Phenergan: profile and news






Phenergan should be a controlled drug!  May 15, 2006
Has anyone ever had to take Phenergan, also known as Promethazine or Promethagan??? ... Know any one who talks about Phenergan like it's a "great" drug? ... - ProgressiveU.org,

Phenergan Rarely Used for Stomach Flu Nausea  May 6, 2006
Phenergan is also sometimes used by drug abusers to enhance their highs from opium-derived painkillers, such as OxyContin and Vicodin, said Dr. Bankole Johnson ... - Los Angeles Times,

A Closer Look: Ambien and Phenergan  May 5, 2006
Details about the two prescription drugs, Ambien and Phenergan, that Rep. ... Patients taking Phenergan should not drive or operate heavy machinery. ... - Guardian Unlimited,

Warning issued about Phenergan antihistamine  Apr 26, 2006
The drug, also known as promethazine HCl, is sold by Wyeth under the brand name Phenergan as well as in various generic versions. ... - Chicago Sun-Times,

A Closer Look: Ambien and Phenergan  May 5, 2006
The drug can cause drowsiness, dizziness and occasional blurred vision. Patients taking Phenergan should not drive or operate heavy machinery. ... - Herald News Daily,

Patrick Kennedy Is A Typical Whiny Drug Addict  May 13, 2006
...the crash. Later Kennedy claimed that he had only taken the sleep medication Ambien and the anti-nausea drug Phenergan. Kennedy ... - American Daily,

A Closer Look: Ambien and Phenergan  May 5, 2006
Details about the two prescription drugs, Ambien and Phenergan, that Rep. ... Details about the two prescription drugs, Ambien and Phenergan, that Rep. ... - Minneapolis Star Tribune (subscription),

IN THE NEWS  May 9, 2006
The US Food and Drug Administration is warning parents and physicians to stop giving the allergy drug promethazine HCl (also known as Phenergan) to children ... - Parents.com

Sleepwalking Into History, Kennedy Style  May 15, 2006
Rather than cop to drinking, Kennedy claimed he had no memory of the incident because of an interaction between "the prescribed amount of Phenergan and Ambien ... - Reason Online,

Patrick Kennedy Crashes Car Into a Capitol Hill Barrier  May 5, 2006
The congressman said he had also been taking Phenergan, an anti-nausea medication, as well as Ambien. Phenergan is sometimes used ... - New York Times,

John Anderson: Kennedys keep getting special treatment  May 9, 2006
He admitted to taking Phenergan for gastrointestinal problems and Ambien, a sleeping medication, and said he became disoriented and was driving to the Capitol ... - The Capital Times,

More on the drugs Rep. Kennedy blames  May 5, 2006
Patrick Kennedy is blaming his Capitol Hill car crash early Thursday on a combination of two medications, Ambien to sleep and anti-nausea drug Phenergan for a ... - USA Today

Patrick Kennedy's Psychedelic Freak Out!  May 5, 2006
If you’ll recall, Kennedy’s excuse for the accident was taking Phenergan in combination with Ambien. He’s not the first to mix that particular cocktail: ... - Yahoo! News

Kennedy to enter rehab  May 5, 2006
...said. He has admitted only to taking the prescribed doses of Phenergan to treat a stomach ailment and Ambien to treat insomnia. ... - Scripps Howard News Service,

Special Treatment For Rep. Kennedy?  May 5, 2006
In a statement, Kennedy said the attending physician for Congress had prescribed Phenergan to treat Kennedy's gastroenteritis, an inflammation of the stomach ... - CBS News

Report, but No Charges in Kennedy Crash  May 5, 2006
He said that he'd gone home Wednesday evening after work and took "the prescribed amount" of Phenergan, a prescription anti-nausea drug that can cause ... - Houston Chronicle,

Patrick Kennedy to undergo drug rehabilitation  May 5, 2006
In a statement, the congressman, who is the son of US Senator Edward Kennedy, said the attending physician for Congress had given him Phenergan to help him ... - CTV.ca,

Update 20: Rep. Patrick Kennedy to Enter Drug Rehab  May 5, 2006
Kennedy said that he'd gone home Wednesday evening after work and had taken "the prescribed amount" of Phenergan, a prescription anti-nausea drug that can ... - Forbes

Kennedy kin admits to a drug problem  May 7, 2006
...and strange behaviour on prescription drugs, telling how when he had returned home last Wednesday night, he took prescribed amounts of Phenergan and Ambien. ... - Deccan Herald,

Been there, heard that, didn't buy the excuse  May 5, 2006
Kenedy claims he took Phenergan, a prescribed anti-nausea medication, as well as Ambien, prescription sleeping pills. Phenergan ... - Capitol Hill Blue,

Rep. Kennedy to get rehab  May 6, 2006
Kennedy said he had gone home Wednesday evening after work and had taken "the prescribed amount" of Phenergan, a prescription anti-nausea drug that can cause ... - Baltimore Sun,

Rep. Kennedy entering treatment  May 6, 2006
Kennedy said he had taken "the prescribed amount" of Phenergan, a prescription anti-nausea drug that can cause drowsiness, and Ambien, a sleep medication, on ... - Buffalo News,

Kennedy 'Appeared Intoxicated' At Crash Scene  May 5, 2006
He says he took the anti-nausea medicine Phenergan and the sleeping pill Ambien, which made him so disoriented that he drove back to the Capitol in the middle ... - CBS4Boston,

Kennedy crashes car into DC traffic barrier  May 4, 2006
IN HIS STATEMENT, Kennedy said that last week he was treated for gastroenteritis by the attending congressional physician, who prescribed Phenergan, an anti ... - Providence Journal (subscription),

Kennedy Blames Accident on Medications  May 4, 2006
Later, however, he issued a longer statement saying the attending physician for Congress had prescribed Phenergan on Tuesday to treat Kennedy's gastroenteritis ... - Guardian Unlimited,

Rep. Kennedy says he took medication before crash  May 5, 2006
...no alcohol prior to the incident." Later, after a spate of news reports, he issued a longer statement saying a doctor had prescribed Phenergan on Tuesday to ... - Seattle Times,

Rep. Kennedy Cites Pill Use in Car Crash  May 5, 2006
...longer statement issued late Thursday, Kennedy, 38, said he had seen Congress' attending physician two days before and had been prescribed Phenergan to treat ... - Los Angeles Times,

Rep. Kennedy in 3 am crash near Capitol  May 5, 2006
Kennedy said the attending physician for Congress had prescribed Phenergan on Tuesday to treat gastroenteritis. He said he returned ... - Boston Globe,

Kennedy son dodges booze test, sez cop  May 5, 2006
Late last night, Kennedy put out a second statement saying the attending physician for Congress had prescribed Phenergan on Tuesday to treat his gastroenteritis ... - New York Daily News,

Kennedy says medications a factor in DC car accident  May 5, 2006
...issued late Thursday evening, Kennedy said he had seen the attending physician for Congress two days before and had been prescribed Phenergan to treat ... - Chicago Tribune,

Patrick Kennedy Crashes Car Into a Capitol Hill Barrier  May 4, 2006
...have been disoriented or drowsy at the time of the accident because he was taking two prescription drugs: Ambien, a sleeping pill, and Phenergan, an antinausea ... - New York Times,

Patrick Kennedy: Will he keep fundraising date in Chicago tonight  May 5, 2006
In a statement, Kennedy, DR.I., said the attending physician for Congress had prescribed Phenergan to treat Kennedy's gastroenteritis, an inflammation of the ... - Chicago Sun-Times,

Drugged Kennedy in crash  May 5, 2006
Later, however, Mr Kennedy issued a longer statement saying the attending physician for Congress had prescribed Phenergan to treat his gastroenteritis. ... - Australian,

Rep. Kennedy to Sign Up for Drug Treatment  May 6, 2006
D-Mass.), blamed his accident on the interaction of two prescription drugs he took Wednesday night — Ambien, for sleeplessness, and Phenergan, for nausea. ... - Los Angeles Times,

Rep. Kennedy says he'll seek drug treatment  May 6, 2006
In a statement to the media Thursday night, Kennedy said he had taken Phenergan for an upset stomach and Ambien to help him sleep. ... - Seattle Times,

Text: Statements From Rep. Patrick Kennedy  May 5, 2006
The Attending Physician prescribed Phenergan, an anti-nausea medication, which in addition to treating Gastroenteritis, I now know can cause drowsiness and ... - Washington Post,

Rep. Patrick Kennedy Blames Fashionable Drugs  May 4, 2006
According to Kennedy, the attending physician prescribed Phenergan, an anti-nausea medication, which in addition to treating gastroenteritis, “I now know [it ... - Yahoo! News

Sleep medicine said to provoke strange behavior  May 6, 2006
Dr. Bruce Cohen, psychiatrist-in-chief at McLean Hospital, Belmont, said that Ambien and Phenergan, an anti-nausea medication Kennedy said he was taking for ... - Boston Globe,

Kennedy says alcohol wasn't to blame in crash  May 5, 2006
He later issued a longer statement saying the attending physician for Congress had prescribed Phenergan on Tuesday to treat Kennedy's gastroenteritis, an ... - Los Angeles Daily News,

Patrick Kennedy crashes at Capitol  May 4, 2006
Later, however, Mr. Kennedy issued a longer statement saying the attending physician for Congress had prescribed Phenergan on Tuesday to treat the lawmaker's ... - Washington Times,

Rep. Kennedy blames crash on prescription  May 5, 2006
Later, however, he issued a longer statement saying a physician had prescribed Phenergan on Tuesday to treat Kennedy's gastroenteritis. ... - AZ Central.com,

Rep. Patrick Kennedy blames accident on prescription drugs  May 5, 2006
And in a statement, he admitted that his doctor "treated me for gastroenteritis (with) Phenergan, an anti-nausea medication, which .... ... - abc7.com,

Kennedy blames accident on medications  May 5, 2006
...late Thursday, his chief of staff handed out a statement saying he was on a prescribed combination of Ambien -- a sleep medication -- and Phenergan -- an anti ... - WBIR-TV,

Police Cite Kennedy for Traffic Violations  May 5, 2006
The attending physician for Congress had prescribed Phenergan to treat Kennedy‘s gastroenteritis, an inflammation of the stomach and intestines. ... - Herald News Daily,

Sleepy Kennedy crashes  May 6, 2006
In a statement Thursday, Kennedy, a Rhode Island Democrat, said the attending physician for Congress had prescribed Phenergan to treat Kennedy's gastroenteritis ... - Albuquerque Tribune,

Mainstream Media Blames Drug Ambien for Kennedy Crash  May 5, 2006
...wheel of his car. Kennedy also said he had taken the prescription nausea drug Phenergan. Instead of blaming Rep. Kennedy for his ... - The Conservative Voice,

Rep. Patrick Kennedy's Police Report Uncovered  May 5, 2006
Phenergan can also cause drowsiness, especially when combined with other drugs. A description of side effects of promethazine, the ... - Wizbang,

Reported by: Dr. Deanna Lites  May 5, 2006
7Healthcast Reporter Dr. Deanna Lites has more. The two prescription medications Patrick Kennedy says he took are Phenergan and Ambien. ... - WHDH-TV,

Can Sleep Medicine Be Responsible For Car Accidents?  May 5, 2006
...it. He's blaming medication. He says the anti-nausea drug Phenergan and the sleep aid Ambien caused him to be disoriented. Kennedy ... - WMDT,


Other information


Indication
For the treatment of allergic disorders, itching, nausea and vomiting

Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Mechanism Of Action
Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.

Drug Category
Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05

Brand Names/Synonyms
3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25

Dosage Forms
Tablets, suppositories, opthalmic drops, syrup

Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance

Interactions
-->Interactions for Promethazine:

Injection:

Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride.

Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered.


Syrup, Tablets and Suppositories:

CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose.

Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution.

Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories.



Chemical IUPAC Name
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

Chemical Formula
C17H20N2S

Half Life
16-19 hours

Drug Type
Approved Drug

# Accession No
APRD00601

CAS Registry Number
60-87-7

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