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Stavudine: profile and news
Treatment simplification appears clinically safe in children with ... May 11, 2006 HIV Pharmacology Workshop: The dangers of breaking up tablets for ... Apr 30, 2006 South Africa: Indian First-Line ARV Registered Apr 27, 2006 Zimbabwe: Fake ARVs on sale Apr 23, 2006 Enaleni unveils 3-in-1 Aids drug Apr 24, 2006 Anti-Aids drug registered in SA Apr 24, 2006 First-Line Antiretroviral Drug Triomune Registered in South Africa Apr 25, 2006 HIV Pharmacology Workshop: Are drug levels affected by racial ... Apr 30, 2006 Other information Indication For the treatment of human immunovirus (HIV) infections Pharmacology Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Mechanism Of Action Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Drug Category Anti-HIV Agents; Antimetabolites; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF04 Brand Names/Synonyms D4T; D4T & GM-CSF; DHT; DRG-0043; Ddethd; Ddetyd; Estavudina [Inn-Spanish]; STAVUDINE; STV; Sanilvudine; Stavudine; Stavudine [Usan:Ban:Inn]; Stavudinum [Inn-Latin]; Zerit; Zerit Xr; Zerut Xr Dosage Forms CAPSULE Absorption Following oral administration, stavudine is rapidly absorbed (bioavailability is 68-104%) Interactions -->Interactions for Stavudine: : Zidovudine competitively inhibits the intracellular phosphorylation of stavudine. Therefore, use of zidovudine in combination with ZERIT should be avoided. In vitro data indicate that the phosphorylation of stavudine is also inhibited at relevant concentrations by doxorubicin and ribavirin. The clinical significance of these in vitro interactions is unknown; therefore, concomitant use of stavudine with either of these drugs should be undertaken with caution. |
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