Stelazine: profile and news

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Other information

Indication
For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation

Pharmacology
Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

Mechanism Of Action
Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Drug Category
Antipsychotics; Antiemetics; Phenothiazines; ATC:N05AB06

Brand Names/Synonyms
Apo-Trifluoperazine; Eskazine; Eskazinyl; Fluoperazine; Jatroneural; Modalina; Novo-Trifluzine; Pms Trifluoperazine; RP 7623; SKF 5019; Stelazine; Stelazine Concentrate; Stellazine; Synklor; Terfluzine; Trazine; Trifluoperazin; Trifluoperazina; Trifluoperazine; Trifluoperazine Dihydrochloride; Trifluoperazine Hcl; Trifluoperazine Hydrochloride; Trifluoromethylperazine; Trifluoroperazine; Trifluoroperazine Dihydrochloride; Trifluoroperazine Hydrochloride; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; Triphthazine; Triphthazine Dihydrochloride; Tryptazine; Tryptazine Dihydrochloride

Dosage Forms
SYRUP

Absorption
Not Available

Interactions
-->Interactions for Trifluoperazine:
No information provided.

Chemical IUPAC Name
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine

Chemical Formula
C21H24F3N3S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00173

CAS Registry Number
117-89-5