Restoril: profile and news

Cover Story: Can't fall asleep? May 15, 2006
Hypnotics (including Restoril, Halcion, and Klonipin) should be used only in selected patients because they are potent medications that have severe side effects ... - Tucson Citizen,

Xanax: Covered or Not Covered? Apr 19, 2006
...cover Benzodiazepines and medicines falling under this category are Serax, Tranxene-SD, Valium, Xanax, Intensol, Paxipam, ProSom, Restoril, Klonipon, Librium ... - LiveArticles.org,

New weapons in travelers' round-the-clock jet-lag fight Apr 21, 2006
That may be because the drugs stay in the body for briefer periods than the older pills such as Dalmane (flurazepam) and Restoril (temazepam), among others ... - Los Angeles Times,

Addiction devastates two families Apr 25, 2006
...тАЬI warned him about messing around with that,тА? Potts said. тАЬHe ended up on high doses of Methadone, Restoril and OxyContin. ... - Frontiersman (subscription),

Other information

Indication
For the short-term treatment of insomnia (generally 7-10 days).

Pharmacology
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.

Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Drug Category
Anti-anxiety Agents; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05CD07

Brand Names/Synonyms
Apo-Temazepam; Cerepax; Crisonar; ER 115; Euhypnos; Euipnos; Gelthix; Hydroxydiazepam; K-3917; Levanxene; Levanxol; Levanzene; Mabertin; Methyloxazepam; N-Methyloxazepam; Normison; Novo-Temazepam; Oxydiazepam; Perdorm; Planum; Remestan; Restoril; Signopam; Temaz; Temazepam; WY 2917; Wy-3917

Dosage Forms
CAPSULE (7.5 mg, 15 mg, and 30 mg)

Absorption
Well absorbed, minimal first-pass metabolism.

Interactions
Interactions for Temazepam:

The pharmacokinetic profile of temazepam does not appear to be altered by orally administered cimetidine dosed according to labeling.

Chemical IUPAC Name
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one

Chemical Formula
C16H13ClN2O2

Half Life
10-20 hours

Drug Type
Approved Drug

# Accession No
APRD00676

CAS Registry Number
846-50-4