Temazepam: profile and news

Arrests For Prescription Drug Crimes Increase May 15, 2006
James Michael Lea last weekend and found about 30 prescription pills including Oxycontin, Xanax, Phenobarbital, Ambien, Lunesta, Temazepam, Clonazepam, Vicodin ... - cbs4denver.com,

CU student accused of peddling prescription drugs May 9, 2006
...bag. The pills included Oxycotntin, Xanax, Phenobarbital, Ambien, Lunesta, Temazepam, Clonazepam, Vicodin, and Percocet. Police ... - 9NEWS.com,

Man found with drugs, weapons May 1, 2006
A man was allegedly found with 2.5 ounces of crack cocaine, seven ecstasy pills, one gram of marijuana, nine Temazepam tablets, a digital scale and cash. ... - Winnipeg Sun,

Q&A: euthanasia May 12, 2006
...of the Voluntary Euthanasia Society, was judged to have "abused his position as a doctor" by writing a prescription in his own name for temazepam, which he ... - Guardian Unlimited,

Mother arrested in plot to sell drugs May 12, 2006
Documents filed in Hamilton Circuit Court identified various drugs seized from the home of Dianne Hauss, including Ambien, Sonata and temazepam (for insomnia ... - Indianapolis Star,

CU Police Make Prescription Drug Bust May 9, 2006
...the investigators found more than 80 items, including about 30 pills including Oxycontin, Xanax, Phenobarbital, Ambien, Lunesta, Temazepam, Clonazepam, Vicodin ... - TheDenverChannel.com,

Nurse fights pill-in-sandwich case Apr 24, 2006
Under cross-examination by defence lawyer Mary Anne Hartley, nurse Thomas Cayad said he did nothing to stop Ms Todoroff from putting two Temazepam tablets into ... - Melbourne Herald Sun,

Mother and son face drug dealing charges May 12, 2006
Officers found pills located in kitchen cabinets, in the stove, a south bedroom closet and a cabinet drawer in the master bedroom which also included Temazepam ... - Noblesville Daily Times,

It was bad place to pass out May 2, 2006
They called in the cops, who found him with 2.5 ounces of crack, seven ecstasy pills, a gram of marijuana, nine Temazepam tablets, a digital scale, cash, a ... - Winnipeg Sun,

Counting sheep May 3, 2006
The 59-year-old from Redcar, Cleveland, was prescribed temazepam for stress-induced insomnia 20 years ago, but it wasn't until he changed GPs two years ago ... - Saga Health News,

Home and away Apr 22, 2006
...'But she's told me she wants to be found. "I'll wait until you get me," she tells me.' When she comes back she'll be drunk on vodka or stoned on temazepam. ... - The Observer,

Stoned at school Apr 29, 2006
...“We’re talking about street-bought ‘benzos’, like valium and temazepam, and ecstacy, amphetamines and solvents as well. ... - Sunday Herald,

YES, I WAS AT THORNE EXECUTION BUT I DID NOT FIRE THE FATAL SHOT Apr 27, 2006
...he told McFadyen he should just take the drugs, which included a kilo of amphetamine sulphate (speed) and the powerful prescription drugs temazepam and temgesic ... - Glasgow Daily Record,

New weapons in travelers' round-the-clock jet-lag fight Apr 21, 2006
That may be because the drugs stay in the body for briefer periods than the older pills such as Dalmane (flurazepam) and Restoril (temazepam), among others ... - Los Angeles Times,

Other information

Indication
For the short-term treatment of insomnia (generally 7-10 days).

Pharmacology
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.

Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Drug Category
Anti-anxiety Agents; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05CD07

Brand Names/Synonyms
Apo-Temazepam; Cerepax; Crisonar; ER 115; Euhypnos; Euipnos; Gelthix; Hydroxydiazepam; K-3917; Levanxene; Levanxol; Levanzene; Mabertin; Methyloxazepam; N-Methyloxazepam; Normison; Novo-Temazepam; Oxydiazepam; Perdorm; Planum; Remestan; Restoril; Signopam; Temaz; Temazepam; WY 2917; Wy-3917

Dosage Forms
CAPSULE (7.5 mg, 15 mg, and 30 mg)

Absorption
Well absorbed, minimal first-pass metabolism.

Interactions
Interactions for Temazepam:

The pharmacokinetic profile of temazepam does not appear to be altered by orally administered cimetidine dosed according to labeling.

Chemical IUPAC Name
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one

Chemical Formula
C16H13ClN2O2

Half Life
10-20 hours

Drug Type
Approved Drug

# Accession No
APRD00676

CAS Registry Number
846-50-4