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Terconazole: profile and news
Perrigo Company Reports Third Quarter Fiscal 2006 Financial ... Apr 27, 2006 Other information Indication Candidiasis (a yeast-like fungal infection) of the vulva and vagina Pharmacology Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although terconazole and other triazoles have 3 nitrogens in the azole ring. Mechanism Of Action Terconazole may exert its antifungal activity by disrupting normal fungal cell membrane permeability. Terconazole and other triazole antifungal agents inhibit cytochrome P450 14-alpha-demethylase in susceptible fungi, which leads to the accumulation of lanosterol and other methylated sterols and a decrease in ergosterol concentration. Drug Category Antifungals; Antifungals; ATC:G01AG02 Brand Names/Synonyms Fungistat; Gyno-Terazol; Terazol; Terazol 3; Terazol 7; Terconazole; Tercospor; Triaconazole Dosage Forms Vaginal cream and Vaginal suppositories Absorption Following intravaginal administration of terconazole in humans, absorption ranged from 5-8% in three hysterectomized subjects and 12-16% in two non-hysterectomized subjects with tubal ligations Interactions -->Interactions for Terconazole: TERAZOL 7 Vaginal Cream 0.4% and TERAZOL 3 Vaginal Suppositories 80 mg The therapeutic effect of these products is not affected by oral contraceptive usage. TERAZOL 3 Vaginal Cream 0.8% The levels of estradiol (E2) and progesterone did not differ significantly when 0.8% terconazole vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive. |
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