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Other information

Indication
For the management of hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM)

Pharmacology
Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide.

Mechanism Of Action
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Drug Category
Hypoglycemic Agents; Sulfonylureas; ATC:A10BB03; ATC:V04CA01

Brand Names/Synonyms
Aglicid; Apo-Tolbutamide; Arkozal; Artosin; Artozin; BZ 55; Butamid; Butamide; D 860; Diaben; Diabetamid; Diabetol; Diabuton; Diasulfon; Dirastan; Dolipol; Drabet; Glyconon; HLS 831; Ipoglicone; Mobenol; Novo-Butamide; Orabet; Oralin; Orezan; Orinase; Orinase Diagnostic; Orinaz; Oterben; Pramidex; Rastinon; Restinon; Sk-Tolbutamide; Tolbusal; Tolbutamid; Tolbutamide; Tolbutamide.; Toluina; Tolumid; Toluvan; Tolylsulfonylbutylurea; U-2043; Willbutamide

Dosage Forms
TABLET

Absorption
Well absorbed, not affected by food consumption

Interactions
Not Available

Chemical IUPAC Name
3-butyl-1-(4-methylphenyl)sulfonyl-urea

Chemical Formula
C12H18N2O3S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00267

CAS Registry Number
64-77-7