Retin-A: profile and news






'Allure' changes beauty business  16 May 2006
Some of the big milestones to push the industry along since 1991 were the introduction of Retin-A and Botox treatments. When Retin ... - Jackson Clarion Ledger,

Scripps Howard News Service  16 May 2006
FATCATS (Fuoco, Pittsburgh Post-Gazette) _ In this era of pet resorts, doggie yoga, feng shui pet gardens and Retin-A acne treatments for cats, it was just a ... - Scripps Howard News Service,

Veterinarians now using Retin-A to treat acne on cats  May 3, 2006
While human topical products including topical retinoids such as Retin-A, benzoyl peroxides such as Oxydex gel have been used with good success, it is ... - Fort Wayne News Sentinel,

Kathy Lette - What I spend my money on  May 15, 2006
...pack of party animals. Beauty comes from within all right … within a jar marked "Retin-A Wrinkle Remover". Beauty, it would seem ... - The Herald,

AP Pharma Reports 2006 First Quarter Results; Phase 3 Clinical ...  May 10, 2006
During the quarter, the Company completed the sale of its interests in royalties on sales of Retin-A Micro(R) and Carac(R) effective October 1, 2005. ... - PharmaLive.com (press release),

No Time for Any Wrinkles  May 14, 2006
She began applying Retin-A (trans-retinoic acid) daily to wrinkle-prone areas of her face at 28, well before the vitamin-A derivative became widely accepted as ... - Standard-Speaker,

Be wary of silicone injectables for lip  Apr 18, 2006
As for Retinol A, I believe you may be asking about Retin A. Retin A is a vitamin A derivative and is good for improving fine lines, not deeper lines that are ... - Miami Herald,

With over-the-counter products, get a million-dollar appearance ...  Apr 20, 2006
Rx: Retinoids, vitamin A derivatives, are commonly known by their brand names such as Retin-A, Avage and Renova, and are prescribed to address fine lines. ... - DetNews.com,

What Is Cystic Acne and How to Treat This Acne  Apr 21, 2006
Tretinoin (Avita, Retin-A, Renova) and adapalene (Differin) are examples of topical prescription products for cystic acne derived from vitamin A. They work by ... - Fashion Monitor Toronto,

Sun Now, Dermatologist Later  Apr 28, 2006
A menu of prescription skin remedies, from Retin-A to the psoriasis drug, Tazorac, can help prevent sun damage skin from turning into cancer says Dr. Murray. ... - WFIE-TV,

Fat cats, hog dogs  May 8, 2006
In this era of pet resorts, doggie yoga, feng shui pet gardens and Retin-A acne treatments for cats, it was just a matter of time. ... - Pittsburgh Post Gazette,

Ages-old practice of threading exerts growing pull  May 8, 2006
Threading is recommended for women who use Retin-A for wrinkles or Acutane for acne because their skin is more fragile and waxing can pull off layers of skin. ... - Wisconsin State Journal,

Tap into the practical wisdom of Lucky's beauty editor, Jean ...  May 6, 2006
I'm convinced that's why Pro-Active is so successful. I use Retin A. It takes care of both of my problems: breakouts and wrinkles. ... - Houston Chronicle,

Treatment Options Help Prevent Skin Cancer  Apr 28, 2006
Murray said prescription skin remedies ranging from Retin-A to the psoriasis drug Tazorac can help prevent sun damage from turning into cancer. ... - WBAL Channel.com,

Prescriptions can assist acne cases where OTC options fail  Apr 23, 2006
Med Spa. Retinoids like Differin and Retin-A are derivatives of vitamin A that help create a new skin surface, she said. They treat ... - Monitor,

Nature's bounty is the buzz at the cosmetics counter  Apr 30, 2006
Close, also an aromatherapist and founder of the holistic spa Naturopathica in East Hampton, NY, says that the acne treatment Retin-A is based on vitamin A ... - Seattle Times,

Skin Deep Take 10 Years Off My Face, in 60 Seconds  Apr 20, 2006
Traditional skin care items, including prescription creams like Retin-A, take one to three months to show any kind of result because of the time needed for ... - New York Times,

BLINDED BY SCIENCE?  Apr 30, 2006
Commonly known as cosmeceuticals -- a word coined in 1980 by Dr. Albert Kligman, inventor of the acne/wrinkle cream Retin-A -- the high-end lotions now account ... - San Francisco Chronicle,


Other information


Indication
For topical treatment of cutaneous lesions in patients with AIDS- related Kaposi sarcomaia.

Pharmacology
Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS- related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.

Mechanism Of Action
Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.

Drug Category
Antineoplastic Agents; ATC:L01XX22

Brand Names/Synonyms
Alitretinoin; Alitretinoin [Usan]; Avita; Beta-Retinoic Acid; Panretin; Panretin Gel; Panretyn; Panrexin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Trans-Retinoic Acid; Tretin M; Tretinoin; Vesanoid; Vitamin a Acid

Dosage Forms
Not Available

Absorption
Not Available

Interactions
Interactions for Alitretinoin:

Patients who are applying Panretin® gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased DEET toxicity when DEET was included as proof of the formulation. Although there was no clinical evidence in the vehicle-controlled studies of drug interactions with systemic antiretroviral agents, including protease inhibitors, macrolide antibiotics, and azole antifungals, the effect of Panretin® gel on the steady-state concentrations of these drugs is not known. No drug interaction data are available on concomitant administration of Panretin® gel and systemic anti-KS agents.



Chemical IUPAC Name
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoicacid

Chemical Formula
C20H28O2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00017

CAS Registry Number
3/8/5300

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