markets,

Biovail Reports First-Quarter 2006 Financial Results; Company ...  May 11, 2006
In January 2006, Biovail's New Drug Submission for Wellbutrin(R) XL received approval from the Therapeutic Products Directorate (Canada) for the treatment of ... - Genetic Engineering News,

Biovail seeks acquisitions after US$64.5M Q1 profit driven by ...  May 11, 2006
...in US dollars, said it earned $64.5 million, 40 cents per share, in the quarter on strong sales of its key drug, the one-pill-a-day antidepressant Wellbutrin XL ... - CBC News,

Biovail profit soars on strong sales, cost cuts  May 11, 2006
...quarter earnings roared 480 percent higher as Canada's biggest publicly traded drugmaker notched bigger sales for its key anti-depressant, Wellbutrin XL, and ... - Reuters Canada,

Biovail Faces Generic Competition  May 12, 2006
Revenues from strong sales of its lead product, Wellbutrin XL, helped Biovail (nyse: BVF - news - people ) meet or beat street estimates. ... - Forbes

Biovail Sales Surge  May 11, 2006
Biovail (BVF:NYSE - commentary - research - Cramer's Take) beat first-quarter targets as sales of antidepressant Wellbutrin XL surged. ... - TheStreet.com

Biovail 1Q profit up nearly sixfold  May 11, 2006
...said Thursday that its first-quarter profit rose nearly sixfold on strong sales of its lead product, the antidepressant Wellbutrin XL, helping the Canadian ... - BusinessWeek

Morgan Stanley Keeps Glaxo Overweight  May 12, 2006
Notes that a summary judgment in the case of Biovail (BVF.NYS) against Anchen about GSK's antidepressant Wellbutrin XL, has been delayed indefinitely. ... - newratings.com

TO THE POINT  May 11, 2006
Revenue rose 27% to $221 mil. Sales of the antidepressant Wellbutrin leapt 77% to $65 mil. ... Biovail is seeking approval to sell Wellbutrin in Germany. ... - Investor's Business Daily (subscription)

FDA approves Pfizer's smoking-cessation drug  May 11, 2006
...now, smokers seeking to quit have had to generally rely on nicotine-based products, such as gums and patches, or the anti-depressant Wellbutrin, also marketed ... - MarketWatch

Anti-smoking pill is approved  May 12, 2006
...nicotine-free. In 1997, the FDA approved bupropion, an antidepressant sold as Wellbutrin but then rebranded as Zyban. Varenicline ... - The Herald,

UPDATE 1-Biovail first-quarter profit soars, sales up  May 11, 2006
...traded drugmaker, said on Thursday that first-quarter earnings surged as sales jumped 27 percent amid stronger demand for its key anti-depressant Wellbutrin XL ... - Reuters

FDA gives green light to Pfizer drug for quitting smoking  May 11, 2006
Bupropion, an antidepressant marketed under the brand names Wellbutrin and Zyban by GlaxoSmithKline, was the first medication the FDA approved for smoking ... - TODAYonline,

FDA Approves New Smoking-Cessation Aid 10 Weeks After Rejecting ...  May 11, 2006
The last smoking-cessation aid approved by the FDA that was nicotine free was bupropion, an antidepressant already sold as Wellbutrin but approved by the FDA ... - Acomplia Report,

Pfizer drug helps quit the habit  May 12, 2006
In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but rebranded it as Zyban, an anti-smoking drug. - Toronto Sun,

Biovail Q1 profit tops expectations  May 11, 2006
...said it made $64.5 million US (40 cents a share) in the quarter on revenue of $220.5 million on strong sales of its once-a-day Wellbutrin XL antidepression drug ... - CBC Ottawa,

Biovail posts robust 1Q results  May 11, 2006
...trimming of its workforce. The sales of the company’s antidepressant, Wellbutrin, increased 77% during the three-month period. - newratings.com

Big quarter for Biovail  May 11, 2006
The Canadian-based pharmaceuticals company reported today that its first-quarter earnings jumped 480% on strong sales of anti-depressant drug Wellbutrin XL and ... - Ottawa Sun,

Biovail Profit Skyrockets - Eyes Acquisitions  May 11, 2006
Biovail made $64.5-million dollars, as sales of its core products such as the antidepressant Wellbutrin XL improved. According to ... - 580 CFRA Radio,

Eight ways for Salt Lake Real to raise money for a new soccer ...  May 10, 2006
Sandy. 6. Finally make that tough corporate-sponsorship decision: “Hot Pocket Stadium� or “Wellbutrin Arena.�. 5. Organize ... - Salt Lake City Weekly,

Pfizer scores OK for new anti-smoking pill  May 12, 2006
...been shown to nearly double the likelihood of a smoker finally stubbing out than GlaxoSmithKline's Zyban (bupropion), an antidepressant also sold as Wellbutrin ... - Pharma Times (subscription),

Laguna 'stepped out of his body'  May 5, 2006
When he came into the jail, Burrows said Laguna was taking Wellbutrin and Celexa, Ceroquel, for schizophrenia. ... He was also taking Wellbutrin twice a day. ... - Ironwood Daily Globe,

On the Radar: Biovail  May 13, 2006
...companies or generic firms such as Anchen Pharmaceuticals, which is seeking approval for generic versions of BVF's key anti-depressant product Wellbutrin XL. - Reuters

FDA OKs Pfizer Anti-Smoking Pill  May 11, 2006
In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but rebranded it as Zyban, an anti-smoking drug. ... - FOX News

TSX slips on lower financial, tech stocks while NY falls on Fed ...  May 11, 2006
...developer recorded a large jump in first-quarter profits to $64.5 million US as sales of its core products such as the antidepressant Wellbutrin XL improved. ... - CBC News,

Canadian Stocks Fall as Inflation Concerns Weigh on Financials  May 11, 2006
...almost sixfold to $64.5 million, or 40 cents a share, from $11.1 million, or 7 cents, as labor costs declined and sales of antidepressant Wellbutrin XL surged. ... - Bloomberg

Canadian Stocks Fall as Inflation Concerns Weigh on Financials  May 11, 2006
...or 40 cents a share, from $11.1 million, or 7 cents, as labor costs declined on job cuts in the US, and sales of the antidepressant Wellbutrin XL surged 77 ... - Bloomberg

Canadian Stocks Fall as Inflation Concerns Weigh on Market  May 11, 2006
...sixfold. Profit increased to 40 cents a share from 7 cents as labor costs declined and sales of antidepressant Wellbutrin XL surged. ... - Bloomberg

Toronto stocks set to bounce back on resources  May 11, 2006
Biovail Corp. (BVF.TO: Quote) reported a higher first-quarter profit, lifted by robust sales amid stronger demand for its key anti-depressant Wellbutrin XL. ... - Reuters Canada,

New drug could help smokers  May 12, 2006
...treatment with Chantix, abstinence rates were 22 percent compared with 16 percent among those given Zyban, a rebranded version of the antidepressant Wellbutrin ... - Sun-Sentinel.com,

BlackBerry set for China debut  May 11, 2006
Biovail said it earned $64.5 million US, 40cents per share, in the quarter on strong sales of its key drug, the one-pill-a-day antidepressant Wellbutrin XL. ... - Ottawa Sun,

Ex-phenom hits back at IMG, father in bid to regain her game  May 9, 2006
...to the legal source, Ambler also will contend that IMG sent Mirjana to a psychiatrist, who put her on the anti-depressant medication, Wellbutrin, against her ... - San Jose Mercury News,

Drugs giants hit heights on forecast-beating Q1 results  Apr 27, 2006
...to uncertainty over the risk of generic competition to anti-nausea drug Zofran, as well as continuing litigation over patents on antidepressant Wellbutrin XL. ... - Scotsman,

Highlights of rising and falling US stocks  May 11, 2006
The Toronto-based drug company said it saw strong performances from several product lines, including Wellbutrin XL, Legacy products, and its generic portfolio. ... - Investor's Business Daily (subscription)

DTC Takes a Back Seat  May 10, 2006
...year. This figure represents a decrease of 0.4% compared with 2004. Wellbutrin XL’s ranking jumped four spots to No. 10 in 2005. ... - Med Ad News (subscription),

Classen defense continues to make its case  Apr 18, 2006
...due to mental illness. Julien said Classen was taking two antidepressants, Wellbutrin and Serzone. Those targeted the depression ... - The Columbian,

New drug wins approval in fight against smoking  May 11, 2006
...inhaler form. In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but then rebranded as Zyban. Several ... - Deseret News,

FDA approves Pfizer stop-smoking pill  May 12, 2006
...form. In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but renamed it Zyban, an anti-smoking drug. ... - Bradenton Herald,

FDA approves new anti-smoking drug  May 11, 2006
...form. In 1997, the FDA approved bupropion, an antidepressant sold as Wellbutrin but rebranded as Zyban, as an anti-smoking drug. ... - commercialappeal.com (subscription),

'Teachable' 9/11 Moment Helped Smokers Quit  May 1, 2006
Long-acting Wellbutrin, an antidepressant useful in smoking cessation, was also available, but only a few people chose to use it. ... - New York Times,

Generic Pharma Firms Stand To Benefit From Patent Expirations ...  May 8, 2006
While antidepressants like GlaxoSmithKline's Wellbutrin XL and Pfizer's Zoloft are expected to lose patent protection this year, Merck's heart disease drug ... - Trading Markets,

Trial asks 'why?'  May 3, 2006
He was taking Celexa, Wellbutrin, Ceroquel, for schizophrenia, and Xanex. Laguna also has been diagnosed with a bi-polar disorder. ... - Ironwood Daily Globe,

Suspect suicidal, says therapist  May 5, 2006
White, a psychiatrist from Rhinelander, increased Laguna's dosage of Celexa from 40 milligrams to 60 milligrams and also put him on Wellbutrin in November 2004 ... - Ironwood Daily Globe,

Laguna trial begins  May 1, 2006
He was taking Celexa, Wellbutrin, Ceroquel, for schizophrenia, and Xanex. Incarcerated since March 16, 2005, Laguna has been weaned off the medications. ... - Ironwood Daily Globe,

Buried Sacrifice: Inside the Military Family  May 3, 2006
...and post-traumatic stress disorder. They include brand names such as Paxil, Cymbalta and Wellbutrin." [Source]. "The US Bureau of ... - Political Cortex,

Few systemic data have been collected on the metabolism of WELLBUTRIN following concomitant administration with other drugs or, alternatively, the effect of concomitant administration of WELLBUTRIN on the metabolism of other drugs.

Because bupropion is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that bupropion is primarily metabolized to hydroxybupropion by the CYP2B6 isoenzyme. Therefore, the potential exists for a drug interaction between WELLBUTRIN and drugs that affect the CYP2B6 isoenzyme (e.g., orphenadrine and cyclophosphamide). The threohydrobupropion metabolite of bupropion does not appear to be produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of bupropion and its active metabolites were studied in 24 healthy young male volunteers. Following oral administration of two 150-mg sustained-release tablets with and without 800 mg of cimetidine, the pharmacokinetics of bupropion and hydroxybupropion were unaffected. However, there were 16% and 32% increases in the AUC and C_max, respectively, of the combined moieties of threohydrobupropion and erythrohydrobupropion.

While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine, phenobarbital, phenytoin).

Animal data indicated that bupropion may be an inducer of drug-metabolizing enzymes in humans. In one study, following chronic administration of bupropion, 100 mg 3 times daily to 8 healthy male volunteers for 14 days, there was no evidence of induction of its own metabolism. Nevertheless, there may be the potential for clinically important alterations of blood levels of coadministered drugs.

Drugs Metabolized by Cytochrome P450IID6 (CYP2D6): Many drugs, including most antidepressants (SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics are metabolized by the CYP2D6 isoenzyme. Although bupropion is not metabolized by this isoenzyme, bupropion and hydroxybupropion are inhibitors of the CYP2D6 isoenzyme in vitro. In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C_max, AUC, and t_1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively. The effect was present for at least 7 days after the last dose of bupropion. Concomitant use of bupropion with other drugs metabolized by CYP2D6 has not been formally studied.

Therefore, co-administration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution and should be initiated at the lower end of the dose range of the concomitant medication. If bupropion is added to the treatment regimen of a patient already receiving a drug metabolized by CYP2D6, the need to decrease the dose of the original medication should be considered, particularly for those concomitant medications with a narrow therapeutic index.

MAO Inhibitors: Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine .

Levodopa and Amantadine: Limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine. Administration of WELLBUTRIN Tablets to patients receiving either levodopa or amantadine concurrently should be undertaken with caution, using small initial doses and small gradual dose increases.

Drugs that Lower Seizure Threshold: Concurrent administration of WELLBUTRIN and agents (e.g., antipsychotics, other antidepressants, theophylline, systemic steroids, etc.) that lower seizure threshold should be undertaken only with extreme caution. Low initial dosing and small gradual dose increases should be employed.

Nicotine Transdermal System: .

Alcohol: In post-marketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with WELLBUTRIN. The consumption of alcohol during treatment with WELLBUTRIN should be minimized or avoided (also see CONTRAINDICATIONS).

 


Chemical IUPAC Name
1-(3-chlorophenyl)-2-tert-butylamino-propan-1-one

Chemical Formula
C13H18ClNO

Half Life
24 hours

Drug Type
Approved Drug

# Accession No
APRD00621

CAS Registry Number
34841-39-9