Oxycodone: profile and news
With John Merla, it's one 16 May 2006
To suggest that a patient already receiving huge doses of morphine, OxyContin, oxycodone, Xanax or the like to manage pain will be threatened by a few tokes of ... - Woodbridge Sentinel,
WayPoint Biomedical Launches New Range of Clinical Drugs of Abuse ... 16 May 2006
...confirmation. A second drug test, the Multi-Drug-11 includes all the above mentioned drugs, along with Oxycodone and Propoxyphene. ... - MacReport (press release),
NW Arkansas crime report 16 May 2006
Michael Smith, 44, was arrested on a charge of contempt of court. Rodney Williams, 45, was arrested on a charge of possession of Oxycodone. ... - Arkansas Democrat-Gazette (subscription),
Oxycodone factor in Ticat's death: Coroner May 10, 2006
HAMILTON -- Hamilton Tiger-Cats lineman Travis Claridge was "intoxicated" with the painkiller oxycodone when he died of pneumonia in February, according to the ... - Toronto Sun,
Oxycodone, Hydrocodone Abuse May 3, 2006
Forty percent of the 119,000 mentions of narcotic pain medications in emergency rooms involved either oxycodone or hydrocodone in 2002, according to a new ... - About - News & Issues,
ORADUR(TM) Technology Milestone: Remoxy(TM) (ORADUR-Based ... May 5, 2006
...initiated for Remoxy(TM), an abuse-resistant pain medicine under development based on DURECT's patented ORADUR(TM) technology incorporating the opioid oxycodone ... - Yahoo! News (press release)
Luyao sentenced to 50 years in oxycodone death Apr 28, 2006
...trafficking charges. She was acquitted by the jury of five other counts of manslaughter and another count of trafficking in oxycodone. The ... - Stuart News (subscription),
Investigators Present Final Results of Three Groundbreaking Trials ... May 4, 2006
AVINZA showed better around the clock control of chronic pain and improved sleep in a large randomized study comparing AVINZA given once daily to oxycodone CR(1 ... - Genetic Engineering News,
Sting operation leads to drug bust in South Windham May 12, 2006
...arrested two alleged drug dealers in South Windham on Monday night in a sting operation that netted large quantities of morphine and Oxycodone, both narcotic ... - KeepMEcurrent.com,
May 9, 2006 Tazewell County grand jury indictments May 14, 2006
Possession of oxycodone, a schedule II controlled substance (two counts); possession of alprazolam, a schedule IV controlled substance (misdemeanor) (two counts ... - Richlands News-Press & Clinch Valley News,
Former CFLer's death an accident May 9, 2006
Hamilton Tiger-Cats lineman Travis Claridge was intoxicated with the painkiller oxycodone when he died of pneumonia on Feb. 28 in Las Vegas. ... - CBC News,
Jailed PSL man, 75, tells police he tried to sell his oxycodone to ... May 11, 2006
Fort Pierce police arrested an elderly man Monday afternoon in the parking lot of the Goodwill store on US 1 on charges of trafficking oxycodone and delivering ... - Fort Pierce Tribune (subscription),
Las Vegas Prescription Drug Abuse Growing Problem May 3, 2006
In fact, one local pharmacy alone fills the third highest amount of prescriptions for the highly addictive Oxycodone in the country. ... - KLAS-TV,
Big drug bust in core has police concerned May 13, 2006
...crime. - A potent painkiller, it contains oxycodone, a narcotic similar to morphine widely used to treat cancer patients. - Known ... - London Free Press,
Marshall saddened by loss of Tiger-Cat May 10, 2006
According to a Las Vegas coroner's report released this week, Hamilton defensive lineman Travis Claridge was "intoxicated" with oxycodone, or OxyContin, when ... - Toronto Star,
Watson Pharmaceuticals Q1 EPS Declines On Lower Brand Product ... May 9, 2006
...sales rose 10% to $321.4 million from $293.2 million in the last-year quarter, on the launch of an authorized generic version of oxycodone extended-release ... - Trading Markets,
Ricky may face drug testing as an Argo May 9, 2006
PNEUMONIA CLAIMED TICAT: Tiger-Cats lineman Travis Claridge was "intoxicated" with the painkiller oxycodone when he died of pneumonia in February, according to ... - Ottawa Sun,
Death of pro football lineman in Las Vegas ruled accidental May 9, 2006
...pneumonia killed professional football offensive lineman Travis Claridge in February, but he also had an intoxicating level of the painkiller oxycodone in his ... - Las Vegas Sun,
Around South Florida May 13, 2006
...stuck manatee. A Port St. Lucie is accused of selling his prescribed oxycodone to buy gas for his mobile home. Police said Ernest ... - Miami Herald,
Police and Fire May 13, 2006
During the arrest process, police also discovered a quantity of oxycodone hydrochloride leading to a second charge for possession of schedule II narcotics. ... - Sault Ste. Marie Evening News,
Heroin access easy, death toll scary May 14, 2006
Whereas an 80-milligram oxycodone pill costs $40 on the street, you can buy a baggie of heroin for $10. "I see a lot of students with money stick to pills. ... - Connecticut Post,
Drug dealer gets prison May 14, 2006
...half to three-year term in state prison after Londergan pleaded guilty to possession of cocaine with intent to distribute, possession of oxycodone with intent ... - Berkshire Eagle,
Men involved in gambling operation indicted May 3, 2006
...of unlawfully possessing a controlled substance classified as marijuana, one count of unlawfully possessing a controlled substance, to wit, oxycodone, and one ... - Eyewitness News,
Watson Pharmaceuticals Reports First Quarter 2006 Results May 9, 2006
...$321.4 million, compared to $293.2 million in the prior year period, due to the Company's launch of an authorized generic version of oxycodone extended-release ... - Yahoo! News (press release)
Second Fishers CVS robbed of drugs; suspect sought May 3, 2006
...pm. The man entered the store, went straight to the pharmacy and handed an employee a note demanding Oxycodone and Percocet. The ... - Noblesville Daily Times,
Oxymorphone Studies Presented at American Pain Society Annual ... May 4, 2006
...patients with chronic, moderate-to-severe low back pain whose pain was inadequately controlled on their previous opioid therapy (oxycodone ER, fentanyl patch ... - DG News
Waldo County grand jury indicts 25 Apr 28, 2006
...release. The indictment alleges Anderson possessed Oxycodone, a Schedule W drug, April 3, while in custody for previous crimes. ... - VillageSoup Belfast,
Drug registry needed, everyone agrees May 7, 2006
...nervous system. Her doctor prescribed morphine to control the pain, oxycodone and dilaudid. It was the only therapy recommended. A ... - ChronicleHerald.ca,
Man Pleads Guilty to Manslaughter May 2, 2006
Cruickshank pled guilty yesterday to injecting Latimer with oxycodone. ... Forensics found high levels of oxycodone and alcohol in Latimers blood. ... - CD98.9,
Plea agreement set in Tiverton drug case Apr 28, 2006
Cabral also found several Oxycodone capsules in a briefcase in Sousa's car. In a subsequent search of a house at 38 Knotty Pine ... - Providence Journal (subscription),
Former nursing home employees face trail Apr 22, 2006
The second of two former employees of a Somerset nursing home accused of stealing Oxycodone, a potent prescription painkiller, from a patient's family charges ... - Daily American Online (subscription),
Hancock man charged in pharmacy robbery Apr 20, 2006
The pills were Oxycodone, OxyContin, Percocet and Roxicet, according to charging documents. A search and seizure warrant served ... - Hagerstown Morning Herald,
Dead football player had used painkiller May 9, 2006
The painkiller was oxycodone, an addictive substance that can depress the respiratory system while producing euphoria similar to narcotics like morphine and ... - San Jose Mercury News,
Tiger Cat player's death an accident, Las Vegas coroner rules May 9, 2006
...was pneumonia. But the coroner says Claridge was intoxicated with the painkiller oxycodone and had an enlarged heart. The Ticats ... - Globe and Mail,
Teva dives as Ivax buy leads to $1 billion loss May 10, 2006
These include Oxycodone, a strong painkiller for chronic pain; Gabapentin, an anticonvulsant for people with epilepsy; and Propofol, an injectable short-term ... - Ha'aretz,
Father of dead boy tells of slitting his own wrists Apr 26, 2006
CARTHAGE - A Plymouth man accused of giving his son a fatal overdose of Oxycodone testified Tuesday that after he realized his son was dead he slit his own ... - Peoria Journal Star,
Ducks' Lupul gets 4 goals May 10, 2006
Former NFL offensive lineman Travis Claridge had an intoxicating level of the painkiller oxycodone in his system and an enlarged heart when he died ... - The Argus,
Death of pro football lineman in Las Vegas ruled accidental May 9, 2006
But the six-foot-five, 300-pound Claridge also had an enlarged heart -- and an intoxicating level of the painkiller oxycodone (Ox ee COH' doan) in his system. ... - KESQ,
Sports Briefs column May 10, 2006
But the coroner says Claridge was intoxicated with the painkiller oxycodone and had an enlarged heart. LOUISVILLE, Ky. -- Hulking Jim Thome. ... - Winnipeg Sun,
Death Of Former USC Football Player Ruled Accidental May 9, 2006
But Claridge, 5 feet 5 inches tall, 300 pounds, also had an enlarged heart and an intoxicating level of the painkiller oxycodone in his system. ... - NBC4.TV,
Walker Deal Done? May 10, 2006
Lineman's death ruled accidental: Former NFL lineman Travis Claridge had an intoxicating level of a painkiller, oxycodone, in his system and an enlarged heart ... - Hartford Courant,
Nearly Two Million Drug-Related Visits to US ERs in 2004: Report May 10, 2006
The most frequently used prescription pain killers were: hydrocodone products (42,491 ER visits); oxycodone products (36,559 visits); and methadone (31,874 ... - KLAS-TV,
Gov't Study Reveals 2 Million Drug Related ER Visits in One Year May 12, 2006
Hydrocodone products, involved in 42,491 emergency room visits, oxycodone products, in 36,559 emergency department visits, and methadone in 31,874 visits, were ... - The Conservative Voice,
Police chase ends in drug arrest May 12, 2006
The officers searched the room and found a bag of Oxycodone and Lortab, and seized an undisclosed sum of cash from the Honda, police said. ... - Online Athens (subscription),
Weekly News | Christian Views May 11, 2006
...other amphetamines, Adderall is classified as a Schedule II controlled substance, putting it in the same legal classification as cocaine, oxycodone and opium. ... - World Magazine
Man arrested for having sex with adopted son May 11, 2006
..."Also involving the adopted son’s friends, shots of them having sex. He also gave them drugs to do it. Ecstasy, oxycodone to alcohol," said Molloy. ... - WBBH,
Sports Briefs May 10, 2006
Travis Claridge, a lineman with the CFL's Hamilton Tiger-Cats, had an intoxicating level of the painkiller oxycodone in his system and an enlarged heart ... - Winston-Salem Journal,
Heroin suspects walk off May 1, 2006
...remove his shirt and pants. An oxycodone pill fell out of his underwear, which police also asked him to remove. A needle cap was ... - MetroWest Daily News,
Other information
Indication
For the treatment of diarrhoea, pulmonary oedema; For the relief of moderate to moderately severe pain
Pharmacology
Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism Of Action
Oxycodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Oxycodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Category
Narcotics; Antitussives; Analgesics, Opioid; Opiate Agonists; ATC:N02AA05
Brand Names/Synonyms
Codeinone, Dihydrohydroxy-; Combunox; Dea No. 9143; Dihydrohydroxycodeinone; Dihydrohydroxycondeinone; Dihydrone; Dihydroxycodeinone; Dinarkon; Diphydrone; ENDOCET; ENDODAN; Endone; Eubine; Eubine [France]; Eucodal; Eucodalum; Eukodal; Eutagen; HSDB 3142; Ossicodone [Dcit]; Oxanest; Oxicodona [Inn-Spanish]; Oxicon; Oxicone; Oxikon; Oxycet; Oxycodeinone; Oxycodon; Oxycodone; Oxycodone Hcl; Oxycodone Hydrochloride; Oxycodone [Usan:Ban:Inn]; Oxycodonum [Inn-Latin]; Oxycon; Oxycontin; PERCOCET; Pancodine; Percobarb; Percocet; Percodan; Roxicet; Roxicodone; Roxilox; Supendol [Canada]; Tecodin; Tekodin; Thecodine; Thekodin; Tylox
Dosage Forms
Tablet; Suppository
Absorption
well absorbed from OxyContin® tablets with an oral bioavailability of 60% to 87%
Interactions
Interactions for Oxycodone:
The CNS depressant effects of oxycodone hydrochloride may be additive with that of other CNS depressants..
Chemical IUPAC Name
4, 5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Chemical Formula
C18H21NO4
Half Life
4.5 hours
Drug Type
Approved Drug
# Accession No
APRD00387
CAS Registry Number
76-42-6