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Other information

Indication
Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness.

Pharmacology
Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Methscopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Methscopolamine also may work directly on the vomiting center. Methscopolamine must be taken before the onset of motion sickness to be effective.

Mechanism Of Action
Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Drug Category
Antispasmodics; Anticholinergic Agents; ATC:A03BB03; ATC:S01FA03

Brand Names/Synonyms
Ampyrox; Blocan; CHEMBANK1009; CHEMBANK3225; Diopal; Epoxymethamine Bromide; Epoxytropine Tropate Methylbromide; Holopon; Hyoscine Methobromide; Hyoscine Methylbromide; Lescopine Bromide; Mescopil; Methoscopylamine Bromide; Methscopolamine; Methscopolamine Bromide; Methscopolamine Methylbromide; Methylscopolamine Bromide; Methylscopolamine Hydrobromide; N-Methylhyoscine Bromide; N-Methylscopolamine Methylsulfate; N-Methylscopolammonium Bromide; Neo-Avagal; Nutrop; Pamine; Pamine Bromide; Paraspan; Proscomide; Restropin; SCOPOLAMMONIUM, N-METHYLBROMIDE; Scopolamin Methylbromide; Scopolamine Methobromide; Scopolamine Methylbromide; Scopolammonium, N-Methylbromide; Transderm Scop

Dosage Forms
Tablet (2.5mg, 5mg)

Absorption
Poorly and unreliably absorbed. Total absorption is 10-25%.

Interactions
Interactions for Methscopolamine:
Methscopolamine may interact with antidepressants (tricyclic type), MAO inhibitors (e.g., phenelzine, linezolid, tranylcypromine, isocarboxazid, selegiline, furazolidone), quinidine, amantadine, antihistamines (e.g., diphenhydramine), other anticholinergics, potassium chloride supplements, antacids, absorbent-type anti-diarrhea medicines (e.g., kaolin-pectin), phenothiazines (e.g., chlorpromazine, promethazine).

Chemical IUPAC Name
Not Available

Chemical Formula
C18H24NO4

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00314

CAS Registry Number
155-41-9