Pepcid_AC: profile and news

Theft rings hit grocers May 9, 2006
...get out. When Durrant searched the vehicle, he found 30 cans of Similac worth $430 and 16 packages of Pepcid AC worth $325. The ... - Seattle Post Intelligencer

Why is Yao Ming so tall? Apr 26, 2006
...from Taiwan) did? Does Pepcid AC really help stave off Asian glow? How many times have we used the word тАЬAsianтА? so far? What do ... - Swarthmore College The Phoenix Online,

Other information

Indication
For treatment of Acid-reflux disorders (GERD тАУ gastroesophageal reflux disease); Peptic Ulcer Disease

Pharmacology
Famotidine, a histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Mechanism Of Action
Famotidine binds to an H₂-receptor located on the basolateral membrane of the parietal cell, blocking histamine effects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Drug Category
Anti-ulcer Agents; Histamine Antagonists; ATC:A02BA03

Brand Names/Synonyms
Amfamox; Antodine; Apo-Famotidine; Apogastine; Bestidine; Blocacid; Brolin; CHEMBANK1161; Cepal; Confobos; Cronol; Cuantin; Dibrit 40; Digervin; Dinul; Dipsin; Dispromil; Dispronil; Duovel; Durater; Evatin; FAMOTIDINE, 99%; Fadin; Fadine; Fadyn; Fagastine; Famo; Famocid; Famodar; Famodil; Famodin; Famodine; Famogard; Famonit; Famopsin; Famos; Famosan; Famotal; Famotep; Famotidina [Spanish]; Famotidine; Famotidine Preservative Free; Famotidine Preservative Free in Plastic Container; Famotidine [Usan:Ban:Inn:Jan]; Famotidinum [Latin]; Famotin; Famovane; Famowal; Famox; Famoxal; Famtac; Famulcer; Fanobel; Fanosin; Fanox; Farmotex; Ferotine; Fibonel; Fluxid; Fudone; Ganor; Gaster; Gastridan; Gastridin; Gastrion; Gastro; Gastro: Gastrodomina; Gastrodomina; Gastrofam; Gastropen; Gastrosidin; H2 Bloc; HSDB 3572; Hacip; Huberdina; Ifada; Ingastri; Invigan; Lecedil; Logos; MK 208; Mensoma; Midefam; Mosul; Motiax; Muclox; Mylanta; Mylanta Ar; Neocidine; Nevofam; Notidin; Novo-Famotidine; Nu-Famotidine; Nulceran; Nulcerin; Panalba; Pepcid; Pepcid Ac; Pepcid Preservative Free in Plastic Container; Pepcid Rpd; Pepcidin; Pepcidin Rapitab; Pepcidina; Pepcidine; Pepdif; Pepdine; Pepdul; Pepfamin; Peptan; Peptidin; Peptifam; Pepzan; Purifam; Quamatel; Quamtel; Renapepsa; Restadin; Rogasti; Rubacina; Sedanium-R; Sigafam; Supertidine; Tairal; Tamin; Tipodex; Topcid; Ulcatif; Ulceprax; Ulcetrax; Ulcofam; Ulfagel; Ulfam; Ulfamid; Ulfinol; Ulgarine; Vagostal; Weimok; Whitidin; Yamarin

Dosage Forms
SOLUTION; TABLET

Absorption
Absorption is incomplete, 40-45%

Interactions
-->Interactions for Famotidine:

No drug interactions have been identified. Studies with famotidine in man, in animal models, and in vitro have shown no significant interference with the disposition of compounds metabolized by the hepatic microsomal enzymes, e.g., cytochrome P450 system. Compounds tested in man include warfarin, theophylline, phenytoin, diazepam, aminopyrine and antipyrine. Indocyanine green as an index of hepatic drug extraction has been tested and no significant effects have been found.

Chemical IUPAC Name
4-[2-(amino-sulfamoylimino-methyl)ethylsulfanylmethyl]-2-guanidino-1,3-thiazole

Chemical Formula
C8H15N7O2S3

Half Life
2.5-3.5 hours

Drug Type
Approved Drug

# Accession No
APRD00296

CAS Registry Number
76824-35-6