Secobarbital: profile and news

The perils of self-prescription May 5, 2006
...popular with UK buyers but top-sellers internationally include amphetamines, opoids such as oxycodone, benzodiazepines, even fentanyl and secobarbital, all of ... - Financial Times,

Other information

Indication
For the Short-term treatment of intractable insomnia for patients habituated to barbiturates

Pharmacology
Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Mechanism Of Action
Secobarbital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Drug Category
Hypnotics and Sedatives; Adjuvants; Barbiturates; ATC:N05CA06

Brand Names/Synonyms
Seconal (TN); Secobarbital (USP); Novosecobarb; Barbosec; Bipanal; Bipinal sodium; CHEMBANK2949; DEA No. 2315; DEA No. 2316; Evronal; Evronal Sodium; Evrronal; HSDB 3182; Hypotrol; Hyptran; Imesonal; Immenoctal; Immenox; Meballymal; Meballymal sodium; Meballymalum; Pramil; Quinalbarbital; Quinalbarbitone; Quinalbarbitone sodium; Quinalspan; Sebar; Seco 8; Secobarbital; Secobarbital Sodium; Secobarbital [USAN:INN]; Secobarbital suppository dosage form; Secobarbitale [DCIT]; Secobarbitalum [INN-Latin]; Secobarbitone; Seconal; Seconal Sodium; Sedutain; Seotal; Sodium Secobarbital; Sodium Seconal; Sodium quinalbarbitone; Somosal; Synate; Trisomnin; (+/-)-Secobarbital; EINECS 200-982-2; Secobarbital (USP); Seconal (TN)

Dosage Forms
CAPSULE

Absorption
Not Available

Interactions
Interations Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.

Chemical IUPAC Name
5-(1-methylbutyl)-5-prop-2-enyl-hexahydropyrimidine-2,4,6-trione

Chemical Formula
C12H18N2O3

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00497

CAS Registry Number
76-73-3