Ortho_Tri-Cyclen: profile and news

Report Shows Popular Birth Control Pill, Ortho Tri-Cyclen(R) LO ... May 11, 2006
The popular birth control pill, ORTHO TRI-CYCLEN(R) LO (norgestimate/ethinyl estradiol) Tablets, is not associated with an increased risk of pregnancy in ... - Medical News Today (press release),

Kaiser Daily Women's Health Policy Report Highlights Recently ... May 15, 2006
..."Higher Body Weight and BMI Are Not Associated With Reduced Efficacy in Ortho Tri-Cyclen Lo Users," Ortho-McNeil: Ortho-McNeil's Ortho Tri-Cyclen Lo is not ... - Kaiser network.org,

Weight Does Not Appear to Affect Oral Contraceptive Efficacy May 15, 2006
May 15, 2006 (Washington) — Despite reports the contrary, norgestimate/ethinyl estradiol (Ortho Tri-Cyclen Lo) is not associated with an increased risk of ... - Medscape (subscription)

Report Shows Popular Birth Control Pill, Ortho Tri-Cyclen Lo, Not ... May 10, 2006
WASHINGTON, DC -- May 9, 2006 -- The popular birth control pill, Ortho Tri-Cyclen ® Lo (norgestimate/ethinyl estradiol) Tablets, is not associated with an ... - DG News

Report Shows Popular Birth Control Pill, ORTHO TRI-CYCLEN(R) LO ... May 9, 2006
WASHINGTON, May 9 /PRNewswire/ -- The popular birth control pill, ORTHO TRI-CYCLEN(R) LO (norgestimate/ethinyl estradiol) Tablets, is not associated with an ... - PR Newswire (press release),

NEW BIRTH CONTROL pill promises less side effects (weight gain ... Apr 29, 2006
Ortho Tri-Cyclen LO, which has apparently been on the market for a couple of years, delivers a lower amount of estrogen—25 mcg (compared to 35 mcg in Ortho ... - ProgressiveU.org,

Birth-control patch linked to blood clots, strokes May 12, 2006
The company may have been nervous that it would lose money when its patent for the birth-control pill Ortho Tri-Cyclen ran out, the suits say, and pushed to ... - Bradenton Herald,

What Is Cystic Acne and How to Treat This Acne Apr 21, 2006
Oral contraceptives, including a combination of norgestimate and ethinyl estradiol (Ortho-Cyclen, Ortho Tri-Cyclen), have been shown to improve cystic acne in ... - Fashion Monitor Toronto,

From the Edge: Editorial Apr 27, 2006
To me, the word has a positive, and extremely important, meaning. It means I don't have to have kids if I don't want to (thanks Ortho Tri-Cyclen). ... - ASU Web Devil,

Prescriptions can assist acne cases where OTC options fail Apr 23, 2006
...bacteria. Contraceptives, such as Ortho Tri-cyclen and Yasmin, are also prescribed for acne patients, Brown said. Contraceptives ... - Monitor,

A shot of NASCAR's past Apr 22, 2006
65 Depends Dodge; the Remy Martin 500 at Martinsville Speedway; the No. 9 Ortho Tri-Cyclen Chevy (to counteract the No. 6 Viagra Ford). ... - Daily Press,

Other information

Indication
For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Pharmacology
Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent.

Mechanism Of Action
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Drug Category
Estrogens; ATC:G03CA01

Brand Names/Synonyms
17?-Ethynylestradiol; 17alpha-Ethinylestradiol; 17alpha-Ethynylestradiol; 17alpha-Ethynyloestradiol; Aethinyloestradiolum; Aethinyoestradiol [German]; Alesse; Alora; Amenoron; Amenorone; Anovlar; BRN 2419975; Binovum; Brevicon; Brevinor; CCRIS 286; CHEMBANK1139; Climara; Conceplan; Cyclosa; Demulen; Desogen; Dicromil; Diognat-E; Diogyn E; Diogyn-E; Diprol; Dyloform; EE; EE2; EO; ETHINYLESTRADIOL; Ertonyl; Esclim; Esteed; Estigyn; Estinyl; Eston-E; Estopherol; Estoral; Estoral {[Orion]}; Estorals; Estrace; Estraderm; Estradiol; Estring; Estrogel; Estrogen; Ethidol; Ethinoral; Ethinyl Estradiol; Ethinyl-Oestranol; Ethinylestradiolum [Inn-Latin]; Ethinylestriol; Ethinyloestradiol; Ethy 11; Ethynylestradiol; Ethynyloestradiol; Eticyclin; Eticyclol; Eticylol; Etinestrol; Etinestryl; Etinilestradiol [Inn-Spanish]; Etinilestradiolo [Dcit]; Etinoestryl; Etistradiol; Etivex; Feminone; Fempatch; Follicoral; Genora; Ginestrene; Gynodiol; Gynolett; HSDB 3587; Halodrin; Inestra; Innofem; Jenest; Kolpolyn; Levlen; Linoral; Lo/Ovral; Loestrin; Logynon; Lynoral; Marvelon; Menolyn; Menostar; Mercilon; Microfollin; Microgynon; Mircette; Modicon; NEE; NSC-10973; Necon; Nelova; Neo-Estrone; Neocon; Nogest-S; Norcept; Nordette; Norethin 1/35 E; Norimin; Norinyl; Norlestrin; Novestrol; Oradiol; Orestralyn; Orestrayln; Ortho Tri-Cyclen; Ortho-Cept; Ortho-Cyclen; Ortho-Novum; Ovcon; Ovex; Oviol; Ovral; Ovran; Ovranette; Ovysmen; Palonyl; Perovex; Primogyn; Primogyn C; Primogyn M; Progynon C; Progynon M; Prosexol; Spanestrin; Stediril; Synphase; Tetragynon; Thiuram E; Thiuranide; Tri-Levlen; Tri-Norinyl; Trinordiol; Trinovum; Triphasil; Vagifem; Varnoline; Vivelle; Ylestrol

Dosage Forms
DISC (SUSTAINED-RELEASE); GEL; IMPLANT; LIQUID; PATCH; RING (SLOW-RELEASE); SOLUTION; TABLET

Absorption
Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Interactions
Drug Interactions for Ethinyl Estradiol:

Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen:

Increased sulfobromophthalein retention; increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platel et aggregation; increased thyroid binding globulin (TBG) leading to increased circulating total thyroid hormone, as measured by PBI, T₄ by column, or T₄ by radioimmunoassay. Free T₃ resin uptake is decreased, reflecting the elevated TBG; free T₄ concentration is unaltered: impaired glucose tolerance; decreased pregnanediol excretion; reduced response to metyrapone test; reduced serum folate concentration; increased serum triglyceride and phospholipid concentration.

Chemical IUPAC Name
17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Chemical Formula
C20H24O2

Half Life
36 +/- 13 hours

Drug Type
Approved Drug

# Accession No
APRD00691

CAS Registry Number
57-63-6