Paroxetine: profile and news
ABILIFY (Aripiprazole) Demonstrated Efficacy as Maintenance ... 16 May 2006
Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit ABILIFY elimination and cause increased blood levels. ... - PharmaLive.com (press release),
Treatment options are limited 16 May 2006
Published recently in the Journal of the American Medical Association, it found that antidepressants such as fluoxetine (Prozac) and paroxetine (Paxil) appear ... - Miami Herald,
Paroxetine: increased risk of suicidal behavior in young adults May 13, 2006
...of important changes to the Clinical Worsening and Suicide Risk subsection of the Warnings section in the labels for Paxil ( Paroxetine ) and Paxil CR ... - Xagena.it,
Warning: Antidepressant Paxil may raise suicide risk in young ... May 15, 2006
...and the FDA was accompanied by changes to the labelling of both Paxil and Paxil CR, a controlled-release version of the drug, also called paroxetine. ... - Canada.com,
Paxil/Paxil CR and Recent Meta-Analysis of Paroxetine Showed a ... May 12, 2006
A recent meta-analysis conducted of suicidal behavior and ideation in placebo-controlled clinical trials of paroxetine in adult patients with psychiatric ... - PharmaLive.com (press release),
Combined Psychotherapy and Pharmacotherapy for Mood and Anxiety ... May 15, 2006
...and cingulated cortices) provided by CBT and "bottom-up" effects (brainstem, insula, and subgenual cingulate) provided by pharmacotherapy with paroxetine. ... - Focus (subscription)
Paxil increases suicidal attempts in adults May 13, 2006
...is therefore important that all patients, especially young adults and those who are improving, receive careful monitoring during paroxetine therapy regardless ... - Food Consumer,
FDA: Paxil linked to increased suicide risk in young adults May 13, 2006
NYSE: GSK) have pointed out to health-care professionals changes in the warnings section for the prescribing information for Paxil, or paroxetine, and Paxil CR ... - Phoenix Business Journal,
GlaxoSmithKline, FDA Warn Paxil May Increase Suicide Risk In Young ... May 13, 2006
The warning from the company and FDA covered both Paxil or paroxetine hydrochloride tablets and oral suspension Paxil Controlled-Release tablets. ... - Trading Markets,
Implications of Research in Cognitive Neuroscience for ... May 15, 2006
...(2001). Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. ... - Focus (subscription)
Paxil Suicide Risk in Young Adults May 12, 2006
The new Paxil warning focuses on young adults aged 18-30. Paxil (paroxetine) is not approved for patients younger than 18. “It ... - WebMD
Patient Management Exercise FOR PSYCHOTHERAPY May 15, 2006
According to his self-reported history, he had trials of fluoxetine, paroxetine, lithium, divalproex, haloperidol, olanzapine, risperidone, clonazepam ... - Focus (subscription)
FDA Requires Makers of Paxil to Include Warning of Suicide Risks ... May 12, 2006
The new Paxil warning focuses on young adults aged 18-30. Paxil (paroxetine) is not approved for patients younger than 18. "It is ... - AXcess News,
Suicidal acts cited in adults on Glaxo's Paxil May 12, 2006
...and Drug Administration said it was reminding doctors to carefully monitor all patients while they are being treated with Paxil, known generically as paroxetine ... - Reuters
Paxil's maker, FDA warn of suicide risk May 13, 2006
The warning letter was accompanied by changes to the labeling of Paxil and Paxil CR, a controlled-release version of the drug, also called paroxetine. ... - Chicago Tribune,
US cites suicidal acts on Paxil May 13, 2006
...company added that it was "difficult to conclude a causal relationship" between the behaviour and the drug, which is known generically as paroxetine, and that ... - Reuters.uk,
Across the nation May 13, 2006
The letter was accompanied by changes to the labeling of both Paxil and Paxil CR, a controlled-release version of the drug, also called paroxetine. ... - Detroit Free Press,
Alternatives to Estrogen for Treatment of Hot Flashes May 2, 2006
...is a selective norepinephrine reuptake inhibitor (SNRI), the authors combine these results with those of trials of the SSRIs paroxetine and fluoxetine. ... - Journal of American Medical Association (subscription),
Tuesday, May 2, 2006, 4:54 pm May 2, 2006
Some of the more common drugs are Fluoxetine, Clonidine, Paroxetine and Gabapentin. This study is also in the Journal of the American Medical Association. - NBC5.com,
GlaxoSmithKline warns Paxil may raise suicide risk May 12, 2006
..."Results of this analysis showed a higher frequency of suicidal behavior in young adults treated with paroxetine compared with placebo," the FDA said in a ... - MarketWatch
Antidepressant linked to suicide risk in adults May 12, 2006
GSK says in the letter that it "continues to believe that the overall risk:benefit of paroxetine (Seroxat) in the treatment of adult patients" with depression ... - The Observer,
Paxil Linked to Increased Suicidal Behavior in Young Adults May 12, 2006
RESEARCH TRIANGLE PARK, NC, May 12 — GlaxoSmithKline has warned physicians that patients ages 18 to 30 treated with Paxil (paroxetine) have a small but ... - MedPage Today,
Paxil and the risk of birth defects May 10, 2006
Early results of new studies for Paxil (paroxetine) suggest that the drug increases the risk of birth defects, particularly heart defects, when women take it ... - Pregnancy and Baby,
Nation briefs May 12, 2006
...to doctors. The warning letter was accompanied by changes to the labeling of both Paxil and Paxil CR, also called paroxetine. An ... - Minneapolis Star Tribune (subscription),
SkyePharma PLC - Preliminary Results Announcement for the Year ... Apr 19, 2006
...of this formulation of Pulmicort(R). ORAL PRODUCTS Paxil CR(TM) Our improved formulation of GlaxoSmithKline's antidepressant Paxil(R) (paroxetine) remains a ... - PR Newswire (press release),
UPDATE:GlaxoSmithKline Warns Paxil May Raise Suicide Risk May 12, 2006
..."Results of this analysis showed a higher frequency of suicidal behavior in young adults treated with paroxetine compared with placebo," the FDA said in ... - Therapeutics Daily (subscription) (press release),
GlaxoSmithKline,FDA Notify Doctors Of Paxil Suicide Risk May 12, 2006
A recent meta-analysis conducted of suicidal behavior and ideation in placebo-controlled clinical trials of paroxetine in adult patients with psychiatric ... - Therapeutics Daily (subscription) (press release),
Antidepressants: Weighing the Decision Apr 20, 2006
The FDA did circulate a warning recently about the drug paroxetine but is still studying it and has not yet issued a final recommendation. ... - Standard-Speaker,
Nonhormonal Drugs Ease Hot Flashes, Study Says May 2, 2006
Among the drugs studied were the antidepressants Paxil (paroxetine), Effexor (venlafaxine), Prozac (fluoxetine) and Celexa (citalopram), the blood pressure ... - New York Times,
Some non-estrogen therapies may relieve hot flashes May 3, 2006
Reuters Health. This was observed for drugs such as such as paroxetine, venlafaxine, fluoxetine and citalopram. The antihypertensive ... - Reuters
Study lukewarm on non-hormone drugs against hot flashes May 3, 2006
The drugs include the anti-depressants Paxil (paroxetine), Effexor (venlafaxine), Prozac (fluoxetine) and Celexa (citalopram), the blood pressure drug Catapres ... - Chicago Tribune,
Study Finds Few Therapies Work Well on Hot Flashes May 3, 2006
The drugs include the antidepressants Paxil (paroxetine), Effexor (venlafaxine), Prozac (fluoxetine) and Celexa (citalopram), the blood pressure drug Catapres ... - New York Times,
Non-Hormone Therapies Offer Some Hot-Flash Relief May 2, 2006
Nelson said. The SSRI type of antidepressant, such as paroxetine (Paxil), also reduced hot flashes by about one a day. And gabapentin ... - Forbes
Hot flashes, cold facts May 8, 2006
Published last week in the Journal of the American Medical Assn., it found that antidepressants such as fluoxetine (Prozac) and paroxetine (Paxil) appear to ... - Los Angeles Times,
Study favors hormones for hot flashes May 7, 2006
Including the antidepressants Paxil (paroxetine), Effexor (venlafaxine), Prozac (fluoxetine) and Celexa (citalopram), the blood pressure drug Catapres ... - Indianapolis Star,
Nonhormonal Therapies May Offer Relief From Hot Flashes, With ... May 3, 2006
...efficacy of selective serotonin reuptake inhibitors (SSRIs) or serotonin noradrenergic reuptake inhibitors (SNRIs) [such as paroxetine, venlafaxine, fluoxetine ... - DG News
Many Hot Flash Remedies a Flash in the Pan May 2, 2006
The meta-analysis showed that in seven trials the selective serotonin reuptake inhibitors Prozac (fluoxetine), Paxil (paroxetine), and Celexa (citalopram) and ... - MedPage Today,
Lundbeck files application for approval of Cipralex for the ... Apr 28, 2006
...blind placebo controlled study 458 OCD patients were randomised to either escitalopram at one of the two doses (10mg or 20mg), or 40mg paroxetine or placebo. ... - PharmaLive.com (press release),
Popular antidepressants may affect fetus Apr 20, 2006
The study included SSRIs such as fluoxetine (Prozac) Paroxetine (Paxil) and Sertraline (Zoloft), but the sample size was not large enough to estimate risks for ... - News-Medical.net,
Other information
Indication
For the treatment of depression, depression accompanied by anxiety, obsessive compulsive disorder and panic attacks
Pharmacology
Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs. It is used to treat depression resistant to other antidepressants, depression complicated by anxiety, panic disorder, social and general anxiety disorder, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder, premature ejaculation, and hot flashes of menopause in women with breast cancer.
Mechanism Of Action
Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, therefore it prolongs its activity at synaptic receptor sites and potentiates 5-HT in the CNS; paroxetine is more potent than both sertraline and fluoxetine in its ability to inhibit 5-HT reuptake. Compared to the tricyclic antidepressants, SSRIs have dramatically decreased binding to histamine, acetylcholine, and norepinephrine receptors.
Drug Category
Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB05
Brand Names/Synonyms
Aropax; FG 7051; Paroxetina [Inn-Spanish]; Paroxetine; Paroxetine Hcl; Paroxetine [Usan:Ban:Inn]; Paroxetinum [Inn-Latin]; Paxil; Paxil Cr; Pexeva; Seroxat
Dosage Forms
Tablet
Absorption
completely absorbed after oral dosing
Interactions