Peridex: profile and news

Action News Extra: Toothbrush Bacteria 16 May 2006
...see what worked. They soaked their brushes for 10 minutes in Listerine and in a prescription rinse called Peridex. They also tested ... - Pittsburgh Channel.com,

Improper Brush Storage Can Invite Bacteria Apr 27, 2006
Another used a prescription rinse called Peridex. ... The tests indicated that the Listerine and Peridex treatments killed 98 to 99 percent of the bacteria. ... - WBAL Channel.com,

Zila, Inc.'s Chief Executive Officer to Present at the 5th Annual ... May 12, 2006
...marketer of products to promote oral health and prevent oral disease, including ViziLite(R) Plus oral examination kits and Peridex(R) prescription periodontal ... - Genetic Engineering News,

: â€œSee Your Dentist â€“ It Can Save Your Lifeâ€?, Says Zila ... Apr 17, 2006
...to promote oral health and prevent oral disease, including ViziLiteÂ® Plus Oral Lesion Identification and marking System and PeridexÂ® prescription periodontal ... - NewsReleaseWire.com (press release)

Other information

Indication
For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures; For prevention of dental caries, oropharyngeal decontamination in critically ill patients; hand hygiene in health-care personnel; general skin cleanser; and catheter site preparation and care.

Pharmacology
Chlorhexidine, a topical antimicrobial agent, is used orally to treat mucositis, mouth infections, denture stomatitis, ulcerative stomatitis, acute necrotizing ulcerative gingivitis (ANUG), gingivitis, periodontitis and topically as an antiseptic and disinfectant.

Mechanism Of Action
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.

Drug Category
Anti-bacterial Agents; Anti-Infectives; ATC:A01AB03; ATC:B05CA02; ATC:D08AC02; ATC:D09AA12; ATC:R02AA05; ATC:S01AX09; ATC:S02AA09; ATC:S03AA04

Brand Names/Synonyms
Bioscrub; Brian Care; C6143; CHEMBANK1360; CHLORHEXIDINE BAS; Chlorhexidin; Chlorhexidin [Czech]; Chlorhexidine; Chlorhexidine Base; Chlorhexidine Gluconate; Chlorhexidine, Free Base; Chlorhexidinum [Inn-Latin]; Cida-Stat; Cloresidina [Dcit]; Clorhexidina [Inn-Spanish]; Decanoylacetaldehyde Sodium Sulfide; Dyna-Hex; E-Z Scrub; Exidine; Fimeil; HSDB 7196; Hexadol; Hibiclens; Hibidil; Hibiscrub; Hibisol; Hibispray; Hibistat; Hibitane; Microderm; Nolvasan; Oro-Clense; Peridex; Periochip; Periogard; Pharmaseal Scrub Care; Prevacare R; Rotersept; Savloclens; Savlon Babycare; Sodium Houttuyfonamide; Soretol; Steri-Stat; Sterido; Sterilon; Superspray; Tubulicid

Dosage Forms
Oral rince; Pellet, extended- release; PerioChip (in a biodegradable matrix of hydrolyzed gelatin [cross-linked with glutaraldehyde]) (glycerin) (purified water); CREAM; DRESSING; GEL; LOTION; OINTMEN; SPONGE

Absorption
absorption of chlorhexidine from the gastrointestinal tract is very poor

Interactions
Interactions for Chlorhexidine:

No information provided.

Chemical IUPAC Name
1-[amino-[6-[amino-[amino-(4-chlorophenyl)amino-methylidene]amino-methylidene]aminohexylimino]methyl]imino-N-(4-chlorophenyl)-methanediamine

Chemical Formula
C22H30Cl2N10

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00545

CAS Registry Number
55-56-1