OxyContin: profile and news
Bath Man Sentenced For Pharmacy Robbery 16 May 2006
He demanded Oxycontin from the pharmacist, but made off with two bottles of Ritalin instead after becoming impatient and jumping over the counter when the ... - WLBZ-TV,
Three More Iron County Residents Arrested On Drug Charges 16 May 2006
Police say several other arrests are pending as the investigation continues. The drugs involved are primarily oxycontin and morphine. ... - WLUC-TV,
1 in 5 teens has abused painkillers 16 May 2006
...for a Drug-Free America study, released Monday, shows that one in five teenagers has tried prescription painkillers such as Vicodin and OxyContin to get high. ... - NorthJersey.com,
Police blotter: About $700 in pills confiscated 16 May 2006
...in Guyandotte. Deputies confiscated nine Lortab and 16 OxyContin pills, along with $739 cash. The pills were worth $690. ARREST: James ... - Huntington Herald Dispatch,
Tuesday, May 16, 2006, 3:12 pm 16 May 2006
Nineteen percent, nearly one in five, have used prescription pain medicine to get high, drugs like Vicodin, Oxycontin or Ritalin. ... - NBC5.com,
Teens find a high in the medicine cabinet 16 May 2006
...the Partnership for a Drug-Free America shows that 4.5 million teens -- about 1 in 5 -- have tried prescription painkillers like Vicodin and OxyContin and that ... - DetNews.com,
Man Arrested for Selling Prescription Drugs 16 May 2006
...distribution. His arrest, which took place at a Sunset truck-stop, yielded prescription pills, including Oxycontin, Lortab and Methadone. ... - KLFY,
Study: One in Five Teens Abuses Prescription Drugs 16 May 2006
...inhibitions.". Drugs like vicodin or oxycontin. A national study shows nearly one in five teens report using prescription drugs to get high. ... - WMTV,
Organization Reports Teens Abusing Prescription Drugs 16 May 2006
His mom started a local effort to fight teen drug abuse. But she didn't know her own son was using Vicodin, Oxycontin and a number of other prescription drugs. ... - NBC4.TV,
With John Merla, it's one 16 May 2006
To suggest that a patient already receiving huge doses of morphine, OxyContin, oxycodone, Xanax or the like to manage pain will be threatened by a few tokes of ... - Woodbridge Sentinel,
One In Five Teens Use Prescription Drugs To Get High 16 May 2006
America. It shows one in five teens have tried to use prescription drugs to get high, including vicodin and oxycontin. Teenagers ... - WKRC 12,
Suspect sought in Oxycontin robbery May 15, 2006
TEMPE - Police were still searching Monday for a man who put a plastic bag over his head to rob Walgreens for the prescription pain drug Oxycontin. ... - AZ Central.com,
Police seize Oxycontin pills May 12, 2006
London police have seized more than $8,000 in Oxycontin pain pills — known on the street as "hillbilly heroin" — after raiding a downtown business Thursday ... - London Free Press,
City worker charged in OxyContin hold-ups May 10, 2006
By THOMYA HOGAN. Clarksville Police Tuesday arrested the man they believe to be behind a string of armed robberies for OxyContin at local pharmacies. ... - Clarksville Leaf Chronicle,
Thefts of Power Drug Oxycontin on the Increase May 10, 2006
Patrice Walsh (Rochester, NY) - Pharmacies along the East Coast are on alert after a rash of robberies of powerful narcotics like oxycontin. ... - 13WHAM-TV,
Arrest coming in OxyContin robberies May 9, 2006
Clarksville police say they have an arrest coming today in the recent string of OxyContin armed robberies. On April 15, a man carrying ... - Clarksville Leaf Chronicle,
'Top level' OxyContin dealer sentenced to six years May 10, 2006
BOSTON — A man who prosecutors said sold much of the OxyContin bought by addicts on Gloucester's streets was sentenced yesterday to six years in prison. ... - Salem News,
Woman with gun robs Walgreens for Oxycontin May 4, 2006
A woman with a handgun tucked into the waist of her pants walked into a Green Bay Walgreens Wednesday night and demanded all the OxyContin in the store's ... - Green Bay Press Gazette,
Police Arrest Two for Walgreen's OxyContin Robbery May 4, 2006
9 pm a young woman, about 20 years old, with a semi-automatic handgun gave the pharmacist a handwritten note demanding the prescription painkiller OxyContin. ... - WBAY,
Two arrested in OxyContin theft May 5, 2006
Less than two hours after a woman with a handgun robbed a Green Bay Walgreens Wednesday night of OxyContin, police made two arrests in the case. ... - Green Bay Press Gazette,
Confronted by caller, Limbaugh denied any similarity between his ... May 8, 2006
Summary: Rush Limbaugh denied any comparison between his own prescription drug problems and those of Rep. Patrick Kennedy, who says ... - Media Matters for America,
NJ brothers get prison terms in OxyContin distribution ring Apr 25, 2006
NEWARK, NJ --Two brothers were sentenced to prison Tuesday for operating an illegal drug ring that sent the painkiller OxyContin to Connecticut and the Boston ... - Boston Globe,
Brothers sentenced to prison terms for OxyContin ring Apr 25, 2006
Two brothers described by authorities as key figures in a drug ring that funneled large amounts of OxyContin from Newark to college campuses in New England ... - Newark Star Ledger,
SANDWICH DOCTOR INDICTED ON CHARGES HE ALLEGEDLY PRESCRIBED ... Apr 25, 2006
The indictments allege that Brown prescribed OxyContin, Roxicodone and other Oxycodone-based medications in bad faith and for no legitimate medical purpose. ... - Massachusetts Attorney General,
Cape Doctor Indicted In Oxycontin Scheme Apr 26, 2006
Doctor Michael Brown of Mashpee is accused of prescribing the painkiller Oxycontin for no legitimate medical reasons. Prosecutors ... - CBS4Boston,
OxyContin charges dropped against Lansing doctor Apr 18, 2006
...(Grand Rapids, April 18, 2006, 5:02 pm) -- The US District Court has dismissed a complaint against a Lansing doctor accused of selling OxyContin without a ... - WOOD-TV,
Sheriff: Man used false ID to get OxyContin Apr 20, 2006
...that Solomon assumed the identities of two of his employees and eight current and former clients to obtain more than 1,100 grams of OxyContin, a strong ... - St. Petersburg Times,
OxyContin robber hits Fishers CVS Apr 17, 2006
Witnesses told police that the man entered the store and went to the pharmacy, where he handed an employee a note demanding OxyContin and methadone. ... - Noblesville Ledger,
Brothers Get Prison Terms In OxyContin Ring Apr 26, 2006
NJ -- A federal judge in Newark sentenced two brothers to prison Tuesday for operating an illegal drug ring that sent the painkiller OxyContin to Connecticut ... - Turn to 10.com,
Brothers get prison terms in OxyContin distribution ring Apr 25, 2006
...illegal drug ring. Authorities say the ring sent the painkiller OxyContin to Connecticut and the Boston area. Michael and Nicholas ... - WTNH,
Oxycontin Dealers Sentenced Apr 26, 2006
...next month. The group bought oxycontin pills in New Jersey, and brought them to Connecticut and sold them to local drug dealers. - WFSB,
Police shoot, kill suspect trying to steal OxyContin Apr 23, 2006
Cambridge City -- Police officers shot and killed a man who pointed a gun at them when they interrupted his attempt to steal drugs from a pharmacy, police said ... - Indianapolis Star,
Ionia doctor may lose license over Oxycontin fraud Apr 25, 2006
IONIA - Ionia physician John F. Hildebrandt, who late last week pleaded guilty to one count of mail fraud relating to an Oxycontin scheme involving several ... - Sentinel-Standard,
Limiting the access to OxyContin Apr 27, 2006
But what we do know already stands as disturbing evidence of the daring and dependence by those apparently addicted to the prescription drug OxyContin. ... - Palladium-Item,
Lynn man indicted on OxyContin trafficking charge Apr 20, 2006
PEABODY — A Lynn man who allegedly tossed $32,000 worth of OxyContin out a car window as Peabody police pulled him over last January was indicted on a ... - Salem News,
Acclaimed photographer teams with former OxyContin addict to film ... Apr 29, 2006
...to anything. Eddie Buchanan, a 28-year-old Glace Bay man whose life was destroyed by an OxyContin addiction, is that man. Clean ... - ChronicleHerald.ca,
Police say teen tried to sell OxyContin Apr 22, 2006
WEST MILFORD -- A 15-year-old Macopin Middle School student has been charged with possession of drugs after school officials found OxyContin tablets in his ... - NorthJersey.com,
Big drug bust in core has police concerned May 13, 2006
...raided the Cup of Coffee variety store at Dundas and Richmond streets Thursday, arresting the clerk and finding more than 300 tablets of OxyContin, a highly ... - London Free Press,
FDA To Pressure Drug Companies On RFID May 15, 2006
...a few high-profile RFID pilot projects, including putting RFID tags on bottles of Viagra and using the technology to track bottles of the painkiller OxyContin. ... - InformationWeek,
Doctor leads way in fight over pain relief May 13, 2006
...known as the DEA, and Justice Department – alarmed by the seemingly widespread diversion of opium-based prescription drugs such as OxyContin and Dilaudid to ... - Fort Wayne Journal Gazette,
Brothers get prison terms in OxyContin distribution ring Apr 25, 2006
NEWARK, NJ (AP) _ Two brothers were sentenced to prison Tuesday for operating an illegal drug ring that sent the painkiller OxyContin to Connecticut and the ... - Newsday,
Sane makes Oxy bust May 10, 2006
According to a SANE news release, officers arrested a 44-year-old Alanson man on April 28 on charges of delivery of OxyContin, conspiracy to deliver OxyContin ... - Petoskey News-Review,
SANE reports area arrests in recent weeks May 10, 2006
He was charged in connection with delivery of OxyContin and conspiracy to deliver OxyContin. He was lodged in the Emmet County Jail. ... - Cheboygan Daily Tribune (subscription),
Marshall saddened by loss of Tiger-Cat May 10, 2006
...to a Las Vegas coroner's report released this week, Hamilton defensive lineman Travis Claridge was "intoxicated" with oxycodone, or OxyContin, when he died of ... - Toronto Star,
Though Police Killed Man, Other Person Charged In Death May 11, 2006
Hunt waited in the car while Potter went inside and demanded the prescription painkiller OxyContin. ... OxyContin is a painkiller that can be highly addictive. ... - INDYchannel.com,
Other information
Indication
For the treatment of diarrhoea, pulmonary oedema; For the relief of moderate to moderately severe pain
Pharmacology
Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism Of Action
Oxycodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Oxycodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Category
Narcotics; Antitussives; Analgesics, Opioid; Opiate Agonists; ATC:N02AA05
Brand Names/Synonyms
Codeinone, Dihydrohydroxy-; Combunox; Dea No. 9143; Dihydrohydroxycodeinone; Dihydrohydroxycondeinone; Dihydrone; Dihydroxycodeinone; Dinarkon; Diphydrone; ENDOCET; ENDODAN; Endone; Eubine; Eubine [France]; Eucodal; Eucodalum; Eukodal; Eutagen; HSDB 3142; Ossicodone [Dcit]; Oxanest; Oxicodona [Inn-Spanish]; Oxicon; Oxicone; Oxikon; Oxycet; Oxycodeinone; Oxycodon; Oxycodone; Oxycodone Hcl; Oxycodone Hydrochloride; Oxycodone [Usan:Ban:Inn]; Oxycodonum [Inn-Latin]; Oxycon; Oxycontin; PERCOCET; Pancodine; Percobarb; Percocet; Percodan; Roxicet; Roxicodone; Roxilox; Supendol [Canada]; Tecodin; Tekodin; Thecodine; Thekodin; Tylox
Dosage Forms
Tablet; Suppository
Absorption
well absorbed from OxyContin® tablets with an oral bioavailability of 60% to 87%
Interactions
Interactions for Oxycodone:
The CNS depressant effects of oxycodone hydrochloride may be additive with that of other CNS depressants..
Chemical IUPAC Name
4, 5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Chemical Formula
C18H21NO4
Half Life
4.5 hours
Drug Type
Approved Drug
# Accession No
APRD00387
CAS Registry Number
76-42-6