Phenylbutazone: profile and news

NSAIDs: Pain Relief or Pain in the Gut? May 2, 2006
The NSAIDs most commonly used in horses include phenylbutazone ("Bute"), meclofenamic acid (Arquel), flunixin meglumine (Banamine), ketoprofen (Ketofen), and ... - TheHorse.com,

Wound care for sales horses May 9, 2006
It's also important to give an anti-inflammatory, such as Bute [phenylbutazone] or steroids, in moderation, because in some cases this can prevent some of the ... - Thoroughbred Times,

24 hours till 'go' time May 7, 2006
The private veterinarian who works for a trainer will go to the stall and give the horse an injection, most commonly phenylbutazone or "bute.". ... - Louisville Courier-Journal,

Rolex Talk Highlights Performance Horse Issues May 3, 2006
Phenylbutazone is just as good in moderation- Oklahoma State University researchers have determined that a four gram dose of Bute gives no additional benefit ... - TheHorse.com,

Kentucky Issues Advisory on Naproxen Use Apr 20, 2006
...the time the horse is to race. The three NSAIDS are phenylbutazone, flunixin, and ketoprofen. The rule also states that all other ... - TheHorse.com,

Other information

Indication
For the treatment of backache and ankylosing spondylitis

Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Mechanism Of Action
Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Drug Category
Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:M01AA01; ATC:M02AA01

Brand Names/Synonyms
'Esteve'; A 7514; Alindor; Alka Butazolidin; Alkabutazona; Alqoverin; Ambene; Anerval; Anpuzone; Antadol; Anuspiramin; Apo-Phenylbutazone; Arthrizon; Artizin; Artrizin; Artrizone; Artropan; Azdid; Azobutyl; Azolid; B.T.Z.; Benzone; Betazed; Bizolin; Bizolin 200; Bunetzone; Busone; Buta Phen; Butacompren; Butacote; Butadion; Butadiona; Butadione; Butagesic; Butalan; Butalgina; Butalidon; Butaluy; Butapirazol; Butapirazole; Butapyrazole; Butarecbon; Butartril; Butartrina; Butatron; Butazina; Butazolidin; Butazolidine; Butazona; Butazone; Bute; Butidiona; Butiwas-Simple; Butone; Butoz; Butylpyrin; Buvetzone; Buzon; Chembutazone; Cotylbutazone; DA-192; Digibutina; Diossidone; Diozol; Diphebuzol; Diphenylbutazone; Ecobutazone; Elmedal; Equi Bute; Equipalazone; Eributazone; Exrheudon N; Febuzina; Fenartil; Fenibutal; Fenibutasan; Fenibutazona; Fenibutol; Fenilbutazona; Fenilbutina; Fenilbutine; Fenilidina; Fenotone; Fenylbutazon; Flexazone; G 13, 871; Ia-But; Intalbut; Intrabutazone; Intrazone; Ipsoflame; Kadol; Lingel; Malgesic; Mepha-Butazon; Mephabutazon; Mephabutazone; Merizone; NCI-C55414; Nadazone; Nadozone; Neo-Zoline; Novophenyl; PBZ; Phebuzin; Phebuzine; Phenbutazol; Phenbutazone; Phenopyrine; Phenyl-Mobuzon; Phenylbutaz; Phenylbutazone; Phenylbutazonum; Phenyzene; Phenyzone; Pirarreumol &Quot;B&Quot;; Pirarreumol B; Praecirheumin; Pyrabutol; Pyrazolidin; Rectofasa; Reudo; Reudox; Reumasyl; Reumazin; Reumazol; Reumune; Reumuzol; Reupolar; Robizon-V; Robizone; Robizone-V; Rubatone; Scanbutazone; Schemergin; Shigrodin; Tazone; Tencodyne; Tetnor; Tevcodyne; Therazone; Ticinil; Todalgil; Usaf Ge-15; Uzone; VAC-10; Wescozone; Zolaphen; Zolidinum; Zorane

Dosage Forms
BOLUS; LIQUID; PASTE; POWDER; SOLUTION; TABLET

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione

Chemical Formula
C19H20N2O2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00409

CAS Registry Number
50-33-9