Penicillin_VK: profile and news

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Other information

Indication
For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms

Pharmacology
Penicillin V is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin V results from the inhibition of cell wall synthesis and is mediated through Penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Penicillins; ATC:J01CE02

Brand Names/Synonyms
Acipen V; Apopen; Beepen-Vk; Beromycin; Betapen-Vk; CCRIS 752; Calcipen; Compocillin V; Crystapen V; Distaquaine V; Eskacillian V; Eskacillin V; Fenacilin; Fenospen; Fenossimetilpenicillina [Dcit]; Fenoximetilpenicilina [Inn-Spanish]; Fenoxypen; HSDB 6314; Ledercillin Vk; Meropenin; Oracillin; Oratren; Ospen; Pen-Oral; Pen-V; Pen-Vee; Pen-Vee K; Penapar-Vk; Penicillin Phenoxymethyl; Penicillin V; Penicillin V Potassium; Penicillin V [Usan]; Penicillin Vk; Penicillin-Vk; Pfizerpen Vk; Phenocillin; Phenomycilline; Phenopenicillin; Phenoximethylpenicillinum; Phenoxymethyl Penicillin; Phenoxymethylenepenicillinic Acid; Phenoxymethylpenicillin Potassium; Phenoxymethylpenicillinic Acid; Phenoxymethylpenicillinic Acid Potassium Salt; Robicillin; Rocilin; Stabicillin; Uticillin Vk; V-Cil; V-Cillin; V-Cillin K; V-Cylina; V-Cyline; V-Tablopen; Vebecillin; Veetids; Veetids '125'; Veetids '250'; Veetids '500'

Dosage Forms
CAPSULE; CREAM; DISC (SUSTAINED-RELEASE); DROPS; DRUG PREMIX; LIQUID; LOTION; LOZENGE; OINTMENT; POWDER; POWDER FOR SOLUTION; SOLUTION; SPRAY; STICK; SUSPENSION; SYRUP (SUSTAINED-RELEASE); TABLET; TABLET (ENTERIC-COATED)

Absorption
25% of the dose given is absorbed,50-60% bioavailable

Interactions
Drug Interactions for Penicillin V:

No information provided.

Chemical IUPAC Name
3,3-dimethyl-6-oxo-7-(2-phenoxyacetyl)amino-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid

Chemical Formula
C16H18N2O5S

Half Life
30 to 40 minutes

Drug Type
Approved Drug

# Accession No
APRD00423

CAS Registry Number
87-08-1