Ventolin: profile and news






HealthFirst-Asthma treatment  May 4, 2006
..."When I was given a Ventolin inhaler after my late 20's, I became very dependent upon it. I would pick up my wallet, my car keys ... - ABC12.com,

Environmental Regulations to Force Current Formulations of Leading ...  Apr 24, 2006
...air treaty) will result in a reverse-generic-erosion phenomenon for all albuterol asthma inhalers in 2008, including GlaxoSmithKline's Ventolin and Schering ... - Yahoo! News (press release)

Asthma Control: Tips on How to Cure your Asthma Naturally  May 9, 2006
...frequently. This made for many sleepless nights (why with reaching for my ventolin inhaler) and boring days locked in doors. This ... - DailyIndia.com,

Asthma treatment: How I cured my asthma!  Apr 19, 2006
With Ventolin tablets and inhalers selling in such high numbers, a drug-free alternative would definitely prove to alter conditions in the asthma treatment ... - PR Leap (press release),

Handbook breathes life into asthma education  May 4, 2006
Leo J. Austin Secondary School. "I haven't had an attack for a long time, but I take Ventolin before I go on the track. It seems to work.". ... - Toronto Star,

$33,000 fine for selling medicines over internet  May 8, 2006
...and August 2003. Included in their list of goods were Ventolin inhalers, Xenical and Argentinian-sourced Proscar. Many medicines ... - New Zealand Herald,

Ammonia leak causes nausea  May 1, 2006
...on Sunday none of the children who complained of nausea, vomiting and dizziness were admitted to hospital but they were given an inhalant, ventolin, to help ... - Fort McMurray Today,

Medical bag stolen  Apr 24, 2006
...equipment, oxygen masks as well as a separate bag with various drugs including epinephrine, ASA, glucagon, nitrogyclerin spray, ventolin and assorted syringes. ... - Toronto Star,

Toronto EMS alerts public to missing paramedic equipment bag  Apr 24, 2006
...included in the equipment bag are a primary care symptom relief drug kit containing epinephrine, ASA, glucagon, nitroglycerin spray and ventolin along with ... - 680 News,

Writing off pain  Apr 28, 2006
...uterine bleeding, and was diagnosed with a suspected infection of the uterine membrane, during which time she had labour suppressed with Ventolin, was prepared ... - Courier Mail,

Asthma terror for my son . . and 5.2m others  Apr 24, 2006
A viral infection is the closest to a diagnosis we got, and now we have blue Ventolin inhalers at home just in case it happens again. ... - Scotsman,

WEB EXTRA: Labour board to rule on first responders  Apr 26, 2006
Fire Paramedic Service approved new firefighter-paramedic first responders to treat patients with drugs; nitro spray, nitro patches, ventolin ampules, ASA and ... - Winnipeg Free Press (subscription),

Dirt pills may help young asthmatics  Apr 26, 2006
She is now on treatments such as Ventolin, but she still suffers from asthma and had another attack in recent weeks that forced the family to take her to ... - NEWS.com.au,


Other information


Indication
For relief and prevention of bronchospasm due to asthma; Emphysema; Chronic bronchitis

Pharmacology
Albuterol, a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity.

Mechanism Of Action
Albuterol is a beta(2)-adrenergic agonist. It stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that Albuterol increases cAMP production by activating adenylate cyclase, and the actions of albuterol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentrations leads to a smooth muscle relaxation. Increased intracellular cyclic AMP concentrations also cause an inhibition of the release of mediators from mast cells in the airways.

Drug Category
Adrenergic beta-Agonists; Tocolytic Agents; Bronchodilator Agents; ATC:R03AC

Brand Names/Synonyms
AH 3365; Accuneb; Aerolin; Albuterol; Albuterol Sulfate; Albuterol Sulfate Hfa; Asmaven; Broncovaleas; Cetsim; Cobutolin; Ecovent; Loftan; Proventil; Proventil Inhaler; Proventil-Hfa; Rotahaler; Salbulin; Salbutamol; Salbutamol Free Base; Salbutamol Sulfate; Salbutamol Sulphate; Salbutard; Salbutine; Salbuvent; Solbutamol; Sultanol; Venetlin; Ventalin Inhaler; Ventolin; Ventolin Hfa; Ventolin Inhaler; Ventolin Rotacaps; Volma; Volmax; Xopenex; Xopenex Hfa

Dosage Forms
ORAL SOLUTION; SYRUP; TABLETS; EXTENDED-RELEASE TABLETS; INJECTION (Intramuscular, Intravenous)

Absorption
Systemic absorption is rapid following aerosol administration

Interactions
-->Interactions for Albuterol:

Other short-acting sympathomimetic aerosol bronchodilators should not be used concomitantly with albuterol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Albuterol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the vascular system may be potentiated.

Beta-Blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as VENTOLIN Inhalation Aerosol, but may produce severe bronchospasm in patients with asthma. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics: The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Digoxin: Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving albuterol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and albuterol.

 


 


Chemical IUPAC Name
2-(hydroxymethyl)-4-(1-hydroxy-2-tert-butylamino-ethyl)-phenol

Chemical Formula
C13H21NO3

Half Life
1.6 hours

Drug Type
Approved Drug

# Accession No
APRD00553

CAS Registry Number
18559-94-9


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