Thorazine: profile and news

Wanee Music Festival Live Oak, FL 4/14-15/2006 16 May 2006
...first shows of their тАЬStill RagingтА? tour) and delighted Mule fans with тАЬShe Said, She Said,тА? тАЬMule,тА? тАЬSoulshine,тА? тАЬThorazine ShuffleтА? and ... - Glide Magazine,

In high spirits: Red-carpet celebs dress for excess May 13, 2006
ScarfaceтА? E3 festivities. Animal print, tulle, little arm socks - add a veil, and itтАЩs my Cousin ThorazineтАЩs wedding dress. SHEтАЩS ... - Boston Herald,

Have you taken Zyprexa and developed diabetes?Information and news ... May 5, 2006
...top selling drug.It was approved by the FDA in 1996 ,an 'atypical' antipsychotic a newer class of drugs without the motor side effects of the older Thorazine. ... - MediaSyndicate (press release)

Seroquel big, and could get bigger Apr 23, 2006
An improvement on earlier drugs like Haldol and Thorazine, the atypical antipsychotics have their own set of possible side effects, including weight gain ... - The News Journal,

Ginsberg's poem inspires collective 'Howl' Apr 23, 2006
An overnight stay became a one-month in-patient treatment, and by the time we all met for Thanksgiving, the Thorazine had helped him put on 30 pounds. ... - The Grand Rapids Press,

Guilty plea in high-speed chase Apr 22, 2006
Standing next to defense attorney David Harding, Gopshes told the court that he was taking the antipsychotic drug Thorazine, that he was under the care of a ... - Baltimore Sun,

Other information

Indication
For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.

Pharmacology
Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Mechanism Of Action
Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).

Drug Category
Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines; ATC:N05AA01

Brand Names/Synonyms
Largactil; Contomin; Chlorpromados; Chlorderazin; Ampliactil; Aminazine; Aminazin; Fenactil; Fenaktyl; Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine; Thorazine Spansule

Dosage Forms
DROPS; LIQUID; SOLUTION; SYRUP; TABLET

Absorption
Not Available

Interactions
Interactions for Chlorpromazine: The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia. Interactions may also occur with the following: anti-depressants/anti-anxiety drugs, drugs used to treat an overactive thyroid, beta-blockers (e.g., propranolol), sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), any other drugs that may make you drowsy.

Chemical IUPAC Name
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine

Chemical Formula
C17H19ClN2S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00482

CAS Registry Number
50-53-3