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Other information Indication For the management of primary nocturnal enuresis and indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary Pharmacology Desmopressin is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Desmopressin is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region and is also indicated for the management of primary nocturnal enuresis. Mechanism Of Action Desmopressin emulates the actions of the natural pituitary hormone 8-arginine vasopressin (ADH). Drug Category Renal Agents; Hemostatics (20:12.16); Pituitary (68:28.00); ATC:H01BA02 Brand Names/Synonyms DESMOPRESSIN; Desmopresina [INN-Spanish]; Desmopressine [INN-French]; Desmopressinum [INN-Latin]; 1-Deamino-8-D-arginine vasopressin; 1-Desamino-8-D-arginine vasopressin; 1-Desamino-8-d-arginine-vasopressin; Desamino-8-D-arginine vasopressin, l-; Concentraid; DDAVP; Stimate Dosage Forms TABLET Absorption Not Available Interactions Interactions for Desmopressin: Although the pressor activity of Desmopressin is very low compared to its antidiuretic activity, large doses of Desmopressin Tablets should be used with other pressor agents only with careful patient monitoring. Chemical IUPAC Name 1-[[13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-4-yl]carbonyl]-N-[1-(carbamoylmethylcarbamoyl)-4-guanidino-butyl]-pyrrolidine-2-carboxamide Chemical Formula C46H64N14O12S2 Half Life 1.5-2.5 hours Drug Type Approved Drug # Accession No BIOD00112 CAS Registry Number 16679-58-6 |
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