Skelaxin: profile and news

UPDATE 2-King Pharmaceuticals profit falls, sales rise May 9, 2006
Tong said the results were led by strong gains in sales of heart drug Altace, which had net sales of $159 million, and muscle relaxant Skelaxin, which had net ... - Reuters

King Pharma adjusted net up 40%; sales up 31% May 9, 2006
Sales of the company's Altace hypertension medication shot up 85% to $159 million for the quarter, while muscle relaxant Skelaxin sales grew 37% to $99 million ... - MarketWatch

King Is in Control May 9, 2006
Sales of the blood pressure drug Altace, King's biggest product, rose 85% to $159 million. Sales of the muscle relaxant Skelaxin climbed 37% to $99 million. ... - TheStreet.com

King Pharma Q1 Adj. EPS Beats Street Expectations; Revenues Climb ... May 9, 2006
Net sales of Skelaxin (metaxalone), a drug indicated as an adjunct to rest, physical therapy, totaled $99 million during the first quarter of 2006, an increase ... - Trading Markets,

King Pharmaceuticals Reports First-Quarter 2006 Financial Results May 9, 2006
Net sales of Skelaxin(R) (metaxalone) totaled $99 million during the first quarter of 2006, an increase of 37% compared to $72 million during the same period ... - PR Newswire (press release),

Other information

Indication
For the treatment of painful musculoskeletal conditions

Pharmacology
Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

Mechanism Of Action
The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

Drug Category
Muscle Relaxants, skeletal muscle; Analgesics; Hypnotics and Sedatives;

Brand Names/Synonyms
.Meta.Xalon; .Meta.Xalone; .Meta.Zalone; .Meta.Zolone; AHR 438; AHR-438; HSDB 3236; Metassalone [Dcit]; Metaxalon; Metaxalona [Inn-Spanish]; Metaxalona [Spanish]; Metaxalone; Metaxalone [Usan:Ban:Inn]; Metaxalonum [Inn-Latin]; Metaxalonum [Latin]; Metazalone; Metazolone; Methaxalonum; Methoxolone; Skelaxin; Zorane

Dosage Forms
Tablet

Absorption
Not Available

Interactions
Interactions for Metaxalone:

SKELAXIN may enhance the effects of alcohol, barbiturates and other CNS depressants.

Chemical IUPAC Name
5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one

Chemical Formula
C12H15NO3

Half Life
9.2 (+/- 4.8) hours

Drug Type
Approved Drug

# Accession No
APRD00514

CAS Registry Number
1665-48-1