Viagra: profile and news

SEEK a Liitle Relationship Help From Viagra  17 May 2006
Sadly many thousands of people each year decide to end their marriage or relationships without seeking professional sexual advice or a liitle help from Viagra. ... - LiveArticles.org,

Viagra tops list of fake drugs  17 May 2006
Abu Dhabi: An increasing number of pharmacies are selling counterfeit drugs, with erectile dysfunction drug Viagra topping the list, health officials said. ... - Gulf News,

Viagra- Unsurprisingly the Champ  17 May 2006
But a very few have satisfied to its recipient. And to top the list is the oral prescription drug Viagra which has deal with impotence like a magical baton. ... - LiveArticles.org,

Beware! Fake sex drugs on sale, warns company  17 May 2006
...manager. Trade in counterfeit sex performance drugs, Cialis and Viagra, is very brisk especially those imported from China and India. ... - Daily Nation (subscription),

Mark Ritson on branding: Pfizer trial reveals brand malady  17 May 2006
Pfizer. The world's biggest pharmaceutical corporation has recently launched some very successful drugs, including Lipitor and Viagra. ... - Design Bulletin,

One man, 353 commercials, no remote  17 May 2006
No whistling here today. 11:29: Here are the made-in-Canada Viagra ads that have already won at award shows around the world. In ... - Globe and Mail,

Viagra and the wine blogosphere  May 15, 2006
Yes, blogging is intimidating for the uninitiated. That’s why I’m proposing that Stormhoek has stumbled upon the Viagra of the wine industry. ... - South African Wine News,

Viagra creating a dizzy spell in the world of male impotency  May 14, 2006
Viagra has become the next common thing today for men with ED. When we have Bob Dole openly sharing the secret impotency no longer ... - LiveArticles.org,

Fake Viagra maker given 10-year prison term  May 9, 2006
A total of 381,000 fake Viagra pills and 1.4 million counterfeit Cialis tablets, worth a combined total of 241 million yuan (US$29 million) on the market, were ... - Xinhua,

An effort to entice cures for diseases  May 15, 2006
It’s still pretty rich because blockbuster drugs such as Viagra, a popular anti-impotence drug, can be worth more than $1 billion a year, said Richard Frank ... - Kansas City Star,

Enrich Life with Erectile Dysfunction Drug's Viagra and Cialis  May 11, 2006
We shall now enrich your life FAST by sharing with you information about the erectile dysfunction drug's viagra and Cialis (tadalafil). ... - LiveArticles.org,

What can Viagra do for you?  May 10, 2006
Pfizer’s Viagra was one of the foremost ED treatment drugs, which revolutionized the field. Today, more than 16 million men have ... - LiveArticles.org,

Fake Chinese Viagra maker sentenced to 10-year prison term  May 10, 2006
A total of 381,000 fake Viagra pills and 1.4 million counterfeit Cialis tablets, worth a combined total of 241 million yuan (USD 29 million) on the market ... - NewKerala.com,

Fake Viagra  May 9, 2006
A BUSINESSMAN was sentenced to 10 years for producing fake Viagra and Cialis pills with a market value of 241 million yuan (US$30.1 million) in Shaoxing ... - Shanghai Daily,

Back to the First Time You ever heard of Viagra  May 12, 2006
Think back to the first time you ever heard of Viagra. At first glance Pfizer's Viagra may seem unenchanting, however its study ... - LiveArticles.org,

Proof of Viagra Use Rebuts Wife's Claim of Abandonment  May 13, 2006
...the proof was in the pill box: GW elicited as evidence of his and his wife CW's lovemaking his physician's testimony that he had taken Viagra and, purportedly ... - Texas Lawyer (subscription),

Brazilian court eases Viagra's firm grip on market  May 11, 2006
A Brazilian court authorized the open production and sale of medications to treat erectile dysfunction in men, loosening Viagra's firm grip on the market ... - TODAYonline,

Levitra, Viagra launch new ad campaigns  May 2, 2006
Levitra and Viagra now have new campaigns that forego the provocative in favor of depicting erectile dysfunction as a medical condition, not simply a lifestyle ... - BusinessWeek

Younger Men Using Viagra Without Prescription, Survey Reveals  May 1, 2006
By Miranda Hitti. Some young men experience erection problems and take erectile dysfunction drugs without a doctor’s prescription. ... - FOX News

Levitra, Viagra Launch New Ad Campaigns  May 2, 2006
Viagra‘s new ad, launched on Monday, leads with a frisky couple, then a doctor surfaces to explain the drug‘s risk and benefits. ... - Olberlin,

Potential new usage for Viagra  May 1, 2006
In a recently published medical review, a London-based cardiologist argues that Pfizer’s Viagra pill, once thought only to be the savior of impotent men, may ... - Trade Arabia,

Viagra plus recreational drugs equals risky sexual behaviour  May 1, 2006
A new survey has found that a significant number of young men have used erectile dysfunction, (ED), medications such as Viagra often in conjunction with other ... - News-Medical.net,

Study finds young men having erectile dysfunction ...  May 1, 2006
...that normally afflicts older men, can be a problem among young males too and there is evidence of increasing use among them of drugs like Viagra along with ... - Earthtimes.org

Viagra-firm lobbyist to stand for Labour in Blaenau Gwent  May 8, 2006
A FORMER TV producer who now is a senior lobbyist for the drugs firm that produces Viagra will be standing for Labour in the Blaenau Gwent parliamentary by ... - ic Wales,

Viagra is sexy again  May 8, 2006
Viagra is looking to have the best of both worlds with a new television spot that's been created by McCann Erickson. The spot starts ... - AdJab,

Viagra college  May 3, 2006
Thousands of college age men are using Viagra and other drugs to have sex. The commercials are aimed at older men. But drugs like ... - WHDH-TV,

Pfizer Unveils Next Generation Viagra Spot  May 4, 2006
NEW YORK Pfizer began rolling out a new series of spots for its erectile dysfunction drug Viagra this week, focusing not only on the product's efficacy, but ... - Adweek,

Spark your sexual life with Viagra  May 4, 2006
So, is there a way out? Yes. Viagra! ... (www.rxlist.com) Translated to English, Viagra or the magic blue pill is the sacred grail for everyone suffering from ED. ... - LiveArticles.org,

SATISFACTION in the Bedroom with Viagra  May 8, 2006
Satisfaction between men and women who use Viagra may boost sex lives, American researchers have reported. The study learnt that ... - LiveArticles.org,

Ayoon Wa Azan(Viagra or PhD?)  May 1, 2006
I received an e-mail trying to persuade me to buy Viagra. We all know something about Viagra. But the e-mail or the ad included ... - Dar Al-Hayat,

ANGER IS RISING OVER HONCHO'S VIAGRA QUIP  May 3, 2006
...startled some officials attending a Hispanic legislators' conference in Albany last weekend with a bawdy joke about Hispanic men not needing Viagra, The Post ... - New York Post,

Viagra may help children with fatal lung disorder  May 8, 2006
Physicians at The Hospital for Sick Children (SickKids) have found that the drug sildenafil, also known as Viagra, may help children suffering from pulmonary ... - Hospital News,

Poor performance not curable with Viagra  May 3, 2006
Symptoms include sleepless nights, aggression, over or under eating, memory loss, alopecia and impotence and yet - very little is done to lessen the pressure ... - Contractor UK,

Pfizer Faces Viagra Suits Over Users' Vision Loss  Apr 19, 2006
Pfizer Inc. is defending itself in court against Viagra users who claim the drug caused them to lose their vision. At least 17 cases ... - Los Angeles Times,

Cinematic Viagra struggles to prop up flagging plot  Apr 26, 2006
...and Moore are not going to drop the ball, so whenever they appear in a bad film it's impossible to view them as anything more than cinematic Viagra used to ... - Scotsman,

Viagra peddlers can expect stiff sentence  Apr 19, 2006
TWO MEN have been jailed after they were caught running a huge illegal pharmacy network peddling Viagra online. Akhil Bansal and ... - Inquirer,

Ensure Quality Sexual Health with Viagra  Apr 19, 2006
...years back doctors were in the warning mode saying that, unless the government issues guidelines on the prescription of impotence wonder drug Viagra, it will ... - LiveArticles.org,

Viagra Goes to Court – l  Apr 19, 2006
Around this time last year, the Federal drug investigators were looking into reports that Viagra, the erectile dysfunction drug may have resulted in an adverse ... - LiveArticles.org,

Some visually impaired men shouldn't take Viagra, panel says  Apr 28, 2006
...from vision loss in one eye because of a common optic nerve disease shouldn't use certain impotence drugs including Pfizer Inc.'s Viagra, according to a ... - Arizona Republic,

Viagra Goes to Court – ll  Apr 19, 2006
...come back. But I've also pretty much accepted that Viagra done it.". It ... His unholy alliance with Viagra has backfired. Little wonder, his ... - LiveArticles.org,

The Blessed Viagra!  Apr 26, 2006
Is that why God blesses us with Viagra? ... Viagra answers to that question of self-respect and self-esteem to man, giving his sexual strength and prowess back. ... - LiveArticles.org,

Generic Viagra suiting a common man’s purse  Apr 26, 2006
Ever since the discovery of the magical sildenafil citrate, Viagra has been ruling the market share and solving sexual dysfunction for millions of men facing ... - LiveArticles.org,

General Motors Spending $17 Million a Year on Viagra and Other " ...  Apr 17, 2006
Our candidate for an Onion headline: "GM Launches New Brand Image Campaign." (Photo courtesy of Viagra). DETROIT — General Motors ... - Edmunds.com/Inside Line,

GM Spends $17 Million Per Year on Viagra  Apr 18, 2006
Lifestyle drugs -- chiefly Viagra -- are costing General Motors $17 million dollars a year and the cost is passed along to car, truck and SUV consumers. ... - Consumer Affairs

Viagra to go legit in Pakistan soon  Apr 28, 2006
Islamabad: Viagra will soon be available at medical shops in Pakistan, as the country’s Federal Health Ministry is considering to register and regularise the ... - NewKerala.com,

YourLife: How Viagra is Helping to Keep Me Alive ; HEALTH: One ...  Apr 17, 2006
WHEN Kirsty Boswell tells people she is on Viagra she is usually greeted with sniggers. But for the 30-year-old it's no laughing matter. ... - International News Service,

GM Spends $17 Million On Employee Viagra  Apr 18, 2006
Viagra, Cialis and other erectile dysfunction drugs are costing General Motors Corp. a hefty sum. The company spends $17 million ... - WDTN,

Walking In The Search Engines’ Shoes  May 15, 2006
One of the keyword phrases we chose was Viagra. ... You have to assume that some people who put "viagra" into the search box are looking to buy the product. ... - WebProNews,

Sack-happy Canucks prop up Viagra  Apr 22, 2006
The true winner from the survey, apart from the California Governor's fellow countrymen, is Pfizer, the maker of impotence drug Viagra, which got thousands of ... - Globe and Mail,

Effects of Other Drugs on Sildenafil Citrate

In Vitro Studies: Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance.

In Vivo Studies: Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma sildenafil concentrations when coadministered with sildenafil citrate (50 mg) to healthy volunteers.

When a single 100 mg dose of sildenafil citrate was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in sildenafil systemic exposure (AUC). In addition, coadministration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with sildenafil citrate (100 mg single dose) resulted in a 140% increase in sildenafil C_max and a 210% increase in sildenafil AUC. Sildenafil citrate had no effect on saquinavir pharmacokinetics. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole would be expected to have still greater effects, and population data from patients in clinical trials did indicate a reduction in sildenafil clearance when it was coadministered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine).

Coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (400 mg bid) with sildenafil citrate (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil C_max and a 1000% (11-fold) increase in sildenafil plasma AUC. At 24 hours the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone. This is consistent with ritonavir's marked effects on a broad range of P450 substrates. Sildenafil citrate had no effect on ritonavir pharmacokinetics.

It can be expected that concomitant administration of CYP3A4 inducers, such as rifampin, will decrease plasma levels of sildenafil.

Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of sildenafil citrate.

Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.

Effects of Sildenafil Citrate on Other Drugs

In Vitro Studies: Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 mM). Given sildenafil peak plasma concentrations of approximately 1 mcM after recommended doses, it is unlikely that sildenafil citrate will alter the clearance of substrates of these isoenzymes.

In Vivo Studies: When sildenafil citrate 100 mg oral was coadministered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic.

No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.

Sildenafil citrate (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg).

Sildenafil citrate (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08%.

Sildenafil (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.