Piperazine: profile and news

ImQuest Pharmaceuticals Licenses Piperazine Series of Anti-Cancer ... Apr 26, 2006
The piperazine series has been shown in both cell based and small animal model anti-cancer studies performed by the National Cancer Institute (NCI, USA) and ... - Yahoo! News (press release)

Side-effect warning on BZP-based ‘party pills’ Apr 17, 2006
The National Poisons Centre predicts that doses over a total of 250mg of a piperazine-based designer drug would likely cause moderate toxicity, such as anxiety ... - Gisborne Herald,

ImQuest licenses anticancer compounds from Samjin Apr 27, 2006
The piperazine series has been shown in both cell-based and small animal model anticancer studies to have significant and diverse biological anti-tumor ... - Pharmaceutical Business Review

Other information

Indication
Used as alternative treatment for ascariasis caused by Ascaris lumbricoides(roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm).

Pharmacology
Piperazine is an antinematodal agent indicated as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). Piperazine is especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children.

Mechanism Of Action
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Drug Category
Antinematodal Agents; Anthelmintics; ATC:P02CB01; ATC:R03DA09

Brand Names/Synonyms
Anatensol; Antepan; Antepar; Antiren; Asca-Trol No. 3; Bryrel; Dapotum; Diethylenediamine; Diethyleneimine; Dispermine; Entacyl; Eraverm; Fluphenazine Dihydrochloride; Hexahydropyrazine; Lumbrical; Lyogen; Moditen; Multifuge; Omca; Pacinol; Permitil; Piperazidine; Piperazin; Piperazine; Piperazine Anhydrous; Piperazine Citrate; Piperazine, Anhydrous; Pipersol; Prolixin Decanoate; Pyrazine Hexahydride; Pyrazine, Hexahydro-; Siqualone; Tasnon; Tensofin; UN 2579; Upixon; Uvilon; Valamina; Vermex; Vermidol; Worm-Away; Wurmirazin

Dosage Forms
CAPSULE; DROPS; LIQUID; POWDER; POWDER FOR SOLUTION; SOLUTION; SUSPENSION; SYRUP; TABLET

Absorption
Rapidly absorbed from the gastrointestinal tract

Interactions
Not Available

Chemical IUPAC Name
piperazine

Chemical Formula
C4H10N2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00225

CAS Registry Number
110-85-0