Sotradecol: profile and news

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Other information

Indication
For the treatment of of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves

Pharmacology
Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation .Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Mechanism Of Action
Sodium Tetradecyl Sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted Sodium Tetradecyl Sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.

Drug Category
Surface-Active Agents; Sclerosing Agents; ATC:C05BB04

Brand Names/Synonyms
CHEMBANK4537; Monotetradecylsulfate Sodium Salt; Myristyl Sulfate, Sodium Salt; Niaproof-4; S.T.D.; Sodium Myristyl Sulfate; Sodium Tetradecyl Sulfate; Sodium Tetradecyl Sulfate 99%; Sotradecol; TETRADECYL SULFATE; Tergitol-4; Tetradecyl Hydrogen Sulphate; Tetradecyl Sodium Sulfate; Tetradecyl Sulfate, Sodium Salt; Tetradecyl Sulfuric Acid; Texapon K 14

Dosage Forms
IV Solution

Absorption
Not Available

Interactions
Interactions for Sodium Tetradecyl Sulfate: No well-controlled studies have been performed on patients taking antiovulatory agents. The physician must use judgment and evaluate any patient taking antiovulatory drugs prior to initiating treatment with Sotradecol. Heparin should not be included in the same syringe as Sodium Tetradecyl Sulfate, since the two are incompatible.

Chemical IUPAC Name
1-sulfooxytetradecane

Chemical Formula
C14H30O4S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00575

CAS Registry Number
1191-50-0