Nitrolingual: profile and news

First Horizon Announces Results for the First Quarter Ended March ... Apr 28, 2005
This is largely due to increased detailing on Sular(R), Nitrolingual(R) and the Prenate(R) line, which was rendered possible by the stopping of the promotion ... - Genetic Engineering News

First Horizon Pharmaceutical net income up Apr 28, 2005
..."This is largely due to increased detailing on Sular, Nitrolingual and the Prenate line, which was rendered possible by the stopping of the promotion of ... - Atlanta Business Chronicle,

First Horizon Announces Results for the First Quarter Ended March ... 29 Apr 2005
This is largely due to increased detailing on Sular(R), Nitrolingual(R) and the Prenate(R) line, which was rendered possible by the stopping of the promotion ... - Genetic Engineering News

First Horizon Pharmaceutical net income up 29 Apr 2005
..."This is largely due to increased detailing on Sular, Nitrolingual and the Prenate line, which was rendered possible by the stopping of the promotion of ... - Atlanta Business Chronicle,

Neponset starts Forest Labs at Sell Mar 11, 2005
Neponset expects combined sales of First Horizon's hypertension drug Sular and angina drug Nitrolingual -- $75 million in 2004 -- to increase to $84 million ... - BusinessWeek

Other information

Indication
For the prevention of angina

Pharmacology
Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.

Mechanism Of Action
Similar to other nitrites and organic nitrates, Nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Drug Category
Tocolytic Agents; Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA02

Brand Names/Synonyms
Adesitrin; Aldonitrin; Angibid; Anginine; Angiolingual; Angiplex; Angised; Anglix; Angonist; Angorin; Anogesic; Aquo-Trimitrosan; Aquo-Trinitrosan; Blasting Gelatin; Blasting Oil; Buccard; CCRIS 4089; CHEMBANK1827; Cardabid; Cardamist; Cardinit; Cardiodisco; Cascade; Chitamite; Colenitral; Corangil; Corangin Nitrokapseln; Cordipatch; Corditrine; Coro-Nitro; Dauxona; Deponit; Deponit 5; Deponit Tts 10; Deponit Tts 5; Deponit-5; Diafusor; Discotrine; Epinitril; Explosive Gum; GTN; Gepan Nitroglicerin; Gilucor; Gilucor Nitro; Gilustenon; Glonoin; Glonoine Oil; Glycerin Trinitrate; Glycerintrinitrate [Czech]; Glycerol Trinitrate; Glycerol, Nitric Acid Triester; Glyceroltrinitraat; Glyceroltrinitraat [Dutch]; Glyceryl; Glyceryl Nitrate; Glyceryl Trinitrate; Glycerylnitrat; Glytrin; Gtn-Pohl; HSDB 30; Hercol 2; Hercol 2x; Hercon 2; Hercon 2x; Hercosplit Wr; Herwicard; Herzer; Klavikordal; Lenitral; Lentonitrina; Mi-Trates; Millisrol; Minitram; Minitran; Mionitrat; Myocon; Myoglycerin; Myovin; NA 1204; NG; NK-843; NTG; NTS; Natispray; Neos Nitro Opt; Niglin; Niglycon; Niong; Niong Retard; Nirmin; Nit-Ret; Nitora; Nitradisc; Nitradisc Pad; Nitradisc Tts; Nitran; Nitrek; Nitric Acid Triester of Glycerol; Nitric Acid Triester of Gylcerol; Nitriderm; Nitriderm Tts; Nitrin; Nitrine; Nitrine-Tdc; Nitro Dur Tts; Nitro Mack; Nitro Mack Retard; Nitro Rorer; Nitro-Bid; Nitro-Dur; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Lent; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Prn; Nitro-Span; Nitro-Time; Nitroard; Nitrobaat; Nitrobid; Nitrobid Oint; Nitrobukal; Nitrocapt.D.; Nitrocerin; Nitrocine; Nitrocine 5; Nitroclyn; Nitrocontin; Nitrocontin Continus; Nitrocor; Nitrocot; Nitroderm; Nitroderm Tts; Nitroderm Tts Ext; Nitroderm Tts-5; Nitrodisc; Nitrodyl; Nitrodyl Tts; Nitrogard; Nitrogard-Sr; Nitroglicerina; Nitroglicerina [Italian]; Nitroglicerina [Spanish]; Nitrogliceryna; Nitrogliceryna [Polish]; Nitroglin; Nitroglycerin; Nitroglycerin Dynamite; Nitroglycerin Mixture With; Nitroglycerin [Usan:Jan]; Nitroglycerin in Dextrose 5%; Nitroglycerin, Spirits Of; Nitroglycerine; Nitroglycerine, Spirit Of; Nitroglycerol; Nitroglyn; Nitrol; Nitrol Creme; Nitrolan; Nitrolande; Nitrolar; Nitroletten; Nitrolingual; Nitrolingual Spray; Nitrolowe; Nitromel; Nitromex; Nitronal; Nitronet; Nitrong; Nitrorectal; Nitroretard; Nitrosigma; Nitrostabilin; Nitrostat; Nitrozell Retard; Nysconitrine; Orient Oil Yellow Gg; Percutol; Perglottal; Perlinganit; Petrol Yellow Wt; Propanetriol Trinitrate; Rcra Waste Number P081; Reminitrol; S.N.G; S.N.G.; SK-106N; SNG; Solution Glyceryl Trinitrate; Soup; Spirit of Glonoin; Spirit of Glyceryl Trinitrate; Spirit of Trinitroglycerin; Spirits of Nitroglycerin; Susadrin; Suscard; Sustac; Sustonit; Sutonit; TNG; Temponitrin; Transderm-Nitro; Transderm-Nitro Tts; Transiderm-Nitro; Tridil; Trinalgon; Trinitrin; Trinitrin Tablets; Trinitroglycerin; Trinitroglycerol; Trinitrol; Trinitrosan; UN 0143; UN 0144; UN 1204; Unigel; Vasoglyn

Dosage Forms
IV, ER tablets, SL tablets, ointment, Lingual Aerosol Spray, Transdermal Delivery System

Absorption
Not Available

Interactions
DRUG INTERACTIONS The vasodilating effects of nitroglycerin may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety. Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.

Chemical IUPAC Name
1,2,3-trinitrooxypropane

Chemical Formula
C3H5N3O9

Half Life
3 minutes

Drug Type
Approved Drug

# Accession No
APRD00153

CAS Registry Number
55-63-0