Seroquel: profile and news

I'm Bipolar Journal: December 2005-January 2006  16 May 2006
...by Marcia Purse. Between December 9th and the 31st I raised my Seroquel dose in 25 to 50 mg increments from 50 to 200 mg, then dropped it back to 175. ... - About - News & Issues,

Plaintiff claims Seroquel caused pancreatitis in federal suit  May 2, 2006
Billy Robbins filed a 10-count suit against AstraZeneca Pharmaceuticals alleging the prescription drug Seroquel caused her to develop pancreatitis. ... - Madison County Record,

AstraZeneca First-Quarter Net Rises 37% on Crestor, Seroquel  Apr 27, 2006
...largest drugmaker, said first-quarter profit increased 37 percent on rising sales of cholesterol treatment Crestor, anti- psychotic drug Seroquel and Nexium ... - Bloomberg

Seroquel big, and could get bigger  Apr 23, 2006
For pharmaceutical maker AstraZeneca, whose US shares are up about 24 percent in the past year, Seroquel is that leadoff hitter. ... - The News Journal,

Understanding and Managing Psychosis in Late Life  May 15, 2006
For older patients with schizophrenia or psychosis of AD, risperidone (Risperdal), olanzapine (Zyprexa) and quetiapine (Seroquel) are currently the three most ... - Psychiatric Times,

A rush to overprescribe?  May 1, 2006
Although the six drugs — Clozaril, Risperdal, Zyprexa, Seroquel, Abilify and Geodon — can be helpful in treating children with mental illness, critics say ... - USA Today

Students sent to hospital over antidepressants  May 12, 2006
The students, both males, took the antipsychotic medication Seroquel on Wednesday morning, Heather Mayo, Pitt County Schools' spokeswoman said. ... - Greenville Daily Reflector,

Cortlandt suicide victim used antipsychotic, wife says  May 2, 2006
He started taking Seroquel, an antipsychotic drug commonly used to treat bipolar disorder and schizophrenia, four days before the shootings, said William ... - The Journal News.com,

More kids on mental health medicines  May 3, 2006
...• At 24.8 percent, Seroquel had the largest share of the US market last year for atypical anti-psychotic drugs, larger than Eli Lilly & Co.'s Zyprexa (24.3 ... - The News Journal,

Following suit: More drugs coming under legal attack  Apr 21, 2006
The drugs now under attack include Seroquel, an antipsychotic medicine from AstraZeneca; Ortho-Evra, a birth-control patch from Johnson & Johnson; Prempro, a ... - International Herald Tribune,

Antipsychotic Drug Use Among Kids Soars  May 5, 2006
The drugs include Eli Lilly & Co.‘s Zyprexa, AstraZeneca PLC‘s Seroquel, Bristol-Myers Squibb Co.‘s Abilify and Pfizer Inc.‘s Geodon. - Ely Times,

AstraZeneca raises guidance after strong quarter  Apr 27, 2006
The Anglo-Swedish pharmaceutical company said that sales of five key drugs rose by 25 per cent, including Nexium, Seroquel, and Crestor. ... - MSN Money

AstraZeneca earnings rise, beat analysts' forecasts  Apr 27, 2006
AstraZeneca Plc. posted strong first-quarter profit Thursday and raised its earnings forecast for the year amid strong sales of Nexium, Seroquel and Crestor. ... - The News Journal,

AstraZeneca's profits leap ahead of sales growth  Apr 27, 2006
...a 36% increase in operating profits to $1.98 billion, helped by cost-cutting, as sales advanced 8%, driven by schizophrenia drug Seroquel and cholesterol ... - Pharma Times (subscription),

AstraZeneca Q1 tops forecast, ups 2006 outlook  Apr 27, 2006
...quarterly profits on Thursday and raised its earnings forecast for 2006, boosted by strong demand for established medicines such as Seroquel for schizophrenia. ... - MSN Money

AstraZeneca Q1 stronger than expected: raises FY targets  Apr 27, 2006
Combined sales of five key growth products -- Nexium, Seroquel, Crestor, Arimidex and Symbicort -- rose by 25 pct. ... Seroquel sales were 807 mln usd, up 29 pct. ... - Forbes

AstraZeneca posts record profits  Apr 27, 2006
...posted record quarterly profits on Thursday and raised its 2006 earnings forecast, boosted by demand for established drugs such as Seroquel for schizophrenia. ... - Reuters.uk,

UPDATE 3-AstraZeneca Q1 tops forecast, ups 2006 outlook  Apr 27, 2006
...profits on Thursday and raised its 2006 earnings forecast, boosted by demand for established drugs such as ulcer pill Nexium and Seroquel for schizophrenia. ... - Reuters

AstraZeneca prescribes record quarterly profits  Apr 27, 2006
...quarter came in at just under $6.2 billion, driven by the healthy rises in the drugmaker's set of five benchmark drugs: Nexium, Seroquel, Arimidex, Symbicort ... - Times Online,

Profits surge gives injection to GSK and AstraZeneca shares  Apr 27, 2006
Sales climbed 8 per cent to $6.18bn, driven by the stomach ulcer pill Nexium, Seroquel for schizophrenia and the cholesterol drug Crestor. ... - Independent,

AstraZeneca CFO 'confident' FY operating margin will be at least ...  Apr 27, 2006
In the first quarter strong sales of key products including anti-psychotic Seroquel, stomach ulcer drug Nexium and asthma treatment Seroquel helped drive growth ... - Forbes

Drugs giants hit heights on forecast-beating Q1 results  Apr 27, 2006
...quarterly profits and raised its earnings forecast for 2006 - helped by demand for established drugs such as ulcer pill Nexium and Seroquel for schizophrenia. ... - Scotsman,

AstraZeneca announces 38-percent jump in first-quarter profit  Apr 27, 2006
Astrazeneca said that combined sales of five key growth products -- Nexium, Seroquel, Crestor, Arimidex and Symbicort -- soared by 25 percent. ... - TODAYonline,

Adult anti-psychotics can worsen troubles  May 1, 2006
These six new anti-psychotic drugs — Clozaril, Risperdal, Zyprexa, Seroquel, Abilify and Geodon — are not approved for children, but doctors can prescribe ... - USA Today

New York Times Examines 'Next Wave' of Patient Lawsuits Over ...  Apr 25, 2006
The medications, which have combined annual sales of $7 billion, include the antipsychotic Seroquel, manufactured by AstraZeneca; the birth control patch Ortho ... - Kaiser network.org,

AstraZeneca set for results record  Apr 22, 2006
Nexium, its medicine for heartburn and stomach ulcers, cholesterol drug Crestor and schizophrenia medicine Seroquel have all enjoyed exceptional growth this ... - Telegraph.co.uk,

Attorney David F. Ennis of Ennis & Ennis, PA Speaks Out About ...  Apr 18, 2006
Three drugs he mentioned by name were the antipsychotic drugs Zyprexa, Risperdal, and Seroquel. Currently his law firm is handling ... - The Open Press (press release)

Army Acts to Curb Abuses of Injured Recruits  May 12, 2006
...wearing a patch with the painkiller fentanyl, which he called "80 times stronger than heroin," and also wrote: "The Army has me on Ambien, seroquel, tylox and ... - The Ledger,

Behavioral and Pharmacologic Treatment of Aggression in Children ...  May 10, 2006
Clozapine (Clozaril), quetiapine (Seroquel), olanzapine (Zyprexa) and ziprasidone (Geodon) have been evaluated in small or uncontrolled studies and case ... - Psychiatric Times,

AstraZeneca PLC: First Quarter Results 2006  Apr 27, 2006
Combined sales of 5 key growth products (Nexium™, Seroquel™, Crestor™, Arimidex™ and Symbicort™) increased by 25 percent. ... - PharmaLive.com (press release),

AstraZeneca lifts guidance as net profit climbs  Apr 27, 2006
Of key drugs, Nexium sales improved 16% to $1.19 billion, Crestor sales rose 45% to $387 million and Seroquel sales advanced 29% to $807 million. ... - MarketWatch

Healthy drug sales at AstraZeneca  Apr 27, 2006
Sales jumped 8% to $6.18bn, with breast cancer drug Arimidex, schizophrenia treatment Seroquel and cholesterol fighter Crestor seeing rapid growth. ... - BBC News,

WRAPUP 1-Healthy UK drugmakers smash Q1 profit forecasts  Apr 27, 2006
Plc (AZN.L: Quote, Profile, Research) profits leapt 38 percent -- against the 23 percent expected -- fuelled by US demand for its Seroquel, Crestor and Nexium ... - Reuters

Healthy drugmakers smash profit forecasts  Apr 27, 2006
AstraZeneca profits leapt 38 percent -- against the 23 percent expected -- fuelled by US demand for its Seroquel, Crestor and Nexium drugs. ... - Scotsman,

US venture for AstraZeneca  Apr 27, 2006
AstraZeneca said the combined sales of its five key products - heartburn drug Nexium; antipsychotic Seroquel; cholesterol medicine Crestor; cancer treatment ... - Telegraph.co.uk,

Record quarter boosts AstraZeneca  Apr 27, 2006
It said the combined sales of five of its key products - Nexium, Seroquel, Crestor, Arimidex and Symbicort - increased by 25% during the period. ... - CityWire.co.uk,

Disabled, Seniors Confront Medicare Hole  Apr 27, 2006
She said she‘ll worry about the ramifications later since she cannot afford to skip taking her Seroquel, which is used to control bipolar disorder. ... - Herald News Daily,

AstraZeneca Says Profit Rises 37 Percent  Apr 27, 2006
The drugmaker said that the combined sales of its five key products — heartburn drug Nexium, antipsychotic Seroquel, cholesterol medicine Crestor, cancer ... - Ely Times,

AstraZeneca CFO 'confident' FY operating margin will be at least ...  Apr 27, 2006
Strong sales of key products including anti-psychotic Seroquel, stomach ulcer drug Nexium and asthma treatment Seroquel helped drive growth, particularly in ... - Forbes

AstraZeneca set for results record  Apr 23, 2006
Nexium, its medicine for heartburn and stomach ulcers, cholesterol drug Crestor and schizophrenia medicine Seroquel have all enjoyed exceptional growth this ... - Therapeutics Daily (subscription) (press release),

Global pharma sales up 9.3% in January  Apr 17, 2006
International sales growth for PFE's Lipitor accelerated to +8% in February, while sales growth of AZN's Nexium, Seroquel and Crestor was robust, UBS adds. ... - newratings.com

Glaxo, AstraZeneca First-Quarter Profits Increase; Shares Rise  Apr 27, 2006
AstraZeneca's first-quarter profit was driven by sales of cholesterol treatment Crestor, anti-psychotic drug Seroquel and Nexium for ulcers. ... - Bloomberg

AstraZeneca drops diabetes drug Galida  May 4, 2006
...are currently growing strongly, boosted by cost savings and strong sales of established medicines such as ulcer pill Nexium and Seroquel for schizophrenia. ... - MSN Money

AstraZeneca scraps development of diabetes drug  May 4, 2006
...quarter, are currently growing strongly, boosted by cost savings and strong sales of established drugs such as ulcer pill Nexium and Seroquel for schizophrenia ... - Reuters

New anti-psychotic drugs carry risks for children  May 1, 2006
None of the six drugs — Clozaril, Risperdal, Zyprexa, Seroquel, Abilify and Geodon — is approved for kids, but doctors can prescribe them as "off-label ... - USA Today

AstraZeneca Q1 Profit Up; EPS Tops Estimates, FY06 Outlook Up ...  Apr 27, 2006
...basis. Combined sales of five key growth products namely, Nexium, Seroquel, Crestor, Arimidex and Symbicort, increased by 25%. During ... - Trading Markets,

Chamber of Commerce billboards attack Byrum  May 3, 2006
...lawsuits include Ortho-Evra, a birth-control patch made by Johnson & Johnson; Fosamax, a Merck-produced osteoporosis medicine; and Seroquel, an antipsychotic ... - Lansing State Journal,

Diabetes drug trials to be halted  May 5, 2006
...once was seen as a potential blockbuster for the company, supplementing billion-dollar-plus sellers like Nexium drug for acid reflux and Seroquel, a treatment ... - The News Journal,

The risks of using SEROQUEL in combination with other drugs have not been extensively evaluated in systematic studies. Given the primary CNS effects of SEROQUEL, caution should be used when it is taken in combination with other centrally acting drugs. SEROQUEL potentiated the cognitive and motor effects of alcohol in a clinical trial in subjects with selected psychotic disorders, and alcoholic beverages should be avoided while taking SEROQUEL.

Because of its potential for inducing hypotension, SEROQUEL may enhance the effects of certain antihypertensive agents. SEROQUEL may antagonize the effects of levodopa and dopamine agonists.

The Effect of Other Drugs on Quetiapine

Phenytoin: Coadministration of quetiapine (250 mg tid) and phenytoin (100 mg tid) increased the mean oral clearance of quetiapine by 5-fold. Increased doses of SEROQUEL may be required to maintain control of symptoms of schizophrenia in patients receiving quetiapine and phenytoin, or other hepatic enzyme inducers (e.g., carbamazepine, barbiturates, rifampin, glucocorticoids). Caution should be taken if phenytoin is withdrawn and replaced with a non-inducer (e.g., valproate).

Divalproex: Coadministration of quetiapine (150 mg bid) and divalproex (500 mg bid) increased the mean maximum plasma concentration of quetiapine at steady state by 17% without affecting the extent of absorption or mean oral clearance.

Thioridazine: Thioridazine (200 mg bid) increased the oral clearance of quetiapine (300 mg bid) by 65%.

Cimetidine: Administration of multiple daily doses of cimetidine (400 mg tid for 4 days) resulted in a 20% decrease in the mean oral clearance of quetiapine (150 mg tid). Dosage adjustment for quetiapine is not required when it is given with cimetidine.

P450 3A Inhibitors: Coadministration of ketoconazole (200 mg once daily for 4 days), a potent inhibitor of cytochrome P4503A, reduced oral clearance of quetiapine by 84%, resulting in a 335% increase in maximum plasma concentration of quetiapine. Caution is indicated when SEROQUEL is administered with ketoconazole and other inhibitors of cytochrome P450 3A (e.g., itraconazole, fluconazole, and erythromycin).

Fluoxetine, Imipramine, Haloperidol, and Risperidone: Coadministration of fluoxetine (60 mg once daily); imipramine (75 mg bid), haloperidol (7.5 mg bid), or risperidone (3 mg bid) with quetiapine (300 mg bid) did not alter the steady-state pharmacokinetics of quetiapine.

Effect of Quetiapine on Other Drugs

Lorazepam: The mean oral clearance of lorazepam (2 mg, single dose) was reduced by 20% in the presence of quetiapine administered as 250 mg tid dosing.

Divalproex: The mean maximum concentration and extent of absorption of total and free valproic acid at steady state were decreased by 10 to 12% when divalproex (500 mg bid) was administered with quetiapine (150 mg bid). The mean oral clearance of total valproic acid (administered as divalproex 500 mg bid) was increased by 11% in the presence of quetiapine (150 mg bid). The changes were not significant

Lithium: Concomitant administration of quetiapine (250 mg tid) with lithium had no effect on any of the steady-state pharmacokinetic parameters of lithium.

Antipyrine: Administration of multiple daily doses up to 750 mg/day (on a tid schedule) of quetiapine to subjects with selected psychotic disorders had no clinically relevant effect on the clearance of antipyrine or urinary recovery of antipyrine metabolites. These results indicate that quetiapine does not significantly induce hepatic enzymes responsible for cytochrome P450 mediated metabolism of antipyrine.