Vitamin_B2_(Riboflavin): profile and news

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Other information

Indication
Used in the treatment of ariboflavinosis (vitamin B2 deficiency).

Pharmacology
Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.

Mechanism Of Action
Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.

Drug Category
ATC:A11HA04; Radiation-Sensitizing Agents; Vitamins (Vitamin B Complex)

Brand Names/Synonyms
Aqua-Flave; Beflavin; Beflavine; Bisulase; CCRIS 1904; Dermadram; Fiboflavin; Flavaxin; Flavin; Flavin Bb; Flaxain; Fmm-Na.2h2o; HSDB 817; Hyflavin; Hyre; Lactobene; Lactoflavin; Lactoflavine; Lactoflavine, Zinvit-G; Ovoflavin; Q 14; Ribipca; Ribocrisina; Riboderm; Riboflavin; Riboflavin [Usan:Inn:Jan]; Riboflavin for Biochemistry; Riboflavin, 98%; Riboflavina [Inn-Spanish]; Riboflavine; Riboflavine [Inn-French]; Riboflavinequinone; Riboflavinum [Inn-Latin]; Ribosyn; Ribotone; Ribovel; Russupteridine Yellow Iii; Vitaflavine; Vitamin B2; Vitamin B2 Feed Grade; Vitamin Bi; Vitamin G; Vitasan B2

Dosage Forms
Injection and oral

Absorption
Vitamin B2 is readily absorbed from the upper gastrointestinal tract.

Interactions
Interactions for Vitamin B2 (Riboflavin): Alcohol - impairs the intestinal absorption of riboflavin Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications. Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.

Chemical IUPAC Name
Not Available

Chemical Formula
C17H20N4O6

Half Life
66-84 minutes

Drug Type
Approved Drug

# Accession No
APRD00626

CAS Registry Number
83-88-5