ReVia: profile and news






Revia (naltrexone) Gets an A as Treatment For Alcoholism  May 2, 2006
CHARLESTON, SC, May 2- Revia (naltrexone) with behavioral counseling in a primary care setting has emerged at the top of the heap for alcoholism treatment ... - MedPage Today,

Schuckit Addresses State-of-the-Art Addiction Treatments  May 14, 2006
...drinking. Another medication Schuckit recommends for alcohol withdrawal is naltrexone (ReVia), a pure opioid antagonist. Naltrexone ... - Psychiatric Times,

One of two available alcoholism drugs works-study  May 2, 2006
Naltrexone, sold generically in daily pill form under the brand name ReVia by Barr Pharmaceuticals Inc., was effective, while acamprosate, marketed under the ... - Reuters

Field of dreams? In Thorndale, those dreams are being realized  May 10, 2006
...average. Junior shortstop Austin Falke is second at .563, junior left fielder Kalen Revia is eighth at .514 and Culp ninth at .493. ... - Austin American-Statesman (subscription),

Have a drinking problem? Why not try drugs!  Apr 19, 2006
There are a range of drugs from ReVia -- which hasn't shown great strides because it must be taken daily, a hard choice for many alcoholics -- to Antabuse -- a ... - ProgressiveU.org,

Drinking Problem? Try Drugs  Apr 19, 2006
Some drugs are available now to treat alcoholism, including ReVia, which has had limited success because it must be taken daily -- an obstacle for some ... - Wired News

Older Drug Helps Alcoholics Abstain  May 2, 2006
This included either the drug naltrexone (ReVia), which was approved by the FDA for promoting alcohol abstinence in 1994, the drug acamprosate (Campral ... - WebMD

Reinventing Rehab  Apr 19, 2006
In alcohol treatment, there are relatively new drugs naltrexone (Revia) and acamprosate (Campral) that are said to help reduce cravings. ... - Forbes

Lawrence County takes county softball title  Apr 24, 2006
...scored a run. The Lady Bobcats got singles from Sarah Bowling and Revia Brown. Bowling had Speake’s lone RBI. Sparkman 5, Athens ... - The Decatur Daily,

Hubbard's golf continues to roll Athens softball team wins 40th ...  Apr 19, 2006
Revia Brown had a single, a double, and two RBIs; Whitney Sparks had two singles, a double, and two RBIs; Kayla black had two singles and three RBIs; Paige ... - The Decatur Daily,

Medley, Franks lead East Limestone to 22nd softball shutout of the ...  Apr 27, 2006
Cowart had a double, and George, Hensley and Erin Gillott each singled. Speake 7, Meek 2: Revia Brown and Paige Atkins each homered for Speake (27-11). ... - The Decatur Daily,

Palm Beach County news briefs  Apr 21, 2006
Palm School's 600 students were ushered outside after staffers noticed a paint-like odor in the administration office around 2 pm, principal Revia Lee said. ... - Sun-Sentinel.com,

East Limestone takes county softball title  Apr 23, 2006
Speake 7, Lawrence County 6: For Speake, Revia Brown, Sarah Bolan and Paige Atkins each had two singles. Bolan and Atkins each drove in two runs. ... - The Decatur Daily,


Other information


Indication
For treatment of opioid type drug dependence.

Pharmacology
Naltrexone, a pure opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. Naltrexone is indicated in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids. It markedly attenuates or completely blocks, reversibly, the subjective effects of intravenously administered opioids. When co-administered with morphine, on a chronic basis, Naltrexone blocks the physical dependence to morphine, heroin and other opioids. In subjects physically dependent on opioids, Naltrexone will precipitate withdrawal symptomatology.

Mechanism Of Action
Naltrexone binds to the opioid mu receptor antagonistically, thereby preventing conventional opiate (heroin, morphine) drugs from binding and inducing opioid neural responses. The mechanism of action of Naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids.

Drug Category
Anti-craving Agents; Depressants; Alcohol Antagonists; Opiate Antagonists; ATC:N07BB04

Brand Names/Synonyms
CCRIS 3506; Celupan; HSDB 6750; N-Cyclopropylmethylnoroxymorphone; Naltrexona [Inn-Spanish]; Naltrexone; Naltrexone Hcl; Naltrexone [Usan:Ban:Inn]; Naltrexonum [Inn-Latin]; Revia; UM-792; Vivitrex

Dosage Forms
TABLET

Absorption
Not Available

Interactions
Interactions for Naltrexone:

Studies to evaluate possible interactions between REVIA and drugs other than opiates have not been performed. Consequently, caution is advised if the concomitant administration of REVIA and other drugs is required.

The safety and efficacy of concomitant use of REVIA and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.

Lethargy and somnolence have been reported following doses of REVIA and thioridazine.

Patients taking REVIA may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics. In an emergency situation when opioid analgesia must be administered to a patient receiving REVIA, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.



Chemical IUPAC Name
Not Available

Chemical Formula
C20H23NO4

Half Life
4 hours

Drug Type
Approved Drug

# Accession No
APRD00005

CAS Registry Number
16590-41-3

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