Tenex: profile and news

Why US should lift curbs on Russian uranium exports  Apr 28, 2006
According to Russia’s Techsnabexport (Tenex), one of the world’s largest producers and exporters of nuclear materials, services and equipment with the ... - Gulf Times,

Weston preparing for storm season  Apr 23, 2006
...private gas stations. Many of them did not have generators to run pumps. Commissioners awarded Tenex Enterprises Inc. of Coral Springs ... - Sun-Sentinel.com,

Breathing life into financing research  Apr 30, 2006
...gradually widening his circle of advisers and getting introductions to potential supporters such as angel investor Paul Quadros of Tenex Medical Investors. ... - San Francisco Chronicle,

Ped Med: ADHD Drug Remedies Hit and Miss  Apr 21, 2006
...antidepressants, such as the tricyclics Imipramine or Desipramine or bupropion (Wellbutrin), anti-hypertension medications like guanfacine (Tenex) or clonidine ... - National Ledger,

City buys generators, other hurricane gear  Apr 18, 2006
Construction is scheduled to start May 1 and be completed by June 15. The $286,000 contract was awarded to Tenex Enterprises, Inc., of Coral Springs. ... - Miami Herald,

The potential for increased sedation when guanfacine is given with other CNS-depressant drug should be appreciated. The administration of guanfacine concomitantly with known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration. In such cases, therefore, more frequent dosing may be required to achieve or maintain the desired hypotensive response. Further, if guanfacine is to be discontinued in such patients, careful tapering of the dosage may be necessary in order to avoid rebound phenomena.

TCAs decrease the hypotensive effect of guanfacine. Noncardioselective beta-blockers (nadolol,porpranolol,timolol) may exacerbate rebound hypertension when guanfacine is withdrawn. The beta-blocker should be withdrawn first. The gradual withdrawal of guafacine or a cardioselective beta-blocker could be substituted.

Anticoagulants

Ten patients who were stabilized on oral anticoagulants were given guanfacine, 1-2 mg/day, for 4 weeks. No changes were observed in the degree of anticoagulation. In several well-controlled studies, guanfacine was administered together with diuretics with no drug interactions reported. In the long-term safety studies, guanfacine was given concomitantly with many drugs without evidence of any interactions. The principal drugs given (number of patients in parentheses) were: cardiac glycosides (115), sedatives and hypnotics (103), coronary vasodilators (52), oral hypoglycemics (45), cough and cold preparations (45), NSAIDs (38), antihyperlipidemics (29), antigout drugs (24), oral contraceptives (18), bronchodilators (13), insulin (10), and beta blockers (10).

Laboratory Test

In clinical trials, no clinically relevant laboratory test abnormalities were identified as causally related to drug during short-term treatment with guanfacine.

Drug/Laboratory Test Interactions

No laboratory test abnormalities related to the use of guanfacine have been identified.