Oxytetracycline: profile and news

Club Feet Apr 24, 2006
...the offspring. More recently, reports Trotter, the use of oxytetracycline has been advocated for some of these deformities. We now ... - TheHorse.com,

Other information

Indication
Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.

Pharmacology
Oxytetracycline, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Oxytetracycline is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.

Mechanism Of Action
Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

Drug Category
Anti-bacterial Agents; Tetracyclines; ATC:D06AA03; ATC:G01AA07; ATC:J01AA06; ATC:S01AA04

Brand Names/Synonyms
Oxytetracycline; Oxytetracycline Anhydrous; Oxytetracycline Hcl; Terramycin

Dosage Forms
DRUG PREMIX

Absorption
Not Available

Interactions
Interactions for Oxytetracycline:

No Information Provided

Chemical IUPAC Name
2-(amino-hydroxy-methylidene)-4-dimethylamino-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione

Chemical Formula
C22H24N2O9

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00019

CAS Registry Number
79-57-2