|
![]() |
|
|
Peginterferon_alfa-2a: profile and news
Human Genome Sciences Presents Interim Results of Phase 2b Trial ... May 1, 2006 Chronic Hepatitis B Patients Still in Remission Two Years After ... Apr 28, 2006 New PEGASYS(R) Trial Shows Six Months of Treatment is Optimal for ... May 1, 2006 Roche's Innovative Oral Polymerase Inhibitor Shows Strong ... May 1, 2006 New Oral Polymerase Inhibitor Shows Promising Results in Chronic ... Apr 29, 2006 ΞΕÎ?Η ΔΗΜΟΣΙΕΥΣΗ-ΑÎ?ΑΚΟΙÎ?ΩΣΗ ΤΥΠΟΥ-PRN ... Apr 27, 2006 PEGASYS(R) ACCELERATE Trial Shows Six Months of Treatment Is ... Apr 29, 2006 The ticking time bomb of liver disease May 2, 2006 Roche Oral Drug Shows Promise in Hepatitis C May 5, 2006 Roche study shows hepatitis C patients need six months of ... May 3, 2006 COMUNICADO: Pacientes de Hepatitis B crónica permanecen en estado ... Apr 27, 2006 New Data Highlight Anti-HCV Activity of Investigational Oral ... Apr 26, 2006 Higher Dose COPEGUS(R) 400mg Tablets Approved in the Netherlands ... Apr 23, 2006 Other information Indication For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma Pharmacology Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R. Mechanism Of Action Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta. Drug Category Antiviral Agents; Immunomodulatory Agents; Antineoplastic Agents; interferons (08:18.20) Brand Names/Synonyms Interferon alpha-2 precursor;Interferon alpha-A;LeIF A; Pegasys (Hoffman-La Roche Inc) Dosage Forms SOLUTION Absorption Not Available Interactions Not Available Chemical IUPAC Name PEGylated human interferon alpha 2a Chemical Formula C860H1353N227O255S9 Half Life 50-140 hrs Drug Type Approved Drug # Accession No BIOD00043 CAS Registry Number 198153-51-4 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |