Nordette: profile and news






Tributes Paid to the Late Science Fiction Writer Octavia Butler  07 Mar 2006
From New Jersey blogger and poet Nordette Adams comes this link to a four-part audio adaptation of Butler's most famous novel, Kindred, performed by the Seeing ... - Blogcritics.org,

Death of a Poet's Mother  07 Mar 2006
Reed; “Senryu Chain (5/7/5): I Did Not Know Her,� by Karla J. Dorman (The Stormspinner); and, “This Mother’s Son in Starlight,� by Nordette Adams. ... - PR Web (press release),

Third miscarriage, what to do?  Oct 2, 2005
...tablet. I was told the dosage was too low for me, so I switched to Nordette, but after two weeks the bleeding started again. The ... - Jamaica Observer,

Health Watch  Sep 14, 2005
...needs. We carry many brands of birth control pills (Alesse, Cyclessa, Mircette, Nordette, OrthoTriCyclen Lo), priced at $15 per pack. ... - Informer (subscription),

First line of defence  Aug 30, 2005
Australian clinicians will recognise this as merely tricycling Microgynon 30 or Nordette, which has long been done by women wanting to avoid a monthly ... - AustralianDoctor.com (subscription),

The Pill Brings Heart Risks  Jul 8, 2005
...contraceptives. They include brands such as Wyeth’s Lo/Ovral, Nordette, and Johnson & Johnson subsidiary Janssen-Ortho’s Tri-Cyclen Lo. ... - Red Herring <**results**>

The Pill Brings Heart Risks  Jul 8, 2005
...contraceptives. They include brands such as Wyeth’s Lo/Ovral, Nordette, and Johnson & Johnson subsidiary Janssen-Ortho’s Tri-Cyclen Lo. ... - Red Herring,

Health Watch  May 2, 2005
...needs. We carry many brands of birth control pills (Alesse, Cyclessa, Mircette, Nordette, OrthoTriCyclen Lo), priced at $15 per pack. ... - Informer (subscription)

Barr Reports Third Quarter Fiscal 2005 Earnings of $0.58 Per Share  May 5, 2005
...during the previous twelve months, including Loestrin®/Loestrin® Fe oral contraceptives, Plan B® emergency contraceptive, Nordette® oral contraceptive, and ... - Yahoo News

Barr Reports Third Quarter Fiscal 2005 Earnings of $0.58 Per Share  May 5, 2005
...acquired during the previous twelve months, including Loestrin(R)/Loestrin(R) Fe oral contraceptives, Plan B(R) emergency contraceptive, Nordette(R) oral ... - PharmaLive.com,

Health Center offers cheap birth control  Feb 15, 2005
These brands are Nordette, Cyclessa and Mircette. ... Nordette can range from $74 to $99, Mircette between $89 to $99, and Cyclessa from $22.50 to $106.80. ... - Quad (subscription),


Other information


Indication
For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Pharmacology
Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent.

Mechanism Of Action
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Drug Category
Estrogens; ATC:G03CA01

Brand Names/Synonyms
17?-Ethynylestradiol; 17alpha-Ethinylestradiol; 17alpha-Ethynylestradiol; 17alpha-Ethynyloestradiol; Aethinyloestradiolum; Aethinyoestradiol [German]; Alesse; Alora; Amenoron; Amenorone; Anovlar; BRN 2419975; Binovum; Brevicon; Brevinor; CCRIS 286; CHEMBANK1139; Climara; Conceplan; Cyclosa; Demulen; Desogen; Dicromil; Diognat-E; Diogyn E; Diogyn-E; Diprol; Dyloform; EE; EE2; EO; ETHINYLESTRADIOL; Ertonyl; Esclim; Esteed; Estigyn; Estinyl; Eston-E; Estopherol; Estoral; Estoral {[Orion]}; Estorals; Estrace; Estraderm; Estradiol; Estring; Estrogel; Estrogen; Ethidol; Ethinoral; Ethinyl Estradiol; Ethinyl-Oestranol; Ethinylestradiolum [Inn-Latin]; Ethinylestriol; Ethinyloestradiol; Ethy 11; Ethynylestradiol; Ethynyloestradiol; Eticyclin; Eticyclol; Eticylol; Etinestrol; Etinestryl; Etinilestradiol [Inn-Spanish]; Etinilestradiolo [Dcit]; Etinoestryl; Etistradiol; Etivex; Feminone; Fempatch; Follicoral; Genora; Ginestrene; Gynodiol; Gynolett; HSDB 3587; Halodrin; Inestra; Innofem; Jenest; Kolpolyn; Levlen; Linoral; Lo/Ovral; Loestrin; Logynon; Lynoral; Marvelon; Menolyn; Menostar; Mercilon; Microfollin; Microgynon; Mircette; Modicon; NEE; NSC-10973; Necon; Nelova; Neo-Estrone; Neocon; Nogest-S; Norcept; Nordette; Norethin 1/35 E; Norimin; Norinyl; Norlestrin; Novestrol; Oradiol; Orestralyn; Orestrayln; Ortho Tri-Cyclen; Ortho-Cept; Ortho-Cyclen; Ortho-Novum; Ovcon; Ovex; Oviol; Ovral; Ovran; Ovranette; Ovysmen; Palonyl; Perovex; Primogyn; Primogyn C; Primogyn M; Progynon C; Progynon M; Prosexol; Spanestrin; Stediril; Synphase; Tetragynon; Thiuram E; Thiuranide; Tri-Levlen; Tri-Norinyl; Trinordiol; Trinovum; Triphasil; Vagifem; Varnoline; Vivelle; Ylestrol

Dosage Forms
DISC (SUSTAINED-RELEASE); GEL; IMPLANT; LIQUID; PATCH; RING (SLOW-RELEASE); SOLUTION; TABLET

Absorption
Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Interactions
Drug Interactions for Ethinyl Estradiol:

Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen:

Increased sulfobromophthalein retention; increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platel et aggregation; increased thyroid binding globulin (TBG) leading to increased circulating total thyroid hormone, as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered: impaired glucose tolerance; decreased pregnanediol excretion; reduced response to metyrapone test; reduced serum folate concentration; increased serum triglyceride and phospholipid concentration.



Chemical IUPAC Name
17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Chemical Formula
C20H24O2

Half Life
36 +/- 13 hours

Drug Type
Approved Drug

# Accession No
APRD00691

CAS Registry Number
57-63-6

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