Sonata: profile and news

Perlman is a delight at Pabst  16 May 2006
Mozart's Sonata K. 454 was gorgeous, and it was more than that. ... Perlman and De Silva took specifically French plasir in Faure's shimmering Sonata Opus 13. ... - Milwaukee Journal Sentinel (subscription),

Cooper ramps up the amperage, makes it work  16 May 2006
Cooper, in other words, doesn't fool around. She takes the audience's needs into account, and in Haydn's C-Major Sonata, Hob. XVI ... - San Francisco Chronicle,

Emory Chamber Music Society of Atlanta’s 2006-2007 Season ...  16 May 2006
Bach’s “Cello Suite no. 1 in G Major� and “Violin Sonata no. ... 2.�. Bach’s “Cello Suite no. 3 in C Major� and “Violin Sonata no. ... - Duluth Weekly,

Taliban escapees caught in Bulgaria, Central Asia  16 May 2006
...that Aceng Kurnia, 33, was guilty of "illegally owning firearms and explosives" for terrorism purposes by handing them over to Purnama Putra and Abdullah Sonata ... - Turkish Daily News (subscription),

Hinton Center grant to train apprentice carpenters  16 May 2006
...the Sun. MUSICAL STRUCTURE: SONATA FORM led by Dr. Keith DeFoor - Tuesday, June 20 (1 session), 1 - 3 pm, cost $5. UNCOVERING THE ... - Smoky Mountain Sentinel,

Deborah Voigt and Renée Fleming vs. the Ghosts of Met Divas Past  16 May 2006
Young pianists can stretch their techniques by working on a formidable Prokofiev sonata, but an aspiring lyric soprano could actually damage her voice by ... - New York Times,

Auction of blocks with building entitlements  16 May 2006
...plantings are Brooks, Tulare, Merchant, Celeste, Samba, Simone, Lapins, Chelin and Ulster, plus newer varieties still under trial: Santina, Tieton and Sonata. ... - Cowra Guardian,

Dozier: And a happy birthday to ...  16 May 2006
...will perform music from the film "Catch Me If You Can," and senior trumpeter Rachel Linsmeier will perform the first movement of the "Sonata for Trumpet" by ... - Lansing State Journal,

First Korean celebrity with Madame Tussauds wax statue  16 May 2006
Bae made his name with the TV drama "Winter Sonata.'' Bae's wax figure in Hong Kong is set against a snowy backdrop inspired by the show. ... - Malaysia Star,

AutoPacific Announces 2006 Vehicle Satisfaction Awards  16 May 2006
Premium Mid-Size sedan. Passat handily beat segment volume leaders Honda Accord, Toyota Camry and Hyundai Sonata. Passat wins by ... - Yahoo! News (press release)

Maxim Vengerov, Barbican Hall, London  May 15, 2006
At 36, he has put on a little weight, and perhaps his main work – Prokofiev’s spikey F minor Sonata, op.80 – was not altogether audience-friendly; still ... - Financial Times,

Hyundai Sonata  May 1, 2006
This is an great car in excellent condition. It has had all of its preventative maintainence done. It is still under Hyundai's great ... - Seattle Times,

Titan eyes youth via Sonata  May 3, 2006
Titan is planning to target youth through its popular brand Sonata. The company will use various communication platforms to reach out to the target audience. ... - Business Standard,

Sonata, India’s largest watch brand signs Mahendra Singh Dhoni ...  Apr 26, 2006
Sonata, the largest selling watch brand in the country has signed up world number one ODI batsman and youth icon Mahendra Singh Dhoni as its brand ambassador. ... - Moneycontrol.com,

Dhoni to endorse Sonata watches  Apr 26, 2006
Mumbai: Sonata, the largest selling watch brand from the Tata group has signed Indian batsman Mahendra Singh Dhoni as its brand ambassador. ... - CNN-IBN,

Dhoni to endorse Sonata watches  Apr 25, 2006
Mumbai: Sonata has signed up Mahendra Singh Dhoni as its brand ambassador. The cricketer will be endorsing the Sonata range of watches for the next two years. ... - Sify,

Hyundai Sonata  Apr 17, 2006
Mirrors. 2004 Sonata - wht, V6,CD,sunroof, Exc cnd. Warnty, 28k/mi $13950 360-447-0799. This is an great car in excellent condition. ... - Seattle Times,

Sonata Soft, Subros, VIP Inds & Visakha Inds Q4 Results  Apr 25, 2006
Sonata Software has reported 71 per cent rise in net profit on a consolidated basis to Rs 7.7 crore for the fourth quarter ended March 2006 compared with Rs ... - Business Standard,

Sonata Software Q4 net loss at Rs 8.4cr  Apr 25, 2006
Sonata Software has announced its fourth quarter results. The company has posted a net loss of Rs 8.4 crore (Rs 84 million) in its ... - Moneycontrol.com,

Sonata signs up Dhoni as brand amabassador  Apr 25, 2006
Mumbai, Apr 25: Sonata, largest selling watch brand of the Tatas, has signed up Indian batsman Mahendra Singh Dhoni as its brand ambassador. ... - NewKerala.com,

India : Dhoni to arm his wrist with Sonata  Apr 26, 2006
Mahendra Singh Dhoni, dashing wicketkeeper of Indian cricket has just been signed on by Sonata watches to endorse its brand for next two years. ... - Fibre2fashion.com,

Sobre Ruedas Magazine Names Hyundai Sonata 'Best Sedan 2005 Award ...  Apr 29, 2006
8 /PRNewswire/ -- Sobre Ruedas magazine named the Hyundai Sonata "Best 2005 Award Winner" in the Sedan category ahead of rivals like the Toyota Camry, Honda ... - HispanicBusiness.com,

Hyundai Sonata Tunefully Raises The Tone  Apr 26, 2006
First impressions last, and what clearly sticks out as the lasting impression of the new Hyundai Sonata is the rear end. Indefinitely ... - iAfrica.com,

Sonata Final dividend 60%. Total Dividend at 100%, maintains at 54 ...  Apr 26, 2006
The Board of Directors, at its meeting held here today, took on record the Audited Accounts of Sonata Software Ltd for the Quarter & year ended 31 st March ... - Moneycontrol.com,

Violinist catches fire at festival  May 16, 2006
The first half of the program had Beethoven's Violin Sonata No.7 in a curiously understated reading that did not always achieve the drama inherent in the music ... - Sun-Sentinel.com,

Concert Review: Camerata ends season with exuberance  May 15, 2006
Strictly speaking, only Franz Liszt's "Valse oubliée" for piano and Johannes Brahms' Sonata in E-flat for viola and piano represented the time frame that is ... - San Antonio Express (subscription),

Indonesian man jailed for plotting act of terrorism  May 15, 2006
The court found Aceng Kurnia, 33, guilty of handing over weapons and explosives to two men - Purnama Putra and Abdullah Sonata - in Ambon in the Malukus, in ... - ABC Asia Pacific,

Sonata packs more grunt with less thirst  Apr 20, 2006
Hyundai’s Sonata 3.3 V6 Elite is now more powerful yet more economical than the Holden Commodore V6. The Hyundai Sonata is now ... - Scoop.co.nz (press release),

A Most Unusual Mozart Collaboration  May 14, 2006
...rather crabbed experimentation. The opening Fantasia in C minor, K. 475, was grafted onto the Sonata in C minor, K. 457. This is ... - New York Sun,

Pianist Fliter makes spectacular debut with Chopin  May 16, 2006
Surprisingly, the evening got off to a shaky start with the pianist making three bad digital slips in the opening minutes of Haydn's Sonata in E minor, Hob. ... - Sun-Sentinel.com,

Listings: This week, don't miss...  May 13, 2006
CONCERTS Grigory Sokolov The Russian pianist’s recital comprises Bach’s French Suite No 3 in B minor, Beethoven’s Sonata in D minor, Op 31, No 2, and ... - The Sunday Times,

Church members have busy week  May 15, 2006
Practice, practice: Tim Denton (above), director of music/organ at Bethel Lutheran Church, runs through Mendelssohn Sonata No. 2 on the Wicks pipe organ. ... - Indianapolis Star,

Chopin and Liszt meet their match in Pollini  May 15, 2006
The pianist prefaced a sober, impeccably controlled account of Liszt's Sonata in B Minor with four of the composer's wonderfully strange, late pieces, music ... - Chicago Tribune,

ASO plays to full house on Mother's Day  May 15, 2006
Some of the works, like Debussy's “Clair de Lune,� Beethoven's “Moonlight� Sonata, or the Rachmaninoff Prelude in C sharp Minor, are the types of ... - Adrian Daily Telegram,

Mahendra Singh Dhoni to endorse Sonata  Apr 25, 2006
MUMBAI: Sonata, the watch brand has signed up world number one ODI batsman and youth icon Mahendra Singh Dhoni as its brand ambassador. ... - Indiantelevision.com,

Music : Heber Springs keys up for chamber music festival  May 12, 2006
2 in C major, op.87, by Johannes Brahms; and the first movement of the Piano Sonata No. 14 in c-sharp minor, op.27 No. ... 2 and Ballade (Sonata No. ... - Arkansas Democrat-Gazette (subscription),

Mahendra Singh Dhoni to bat for Sonata  Apr 25, 2006
After stamping his authority as the world's top batsman, Indian cricket's new star Mahendra Singh Dhoni will bat for Sonata, which has signed Dhoni as its ... - Televisionpoint.com,

Mitsuko Uchida Performs Mozart  May 12, 2006
The C minor Fantasy (K.475) and the C minor Sonata were played as a single piece, as they often are, followed by the rambling, ruminative B minor Adagio. ... - New York Times,

Imogen Cooper at Zankel Hall: Virtuosity Without Razzle-Dazzle  May 10, 2006
...nature. She began with Haydn's Sonata in C (Hob. ... keys. On its surface the sonata might not seem a proving ground for virtuosos. ... - New York Times,

Entourage is big, noisy  May 15, 2006
That's why the Sonata has been transformed into the most reliable car in North America. And why Hyundai is now entering the minivan market in a big way. ... - Montreal Gazette (subscription),

Music: On the crest of a wave  May 13, 2006
...any order) also harks back to Varèse, and behind him Debussy, the work does not take discontinuity to the parodic limit marked by Tippett’s Piano Sonata No 2 ... - The Sunday Times,

'Emerging Avant-Pop': From Charles Ives to Frank Zappa  May 10, 2006
...at the Sunday evening performance by the violinist Mary Rowell and the pianist Geoffrey Burleson it included Charles Ives's "Three-Page Sonata" (1905) and ... - New York Times,

As with all drugs, the potential exists for interaction with other drugs by a variety of mechanisms.

CNS-Active Drugs

Ethanol: Sonata 10 mg potentiated the CNS-impairing effects of ethanol 0.75 g/kg on balance testing and reaction time for 1 hour after ethanol administration and on the digit symbol substitution test (DSST), symbol copying test, and the variability component of the divided attention test for 2.5 hours after ethanol administration. The potentiation resulted from a CNS pharmacodynamic interaction; zaleplon did not affect the pharmacokinetics of ethanol.

Imipramine: Coadministration of single doses of Sonata 20 mg and imipramine 75 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration. The interaction was pharmacodynamic with no alteration of the pharmacokinetics of either drug.

Paroxetine: Coadministration of a single dose of Sonata 20 mg and paroxetine 20 mg daily for 7 days did not produce any interaction on psychomotor performance. Additionally, paroxetine did not alter the pharmacokinetics of Sonata, reflecting the absence of a role of CYP2D6 in zaleplonís metabolism.

Thioridazine: Coadministration of single doses of Sonata 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration. The interaction was pharmacodynamic with no alteration of the pharmacokinetics of either drug.

Venlafaxine: Coadministration of a single dose of zaleplon 10 mg and multiple doses of venlafaxine ER (extended release) 150 mg did not result in any significant changes in the pharmacokinetics of either zaleplon or venlafaxine. In addition, there was no pharmacodynamic interaction as a result of coadministration of zaleplon and venlafaxine ER.

Promethazine: Coadministration of a single dose of zaleplon and promethazine (10 and 25 mg, respectively) resulted in a 15% decrease in maximal plasma concentrations of zaleplon, but no change in the area under the plasma concentration-time curve. However, the pharmacodynamics of coadministration of zaleplon and promethazine have not been evaluated. Caution should be exercised when these 2 agents are coadministered.

Drugs That Induce CYP3A4

Rifampin: CYP3A4 is ordinarily a minor metabolizing enzyme of zaleplon. Multiple-dose administration of the potent CYP3A4 inducer rifampin (600 mg every 24 hours, q24h, for 14 days), however, reduced zaleplon C_max and AUC by approximately 80%. The coadministration of a potent CYP3A4 enzyme inducer, although not posing a safety concern, thus could lead to ineffectiveness of zaleplon. An alternative non-CYP3A4 substrate hypnotic agent may be considered in patients taking CYP3A4 inducers such as rifampin, phenytoin, carbamazepine, and phenobarbital.

Drugs That Inhibit CYP3A4

CYP3A4 is a minor metabolic pathway for the elimination of zaleplon because the sum of desethylzaleplon (formed via CYP3A4 in vitro) and its metabolites, 5-oxo-desethylzaleplon and 5-oxo-desethylzaleplon glucuronide, account for only 9% of the urinary recovery of a zaleplon dose. Coadministration of single, oral doses of zaleplon with erythromycin (10 mg and 800 mg, respectively), a strong, selective CYP3A4 inhibitor produced a 34% increase in zaleplon's maximal plasma concentrations and a 20% increase in the area under the plasma concentration-time curve. The magnitude of interaction with multiple doses of erythromycin is unknown. Other strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon. A routine dosage adjustment of zaleplon is not considered necessary.

Drugs That Inhibit Aldehyde Oxidase

The aldehyde oxidase enzyme system is less well studied than the cytochrome P450 enzyme system.

Diphenhydramine: Diphenhydramine is reported to be a weak inhibitor of aldehyde oxidase in rat liver, but its inhibitory effects in human liver are not known. There is no pharmacokinetic interaction between zaleplon and diphenhydramine following the administration of a single dose (10 mg and 50 mg, respectively) of each drug. However, because both of these compounds have CNS effects, an additive pharmacodynamic effect is possible.

Drugs That Inhibit Both Aldehyde Oxidase and CYP3A4

Cimetidine: Cimetidine inhibits both aldehyde oxidase (in vitro) and CYP3A4 (in vitro and in vivo), the primary and secondary enzymes, respectively, responsible for zaleplon metabolism. Concomitant administration of Sonata (10 mg) and cimetidine (800 mg) produced an 85% increase in the mean C_max and AUC of zaleplon. An initial dose of 5 mg should be given to patients who are concomitantly being treated with cimetidine.

Drugs Highly Bound to Plasma Protein

Zaleplon is not highly bound to plasma proteins (fraction bound 60%±15%); therefore, the disposition of zaleplon is not expected to be sensitive to alterations in protein binding. In addition, administration of Sonata to a patient taking another drug that is highly protein bound should not cause transient increase in free concentrations of the other drug.

Drugs with a Narrow Therapeutic Index

Digoxin: Sonata (10 mg) did not affect the pharmacokinetic or pharmacodynamic profile of digoxin (0.375 mg q24h for 8 days).

Warfarin: Multiple oral doses of Sonata (20 mg q24h for 13 days) did not affect the pharmacokinetics of warfarin (R+)- or (S-)-enantiomers or the pharmacodynamics (prothrombin time) following a single 25-mg oral dose of warfarin.

Drugs That Alter Renal Excretion

Ibuprofen: Ibuprofen is known to affect renal function and, consequently, alter the renal excretion of other drugs. There was no apparent pharmacokinetic interaction between zaleplon and ibuprofen following single dose administration (10 mg and 600 mg, respectively) of each drug. This was expected because zaleplon is primarily metabolized and renal excretion of unchanged zaleplon accounts for less than 1% of the administered dose.