Versed: profile and news






OPINION: I'm no cheat on fairway ... not as a rule  17 May 2006
The bottom line is I'm not well versed in rules and, consequently, relinquish any rights to argue my case. Ignorance of rules can never be a defence. ... - Hawke's Bay Today,

Wuerl's successor faces church heading into thin years  17 May 2006
Along with the crisis in vocations, Father Almade worries, too, about keeping adult Catholics versed in the principles of their religion -- one currently ... - Pittsburgh Post Gazette,

Sherwood Survives  17 May 2006
...counterterrorism credentials. He is better versed in the intricacies of foreign policy than many other Dem vet candidates. Republicans ... - National Journal,

Regulatory Compliance Now Impacts Customer Support Industry  17 May 2006
...the courts. For this reason, support executives must be well versed in data storage, a language previously foreign to them. The ... - TMCnet

Nigeria: Justice Acholonu's Death, Strange - Belgore  17 May 2006
...of West African Bar Association (WABA), Mr Femi Falana said of Justice Pats-Acholonu thus: "he was of the intellectual bend who was very versed in civil liberty ... - AllAfrica.com,

Golf grooming  17 May 2006
For roughly $18, money that goes back into the community ed program, the kids are bused to the course to be versed by coaches – and sometimes a visiting golf ... - In-Forum (subscription),

Celebrity Charitable Organization Enforces Its Rights Against ...  17 May 2006
Focusing exclusively on intellectual property law, the firm is well versed in all aspects of trademarks, copyrights, patents, trade secret, unfair competition ... - PR Web (press release),

Hopefuls audition for Universal Studios tour  17 May 2006
...idle for a minute or two. That means they must be able to improvise and be versed in pop culture. "There are so many qualities we ... - Long Beach Press-Telegram,

Women, Wisdom & Wealth: Investing is not so different than other ...  17 May 2006
If you're not big on reading, spend time with people who are well versed and well read on the subject of finances. Ask them questions. ... - Naples Daily News (subscription),

Opens Friday at Shaker Square Cinemas  17 May 2006
...stash. To replace the victuals, he rallies his woodland pals, all of whom are well-versed in the art of scavenging. Unfortunately ... - Cleveland Free Times,

The Da Vinci Code : Preview  17 May 2006
...in his cryptic message. Being a symbologist himself, Langdon is fairly well versed with religious history and arts. At first, he ... - Apun Ka Choice,

Yeager heads the list of good candidates  17 May 2006
She was elected to the Santa Clara council in 1994 and has been mayor since 2002. But she is not as well versed on countywide issues. ... - San Jose Mercury News,

Jeremy Warner's Outlook: For the Sage of Omaha, Tesco ticks all ...  17 May 2006
Agius. As a long-standing Lazard's man, Mr Agius is as well versed as any in the City's grand old tradition of fleecing the client. - Independent,

Electronic voting is secure, firm assures township residents  17 May 2006
...the Internet-based system being used in next fall's vote in Edwardsburgh-Cardinal Township without drawing a question from a council already well-versed in the ... - Brockville Recorder and Times,

Intuitive Coach Tony Uberoi to Appear at the FIRST STAR PSYCHIC ...  17 May 2006
Although palmistry remains his first love, Tony is very well versed in the psychic realms including Astrology, Numerology, Runes, Tarot Cards, as well as ... - TravelVideo.tv (press release)

Karate High School  17 May 2006
When thinking of someone who is well versed in video games, connections are usually made to sloths, to people who don’t leave the house all day. ... - Mammoth Press

Bush injured; should Saints be concerned?  17 May 2006
Payton said. Bush's impact on New Orleans already is more than minor. Well-versed Catholics know there really was a St. Reginald of ... - Edmonton Sun,

District B13  17 May 2006
As a special intervention unit officer and expert in martial arts, he is a master in the field of infiltration, and well versed in successfully completing his ... - Comingsoon.net

Kenya: Nairobi Embassy 'Unaware' of Ex-CIA Chief's Visit to ...  17 May 2006
However, sources well versed in Somalia affairs told The EastAfrican that the former CIA chief was indeed in the country, during which time strategies for ... - AllAfrica.com,

Firefighters learn the ropes of height rescue  17 May 2006
As emergency responders, the firefighters/paramedics were expected to perform the high-angle trench rescue, a skill most in the department were not versed in. ... - Hibbing Daily Tribune,

Mont Blanc Resources Announces New Appointments  17 May 2006
Mr. Claussner is well versed in the areas of drilling and completions operations, reserve appraisals and economic evaluations. He ... - CCNMatthews (press release),

Letters: June ballot issues, etc.  17 May 2006
Davis candidates," editorial, May 3: The Bee got it right when it said Yolo County Board of Supervisors candidate Brenda Cedarblade is well-versed on issues ... - Sacramento Bee,

DVD Review: Bush's Brain  17 May 2006
I am not exceptionally well versed in politics, but after a lifetime of hearing abuse, ignorance, and intolerance spewed from the mouths of folks who ... - Blogcritics.org,

Scorpions Add Director of Public Relations and Broadcasting  17 May 2006
...hockey. From basketball to football to volleyball to baseball - and even bicycle racing - he became well versed in many sports. ... - OurSports Central (press release),

Indianapolis Strikes Up The Band to Promote The City  17 May 2006
Band members also have been versed on Indianapolis and its attractions so they can inform as well as entertain audiences locally and regionally. ... - Inside INdiana Business (press release),

A friend in Dale, a friend indeed  17 May 2006
The two talked about USC’s surprising season, and Tharp says Earnhardt was well versed in the names of USC players, particularly that of running back Mike ... - Myrtle Beach Sun News,

Professor went from blue-collar worker to well-versed poet  May 15, 2006
By BETH LOECHLER. GRAND RAPIDS, Mich. (AP) — Poetry comforted David Cope through his parents' divorce and the deaths of friends ... - MLive.com,

Versed in the art of divot etiquette  May 15, 2006
A divot is the piece of sod that is displaced when the club strikes the ground and leaves a scraped depression in the soil below. ... - Auburn Journal,

Discovery Middle actors well-versed in Silverstein  May 10, 2006
By GREGG L. PARKER. Scenes are blocked, lines are memorized, and the first cue will be called Tuesday for the spring play at Discovery Middle School. ... - Huntsville Times,

A well-versed researcher turns to poetry  Apr 20, 2006
By SL Wykes. People already know Sharon Olson. Not likely by name, but by her presence at the reference desk in the Palo Alto main library. ... - San Jose Mercury News,

Grace is well versed in district’s delights  Apr 28, 2006
By LYNDSEY WRIGHT. A NEW holiday brochure is spreading the word about the array of attractions Tynedale has to offer. Tynedale Council ... - Hexham Courant,

Well-versed vote seeker Husband’s bulwark to break into a ...  Apr 21, 2006
Haldia/Mahishadal, April 21: Even the CPM in this port town is at times scared of her, because of, among other things, the poems she writes. ... - Calcutta Telegraph,

Versant deemed well-versed in psychological health  Apr 20, 2006
Versant Inc., a Milwaukee marketing firm, recently garnered a Psychologically Healthy Workplace Award from the American Psychological Association. ... - Milwaukee Journal Sentinel (subscription),

Versed in reality  Apr 27, 2006
A: It depends on what kinds of writing and teaching you're doing. Uh, you know, poetry, there is no money in it. I mean, I do about ... - MaineToday.com,

Hawaiians Deserve Recognition from Federal Government  May 15, 2006
We benefitted from the advice provided by tribal leaders who were willing to share lessons learned and from constitutional scholars well-versed in federal ... - Hawaii Reporter,

Achuthanandan’s to be Kerala chief minister  May 15, 2006
Unlike his predecessor Nayanar, Achuthanandan is uncomfortable with English but of late has been trying his best to be well versed in the language. ... - India eNews.com,

This menu uses javascript This menu uses javascript This menu uses ...  May 15, 2006
...interactive white boards. The younger pupils have always had the boards and are all well versed in how to use them. But the reception ... - South Tyneside Today,

Outside View: Finding a solution to the Iran crisis  May 15, 2006
...behind-the-scenes bilateral conspiracy. The leading Republicans are well versed in the technique. The same US Defense Secretary ... - World Peace Herald,

Tired Of Haggling, Couple Turns To Auctioning Home  May 15, 2006
..."You need to be well-versed in what you're doing with it, because you can get yourself into trouble," Realtor Scott Heise said. ... - WRAL.com,

State still needs more competent teachers  May 15, 2006
Though they might not be versed in pedagogy, the program's teachers often are more effective than their traditionally trained colleagues. ... - Honolulu Star-Bulletin,

Holiday Mathis' horoscopes for May 15  May 15, 2006
Become versed in other cultures, and you'll attract the kind of friends who improve your business and make your life more beautiful. ... - Chicago Sun-Times,

Elevator to the Gallows  May 15, 2006
May 15, 2006 - No matter how well-versed one might be (or at least profess to be) as a moviegoer or cinephile, there will always be more films to watch. ... - IGN,

Rabies Kills Texas Boy, 16  May 15, 2006
Once rabies was confirmed—based on antibodies in her cerebrospinal fluid and serum—physicians placed her in a coma, using ketamine and Versed (midolazam). ... - MedPage Today,

College lecturer protected against arrest  May 15, 2006
He teaches Economics and as such is well versed with money matters and the same would stand him in good stead for a case under section 295, 427 IPC recorded ... - Afternoon Dispatch & Courier,

Lawmakers' inactions help boost gas prices  May 15, 2006
As these companies merged they closed down refining and storage facilities. These companies are well- versed in the law of supply and demand. ... - Albany Times Union,


Other information


Indication
For use in pediatric patients for sedation, anxiolysis, and amnesia prior to diagnostic, therapeutic, or endoscopic procedures or before induction of anesthesia.

Pharmacology
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and hypnotic activities. Benzodiazepine pharmacologic effects appear to result from reversible interactions with the (gamma)-amino butyric acid (GABA) benzodiazepine receptor in the CNS, the major inhibitory neurotransmitter in the central nervous system. The action of midazolam is readily reversed by the benzodiazepine receptor antagonist, flumazenil.

Mechanism Of Action
It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the brain. Benzodiazepines increase the activity of GABA, thereby producing a calming effect, relaxing skeletal muscles, and inducing sleep. Benzodiazepines act as agonists at the benzodiazepine receptors, which form a component of the benzodiazepine-GABA receptor-chloride ionophore complex. Most anxiolytics appear to act through at least one component of this complex to enhance the inhibitory action of GABA.

Drug Category
Anesthetics, Intravenous; Anti-anxiety Agents; Hypnotics and Sedatives; Adjuvants, Anesthesia; GABA Modulators; ATC:N05CD08

Brand Names/Synonyms
CHEMBANK1834; Dea No. 2884; Dormicum; Midazolam; Midazolam Base; Midazolam Hcl; Midazolamum [Inn-Latin]; Versed

Dosage Forms
LIQUID; SOLUTION

Absorption
Rapidly absorbed after oral administration (absolute bioavailability of the midazolam syrup in pediatric patients is about 36%, and intramuscular is greater than 90%).

Interactions
Interactions for Midazolam:

Drug Interactions:    Inhibitors of CYP3A4 Isozymes: Caution is advised when midazolam is administered concomitantly with drugs that are known to inhibit the cytochrome P450 3A4 enzyme system (ie, some drugs in the drug classes of azole antimycotics, protease inhibitors, calcium channel antagonists, and macrolide antibiotics). Drugs such as erythromycin, diltiazem, verapamil, ketoconazole, fluconazole and itraconazole were shown to significantly increase the C max and AUC of orally administered midazolam. These drug interactions may result in increased and prolonged sedation due to a decrease in plasma clearance of midazolam. Although not studied, the potent cytochrome P450 3A4 inhibitors ritonavir and nelfinavir may cause intense and prolonged sedation and respiratory depression due to a decrease in plasma clearance of midazolam. Caution is advised when VERSED Syrup is used concomitantly with these drugs. Dose adjustments should be considered and possible prolongation and intensity of effect should be anticipated.

Inducers of CYP3A4 Isozymes:   Cytochrome P450 inducers, such as rifampin, carbamazepine, and phenytoin, induce metabolism and caused a markedly decreased C max and AUC of oral midazolam in adult studies. Although clinical studies have not been performed, phenobarbital is expected to have the same effect. Caution is advised when administering VERSED Syrup to patients receiving these medications and if necessary dose adjustments should be considered.

CNS Depressants:   One case was reported of inadequate sedation with chloral hydrate and later with oral midazolam due to a possible interaction with methylphenidate administered chronically in a 2-year-old boy with a history of William's syndrome. The difficulty in achieving adequate sedation may have been the result of decreased absorption of the sedatives due to both the gastrointestinal effects and stimulant effects of methylphenidate.

The sedative effect of VERSED Syrup is accentuated by any concomitantly administered medication which depresses the central nervous system, particularly narcotics (eg, morphine, meperidine and fentanyl), propofol, ketamine, nitrous oxide, secobarbital and droperidol. Consequently, the dose of VERSED Syrup should be adjusted according to the type and amount of concomitant medications administered and the desired clinical response.

No significant adverse interactions with common premedications (such as atropine, scopolamine, glycopyrrolate, diazepam, hydroxyzine, and other muscle relaxants) or local anesthetics have been observed.



Chemical IUPAC Name
Not Available

Chemical Formula
C18H13ClFN3

Half Life
2.2-6.8 hours

Drug Type
Approved Drug

# Accession No
APRD00680

CAS Registry Number
59467-70-8

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