Pepcid: profile and news

Heartburn blamed in cancer rise 16 May 2006
...people who have had severe gastric esophageal reflux disease for many years that they shouldn't keep popping Tums and over-the-counter Pepcid instead of seeing ... - Charlotte Observer,

J&J Takes it Easy May 12, 2006
...shoppers to "take it easy.". Participating brands include various Tylenol SKUs, Pepcid, Mylicon and Mylanta. One grand-prize winner ... - In-Store Marketing Institute (Subscription),

Theft rings hit grocers May 9, 2006
...get out. When Durrant searched the vehicle, he found 30 cans of Similac worth $430 and 16 packages of Pepcid AC worth $325. The ... - Seattle Post Intelligencer

Nasal spray dependence is a hard habit to break May 10, 2006
If you are not successful, ask your doctor whether Pepcid or Zantac would work in higher doses than you can purchase over the counter. ... - Daily Press,

Play it safe Apr 19, 2006
Over-the-counter drugs that used to be prescription drugs: Zantac, Pepcid, Prilosec, Claritin -- these were prescription medications three years ago. ... - Fort Worth Star Telegram,

Off-Label Drug Use May 2, 2006
That drug as well as cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), and sucralfate (Cara-fate) were (and in the case of all but Gastro-Gard ... - TheHorse.com,

Man faces charges of stealing medicine May 1, 2006
...$10,000 bail. Security officers stopped Morgan on Friday when he left the store with $677 worth of Tylenol and Pepcid, police said. - Cherry Hill Courier Post,

Police Report Apr 30, 2006
April 22. Police say the man tried to steal 21 bottles of Pepcid Complete, valued at $299.79, by hiding them in a purse. A robber ... - Miami Herald,

Hearts on fire Apr 26, 2006
...people who have had severe gastric esophageal reflux disease for many years that they shouldnтАЩt keep popping Tums and over-the-counter Pepcid instead of ... - Quad City Times,

Why is Yao Ming so tall? Apr 26, 2006
...from Taiwan) did? Does Pepcid AC really help stave off Asian glow? How many times have we used the word тАЬAsianтА? so far? What do ... - Swarthmore College The Phoenix Online,

Other information

Indication
For treatment of Acid-reflux disorders (GERD тАУ gastroesophageal reflux disease); Peptic Ulcer Disease

Pharmacology
Famotidine, a histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Mechanism Of Action
Famotidine binds to an H₂-receptor located on the basolateral membrane of the parietal cell, blocking histamine effects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Drug Category
Anti-ulcer Agents; Histamine Antagonists; ATC:A02BA03

Brand Names/Synonyms
Amfamox; Antodine; Apo-Famotidine; Apogastine; Bestidine; Blocacid; Brolin; CHEMBANK1161; Cepal; Confobos; Cronol; Cuantin; Dibrit 40; Digervin; Dinul; Dipsin; Dispromil; Dispronil; Duovel; Durater; Evatin; FAMOTIDINE, 99%; Fadin; Fadine; Fadyn; Fagastine; Famo; Famocid; Famodar; Famodil; Famodin; Famodine; Famogard; Famonit; Famopsin; Famos; Famosan; Famotal; Famotep; Famotidina [Spanish]; Famotidine; Famotidine Preservative Free; Famotidine Preservative Free in Plastic Container; Famotidine [Usan:Ban:Inn:Jan]; Famotidinum [Latin]; Famotin; Famovane; Famowal; Famox; Famoxal; Famtac; Famulcer; Fanobel; Fanosin; Fanox; Farmotex; Ferotine; Fibonel; Fluxid; Fudone; Ganor; Gaster; Gastridan; Gastridin; Gastrion; Gastro; Gastro: Gastrodomina; Gastrodomina; Gastrofam; Gastropen; Gastrosidin; H2 Bloc; HSDB 3572; Hacip; Huberdina; Ifada; Ingastri; Invigan; Lecedil; Logos; MK 208; Mensoma; Midefam; Mosul; Motiax; Muclox; Mylanta; Mylanta Ar; Neocidine; Nevofam; Notidin; Novo-Famotidine; Nu-Famotidine; Nulceran; Nulcerin; Panalba; Pepcid; Pepcid Ac; Pepcid Preservative Free in Plastic Container; Pepcid Rpd; Pepcidin; Pepcidin Rapitab; Pepcidina; Pepcidine; Pepdif; Pepdine; Pepdul; Pepfamin; Peptan; Peptidin; Peptifam; Pepzan; Purifam; Quamatel; Quamtel; Renapepsa; Restadin; Rogasti; Rubacina; Sedanium-R; Sigafam; Supertidine; Tairal; Tamin; Tipodex; Topcid; Ulcatif; Ulceprax; Ulcetrax; Ulcofam; Ulfagel; Ulfam; Ulfamid; Ulfinol; Ulgarine; Vagostal; Weimok; Whitidin; Yamarin

Dosage Forms
SOLUTION; TABLET

Absorption
Absorption is incomplete, 40-45%

Interactions
-->Interactions for Famotidine:

No drug interactions have been identified. Studies with famotidine in man, in animal models, and in vitro have shown no significant interference with the disposition of compounds metabolized by the hepatic microsomal enzymes, e.g., cytochrome P450 system. Compounds tested in man include warfarin, theophylline, phenytoin, diazepam, aminopyrine and antipyrine. Indocyanine green as an index of hepatic drug extraction has been tested and no significant effects have been found.

Chemical IUPAC Name
4-[2-(amino-sulfamoylimino-methyl)ethylsulfanylmethyl]-2-guanidino-1,3-thiazole

Chemical Formula
C8H15N7O2S3

Half Life
2.5-3.5 hours

Drug Type
Approved Drug

# Accession No
APRD00296

CAS Registry Number
76824-35-6