Strattera: profile and news
Are You Sure You're Feeling OK? May 16, 2006
...bewildering territory. One of PALP's 2006 Bitter Pill Awards went to Lilly for a TV commercial plugging its drug Strattera. In the ... - AlterNet,
Ped Med: ADHD Drug Remedies Hit and Miss Apr 21, 2006
In 2003, amidst great hoopla, another option became available in a market stimulants had monopolized for decades: Eli Lilly and Co.'s Strattera, touted as the ... - National Ledger,
Seeking the Tao of Eli Lilly Apr 17, 2006
The worrying has been going on for some time, especially about Zyprexa for schizophrenia, Strattera for attention-deficit hyperactivity disorder and, more ... - TheStreet.com
Lilly reports higher first-quarter earnings Apr 20, 2006
Sales of Strattera, for attention deficit disorder, showed renewed strength, up 27% to $152 million. Strattera sales had been under ... - MarketWatch
Finding a focus Apr 17, 2006
...hyperactivity disorder. There was Adderall XR (extreme fatigue) and Concerta (aggression) and Strattera (hallucinations). Each time ... - Pioneer Press,
Deceptive Prescription Drug Marketing Is Widespread And Dangerous May 3, 2006
...practices. Among this year’s award winners was Eli Lilly, for its distracting TV ad for an attention deficit disorder drug (Strattera). ... - MASSPIRG,
Lilly Reports Q1 EPS of $.77, or 13% Growth Apr 20, 2006
Newer products -- Alimta(R), Byetta(R), Cialis(R), Cymbalta, Forteo(R), Strattera(R), Symbyax(R), Xigris(R) and Yentreve(R) -- collectively grew 59 percent ... - MSN Money
Pediatric panel says black box warning not necessary for ADHD ... Apr 28, 2006
...that a medication guide for patients be created to describe potential risks of all ADHD medications, including atomoxetine (Strattera), modafinil (Sparlon ... - AAP News (subscription)
Advisers reject strongest ADHD warnings Apr 18, 2006
Adding black-box warnings to some or all the drugs, which also include Adderall and Strattera, could cause more harm than good, some experts told the panel ... - kgw.com (subscription),
Dubious awards: For Lilly, a 'Bitter Pill' Apr 27, 2006
...maker won a Bitter Pill Award this week from the consumer activist group Community Catalyst for its "overzealous and questionable" TV ads for Strattera, a drug ... - Indianapolis Star,
Pharma ads should have us all losing sleep May 5, 2006
...including sleeping medications Ambien, time-release Ambien CR and Lunesta; statins known as Lipitor and Crestor; and the attention-deficit medication Strattera ... - Fort Wayne News Sentinel,
Cephalon Q1 Profit Drops 86%, Boosts 2006 Sales And Earnings ... May 2, 2006
...million. Strattera, for attention-deficit hyperactivity disorder, generated sales of $152.2 million, a 27% increase. GlaxoSmithKline ... - Trading Markets,
Former Lilly exec to head CoLucid May 5, 2006
White managed a team of 300 and helped steer development of neuroscience drugs like the attention deficit hyperactivity disorder medication Strattera and the ... - Indianapolis Business Journal,
Health Notes May 8, 2006
Other well-known drugs cited this year included the sleep med Lunesta; statins Lipitor and Crestor; and the attention-deficit drug Strattera. ... - Savannah Morning News,
A big dose of criticism May 4, 2006
A spokeswoman for Eli Lilly, maker of the adult attention-deficit disorder drug Strattera, defended the television advertisement that garnered it a Bitter Pill ... - NorthJersey.com,
Beth Israel builds all-in-one cardiac operating room May 1, 2006
...medications, known as statins, Lipitor and Crestor, respectively; and Eli Lilly for a commercial fashioned after a video game to sell Strattera, a drug for ... - Boston Globe,
Lilly Posts Q1 Profit Apr 20, 2006
Newer products -- Alimta®, Byetta®, Cialis®, Cymbalta, Forteo®, Strattera®, Symbyax®, Xigris® and Yentreve® -- collectively grew 59 percent, to ... - Inside INdiana Business (press release),
Lilly`s Evista beats tamoxifen Apr 17, 2006
Moskowitz noted that Zyprexa, Strattera and Cymbalta are struggling and Lilly`s injectable insulin franchise could be challenged by Sanofi-Aventis` Apidra. ... - Monsters and Critics.com,
UPDATE 1-Lilly quarterly profit rises, boosted by new drugs Apr 20, 2006
...million. Strattera, for attention-deficit hyperactivity disorder, generated sales of $152.2 million, a 27 percent increase. But ... - Reuters
Consumer group awards 'bitter pills' to drugmakers Apr 27, 2006
The list also includes Pfizer Inc.'s cholesterol-lowering treatment Lipitor; Sanofi-Aventis' sleep drug Ambien; Eli Lilly and Co.'s Strattera for attention ... - Reuters.uk,
Lilly: Like the Flower, Not the Stock Apr 20, 2006
Lilly's top drugs performed. Zyprexa and Evista were weak, and Cymbalta, Strattera, Alimta, and Foreto were quite strong. I was a ... - Motley Fool
Healthwrap: Healthy kids grow the same way Apr 27, 2006
...made by Sepracor Inc.; Lipitor, Pfizer Inc.'s treatment designed to lower cholesterol; Ambien, a sleeping tablet made by Sanofi-Aventis; Strattera, an ADHD ... - United Press International
Health Highlights: April 26, 2006 Apr 26, 2006
The Driven to Distraction Award: For Hawking an Attention Deficit Drug by Distracting Consumers with ADHD -- presented to Strattera (Eli Lilly). ... - Food Consumer,
Proper diagnosis of adult ADHD can help adults compensate ... Apr 30, 2006
..."Once you realize you have it, that's half the ball game," she said. She tried the prescription medications Strattera and Adderall. ... - commercialappeal.com (subscription),
Liver Success Apr 17, 2006
...it governs is involved in metabolizing about 70 different drugs, including the antidepressants Paxil and Prozac and the ADHD drug Strattera, explains Mrazek. ... - Washington Post,
US Adults Lack Knowledge but Have Concerns About Common Treatments ... Apr 27, 2006
...and Strattera, which are used to treat people with attention deficit hyperactivity disorder (ADHD). Overall, how effective do you think these drugs. ... - Yahoo! News (press release)
PAL Names Bitter Pill Award Winners Apr 27, 2006
...and the remaining three awards were shared among makers of five of the nation"s most well-known drugs: Lunesta, Ambien/AmbienCR, Lipitor, Crestor and Strattera ... - PharmaLive.com (press release),
US Adults Lack Knowledge but Have Concerns About Common Treatments ... Apr 27, 2006
TABLE 1 PERCEIVED EFFICACY OF ADHD DRUGS "There are a number of prescription drugs, such as Adderall, Concerta, Ritalin and Strattera, which are used to treat ... - PR Newswire (press release),
Other information
Indication
For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD).
Pharmacology
Atomoxetine is an amphetamine used to treat ADD/ADHD in children and adults. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. It increases motor activity and mental alertness, and reduces drowsiness and a sense of fatigue, decreasing motor restlessness and improves one's ability to focus. Peripheral actions include elevation of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. There is neither specific evidence which clearly establishes the mechanism whereby amphetamine produces mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system. Atomoxetine activates the brain stem arousal system and cortex to produce its stimulant effect.
Mechanism Of Action
Amphetamines release stores of norepinephrine and dopamine from nerve endings by converting the respective molecular transporters into open channels. Amphetamines also releases stores of serotonin from synaptic vesicles. Like methylphenidate (Ritalin) amphetamines also prevent the monoamine transporters for dopamine and norepinephrine from recycling them (called reuptake inhibition) which leads to increased amounts of dopamine and norepinephrine in synaptic clefts. These combined effects rapidly increases the concentrations of the respective neurotransmitters in the synaptic cleft, which promotes nerve impulse transmission in neurons that have those receptors.
Drug Category
Antidepressants; Central Nervous System Agents; ATC:N06BA09
Brand Names/Synonyms
Atomoxetine; Strattera; Tomoxetina [Spanish]; Tomoxetine; Tomoxetine [Inn]; Tomoxetinum [Latin]
Dosage Forms
CAPSULE
Absorption
Not Available
Interactions
-->Interactions for Atomoxetine:
Drug-Drug Interactions
Albuterol ¾ STRATTERA should be administered with caution to patients
being treated with systemically-administered (oral or intravenous) albuterol (or other beta2 agonists)
because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate
and blood pressure.
CYP2D6 inhibitors ¾ Atomoxetine is primarily metabolized by the CYP2D6
pathway to 4-hydroxyatomoxetine. In EMs, selective inhibitors of CYP2D6 increase atomoxetine steady-state plasma
concentrations to exposures similar to those observed in PMs. Dosage adjustment of STRATTERA may be necessary when
coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine (see DOSAGE AND ADMINISTRATION). In EM individuals treated with paroxetine or fluoxetine, the
AUC of atomoxetine is approximately 6- to 8-fold and Css,max is about 3- to 4-fold greater than
atomoxetine alone.
In vitro studies suggest that coadministration of cytochrome P450 inhibitors to PMs will not increase the plasma
concentrations of atomoxetine.
Monoamine oxidase inhibitors ¾ See CONTRAINDICATIONS.
Pressor agents ¾ Because of possible effects on blood pressure, STRATTERA
should be used cautiously with pressor agents.
Chemical IUPAC Name
N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine
Chemical Formula
C17H21NO
Half Life
5 hours
Drug Type
Approved Drug
# Accession No
APRD00614
CAS Registry Number
82248-59-7
