Scopolamine: profile and news

The Scopolamine Addiction Apr 25, 2006
Everyone already knows the tense bewilderment brought about by Mahler's symphonies, the musical mathematics of Tool's guitar cords, the sexual magnetism of ... - Mass Media (subscription),

Why is DOD Ignoring Heroic Vets? May 13, 2006
...by the government for their roles in this research using chemical weapons such as Sarin, BZ, mustard agents, nerve agents, drugs such as LSD, PCP, scopolamine. ... - Political Cortex,

Seasick without the sea May 4, 2006
Other medications CDC recommends are scopolamine, oral meclizine (Bonine, Antivert or another form of Dramamine), diphenhydramine (Benadryl) and promethazine. ... - The Casper Star Tribune,

The big queasy May 1, 2006
Behind-the-ear patches containing scopolamine now control her motion sickness under most circumstances, but not on the Riddler's Revenge ride at Six Flags ... - Arizona Republic,

Other information

Indication
Excessive salivation;Colicky abdominal pain;Bradycardia;Sialorrhoea;Diverticulitis;Irritable bowel syndrome;Motion sickness

Pharmacology
Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopolamine also may work directly on the vomiting center. Scopolamine must be taken before the onset of motion sickness to be effective.

Mechanism Of Action
Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Drug Category
Mydriatics; Adjuvants; Antimuscarinics; Antispasmodics; ATC:A03BB01; ATC:A03BB03; ATC:A04AD01; ATC:N05CM05; ATC:S01FA02; ATC:S01FA03

Brand Names/Synonyms
Atrochin; Atroquin; Atroscine Hydrobromide; Beldavrin; Buscopan; CHEMBANK933; Epoxytropine Tropate; Euscopol; Hydroscine Hydrobromide; Hyocine F Hydrobromide; Hyosceine; Hyoscine; Hyoscine Bromide; Hyoscine Hydrobromide; Hyoscyine Hydrobromide; Hyosol; Hysco; Isopto Hyoscine; Isoscopil; Kwells; L-Hyoscine Hydrobromide; L-Scopolamine; Methscopolamine Bromide; Oscine; Pamine; SEE; Scop; Scopamin; Scopine Tropate; Scopoderm-Tts; Scopolamine; Scopolamine Bromide; Scopolamine Hydrobromide; Scopolamine Hydrobromide Trihydrate; Scopolamine Hyoscine; Scopolaminhydrobromid; Scopolaminium Bromide; Scopolammonium Bromide; Scopos; Sereen; Skopolamin; Tranaxine; Transcop; Transderm Scop; Transderm-Scop; Transderm-V; Triptone; Tropic Acid, Ester with Scopine

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Interactions for Scopolamine:

The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased gastric motility and delayed gastric emptying.

Scopolamine should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Scopolamine will interfere with the gastric secretion test.

Chemical IUPAC Name
Not Available

Chemical Formula
C17H21NO4

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00616

CAS Registry Number
6533-68-2