Silvadene: profile and news

Journal of Burn Care & Research Reports AQUACEL(R) Ag Hydrofiber(R ... May 15, 2006
...of adult and pediatric patients with partial thickness burns compared to a protocol of care including silver sulfadiazine (silvadene) cream, according to a ... - Yahoo! News (press release)

HEALING PROBLEM WOUNDS: SILVER TECHNOLOGY May 11, 2006
...process. One of the oldest treatments for chronic wounds has been silvadene cream, which is an antibiotic cream that has silver in it. ... - KFDM-TV News,

Studies Demonstrate The Benefits Of Convatec's Aquacel® Ag ... May 6, 2006
...including fewer dressing changes, reduced hospital length of stay, and better cost-effectiveness compared to silver sulfadiazine (silvadene) cream for the ... - Medical News Today (press release),

Other information

Indication
For the treatment of rheumatic fever and meningococcal meningitis

Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Mechanism Of Action
Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Drug Category
Antiprotozoals; Anti-Infectives; Anti-Infectives; ATC:D06BA01; ATC:J01EC02

Brand Names/Synonyms
A-306; Adiazin; Adiazine; Coco-Diazine; Cocodiazine; Codiazine; Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit; Diazyl; Eskadiazine; Honey Diazine; Lantrisul; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Metha-Meridiazine; Microsulfon; Neazine; Neotrizine; Palatrize; Pecta-Diazine, Suspension; Piridisir; Pirimal; Pyrimal; Quadetts; Quadramoid; RP 2616; S. N. 112; SDA; Sanodiazine; Sildaflo; Silvadene; Spofadrizine; Ssd; Sterazine; Sulfa-Triple #2; Sulfacombin; Sulfadiazene; Sulfadiazin; Sulfadiazine; Sulfaloid; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidin; Sulfapyrimidine; Sulfatryl; Sulfazin; Sulfazine; Sulfolex; Sulfonamides Duplex; Sulfonsol; Sulfose; Sulphadiazine; Terfonyl; Theradiazine; Thermazene; Tri-Sulfameth; Trifonamide; Triple Sulfa; Triple Sulfas; Triple Sulfoid; Trisem; Trisulfapyrimidine, Oral Suspension; Truozine

Dosage Forms
CREAM

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
4-amino-N-pyrimidin-2-yl-benzenesulfonamide

Chemical Formula
C10H10N4O2S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00190

CAS Registry Number
68-35-9