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Papaverine: profile and news
Love’sa step ahead of MS Apr 24, 2006 Vanilla's Value Apr 25, 2006 Other information Indication Impotence Pharmacology Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries. Mechanism Of Action Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy. Drug Category Vasodilator Agents; Vasodilator Agents; ATC:A03AD01; ATC:G04BE02 Brand Names/Synonyms Alapav; Artegodan; Cardiospan; Cardoverina; Cepaverin; Cerebid; Cerespan; Chlorhydrate de Papaverine; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; HSDB 3147; Myobid; Optenyl; PAPAVERINE; Pameion; Pamelon; Panergon; Pap H; Papacon; Papalease; Papanerin; Papanerin-Hcl; Papanerine; Papavarine Chlorhydrate; Papaverin; Papaverine Chlorohydrate; Papaverine Hcl; Papaverine Hydrochloride; Papaverine Monohydrochloride; Papaverine, Hydrochloride; Papaverinium Chloride; Papaversan; Papital T.R.; Paptial T.R.; Pavabid; Pavabid Hp; Pavacap; Pavacels; Pavacen; Pavacot; Pavadel; Pavagen; Pavakey; Pavarine; Pavased; Pavatest; Pavatine; Pavatym; Paverolan; Paveron; Pavnell; Qua Bid; Ro-Papav; Robaxapap; Spasmo-Nit; Therapav; Vasal; Vaso-Pav; Vasospan Dosage Forms LIQUID Absorption Not Available Interactions -->Interactions for Papaverine: No information provided. |
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