Nitroglycerin: profile and news






Natural Hormone May Prevent Premature Births  07 Mar 2006
The researcher is trying to find out if a hormone called progesterone can keep babies from being born too soon. "Since the '70s, actually ... - WRAL.com,

Testosterone And Manhood  07 Mar 2006
Prosperon adds 6- 12 mg progesterone. Progesterone is a precursor in men for the hormone testosterone. By applying 6-12 mg progesterone ... - DailyIndia.com,

Study Suggests MPA Is Effective Treatment For Hot Flashes  07 Mar 2006
However, concerns about a link between estrogen and progesterone combined therapy and an increased risk of breast cancer, heart disease and/or cognitive ... - Science Daily (press release)

Sex Chromosome Genes Influence Aggression Andmaternal Behavior ...  07 Mar 2006
Progesterone Regulates Male Behavior Toward Infants (February 26, 2003) -- In an unexpected discovery, a team led by Northwestern University scientists has ... - Science Daily (press release)

Phase II Trial Explores Faslodex® After Aromatase Inhibitor  07 Mar 2006
...these breast cancers will be hormone receptor-positive, meaning that they are stimulated to grow by the circulating female hormones estrogen and/or progesterone ... - Cancer Consultants (press release),

Great expectations  07 Mar 2006
Relaxed joints: Due to progesterone produced during the pregnancy (and which helps relax the pelvic joints for childbirth), the ligaments that support the ... - Charleston Post Courier (subscription),

Tips for Women and Men in Search of a Good Night's Sleep  Mar 5, 2006
With optimal levels of estrogen and progesterone in your system, the time it takes to fall asleep and the number of awakenings during the night decrease. ... - eMaxHealth.com,

Risks and benefits of estrogen are complicated  Mar 2, 2006
...and vaginal dryness. I stopped taking hormones because the progesterone component made me irritable and depressed. (I was taking ... - Bradenton Herald,

Lifestyle: Fewer periods could help women reduce cancer risk  Mar 5, 2006
...more periods than in primitive societies and each menstrual cycle leads to big swings in the ovarian hormones oestrogen and progesterone." ** Article Continues ... - FemaleFirst.co.uk,

Going for Plan B  Feb 27, 2006
Plan B is high dose of progesterone called Levonorgestrel (also used in the IUD Mirena). According to the New England Journal of ... - Cavalierdaily.com,

Faculty of Health  Mar 4, 2006
...had major errors. Of the women on hormones, 31% took estrogen alone and 57% a combination of estrogen and progesterone. Most of ... - Toronto Sun,

Good Morning, Sheridan Serotonin, stress, estrogen, oh my...  Mar 3, 2006
..."Each disorder involves a low level of serotonin aggravated by stress and is made worse by shifts in female hormones, estrogen and progesterone. ... - MyWebTimes.com,

Hormone could prevent premature births  Feb 20, 2006
Treating women with the female hormone progesterone could reduce their chances of giving birth too soon, recent research has suggested. ... - Daily Mail - UK,

Low fat diets not effective at lowering weight  Mar 4, 2006
Health Initiative study. Both articles do not emphasize that these women were also on estrogen and progesterone. The first article ... - Kennebec Journal,

Looking back over a 50-year career  Feb 27, 2006
...“I will give it to you. See if you can make it.�. Allan was asked to compound progesterone into a suppository that would dissolve in the uterus. ... - Cadillac News,

Growth Differentiation Factor-9 has Divergent Effects on ...  Feb 24, 2006
In FSH plus IGF-I-treated granulosa cells obtained from small follicles, 300 ng/mL of GDF-9 reduced (P<0.05) progesterone production by 15% and 600 ng/mL of GDF ... - Journal of Endocrinology

Columbia Laboratories to Discuss Fourth Quarter and Year End 2005 ...  Feb 24, 2006
Columbia markets Prochieve(R) 8% (progesterone gel) for progesterone supplementation as part of an Assisted Reproductive Technology treatment for infertile ... - Business Wire (press release),

HORMONE HOPES ON BIRTHS  Feb 19, 2006
...researchers hope. A study at the University of Glasgow will test whether taking doses of progesterone can prevent an early labour. Around ... - Glasgow Daily Record,

Racism, religious obscurantism and hypocrisy Australian parliament ...  Feb 20, 2006
...briefing paper prepared by parliament’s Social Policy Unit explains as follows: “RU486 works by blocking the effects of the hormone progesterone, which is ... - World Socialist Web Site,

Menopause: Women weigh risks of relief  Feb 23, 2006
...that there is no way to guarantee the safety or efficacy of blends, which use varying amounts of three naturally occurring estrogens, as well as progesterone. ... - Minneapolis Star Tribune (subscription),

Pregnant women affected by High levels of Stress more likely to ...  Feb 21, 2006
Another 2004 study by Nepomnaschy and his colleagues found when the cortisol levels were elevated there were also lower progesterone levels. ... - Best Syndication,

Stress linked to early miscarriage  Feb 21, 2006
...are consistent with a 2004 study in which Dr Nepomnaschy and his colleagues found that elevated cortisol levels were associated with lower progesterone levels. ... - Irish Health,

Fewer periods could help women reduce cancer risk  Mar 2, 2006
...society women have many more periods than in primitive societies and each menstrual cycle leads to big swings in the ovarian hormones oestrogen and progesterone ... - NewKerala.com,

Do Doctors Practice What They Preach?  Mar 1, 2006
...errors. Of the women on hormones 31 per cent took estrogen alone and 57 per cent a combination of estrogen and progesterone. Most ... - Canada Free Press,

Access to Birth Control under attack!  Mar 1, 2006
...belief that birth control pills and other forms of hormonal contraception--including the skin patch, the vaginal ring, and progesterone injections--cause tens ... - ProgressiveU.org,

Hormone 'may cut premature birth numbers'  Feb 20, 2006
A study is to look at whether the female hormone progesterone could cut the risk of women going into labour too early and their babies being born with serious ... - Glasgow Evening Times,

» Add new comment  Feb 21, 2006
...suggests that emergency contraception that employs the hormone progesterone rather than a mixture of the hormones estrogen and progesterone will not keep a ... - Media girl,

Lower Your Risk for Breast Cancer  Mar 2, 2006
Women are much more likely than men to have breast cancer. This is mostly because women have more estrogen and progesterone in their bodies. ... - Catanduanes Tribune,

Hormone May Prevent Premature Birth  Mar 2, 2006
...is. Scientists believe the natural progesterone works by relaxing muscles in the uterus, preventing early contractions. Smaller ... - WLNS,

Streicher  Feb 24, 2006
The vaginal ring delivers the lowest estrogen and progesterone levels of all estrogen-progesterone hormonal contraceptive options. ... - Chicago Sun-Times,

Stress ups miscarriage risk  Feb 27, 2006
...are consistent with a 2004 study in which his research team found that elevated cortisol levels were associated with lower levels of progesterone, a hormone ... - myDNA.com,

RU486 decision pleases instigator  Feb 16, 2006
...pregnant or less.". RU486 works because it is an anti-progesterone drug that inhibits pregnancy in its early stages. RU486 is used ... - ABC Regional Online,

On 2nd thought, estrogen can help  Feb 13, 2006
...limited to women who took only estrogen. Most women take a combination of estrogen and progesterone. However, a WHI study of the ... - Chicago Tribune,

Health News A service of Saint John's Health Center  Feb 17, 2006
Traditionally, these symptoms were treated with hormone therapy (HT), which is a combination of estrogen and progesterone. Three ... - The Lookout News,

March of Dimes Commits Additional $2.4 Million to Prematurity ...  Feb 6, 2006
Two projects focus on the role of the hormone progesterone in delaying early labor. Earlier studies have shown that giving women ... - HispanicBusiness.com,

Hormones the driving force between 'hi, honey' and 'shut up, dear'  Feb 6, 2006
A: If he can survive an entire hormone cycle, and she still likes him. Q: You also mention testosterone and progesterone. ... Progesterone is a sedating hormone. ... - Alameda Times-Star,

Estrogen May Reduce Risk of Heart Disease  Feb 13, 2006
For years, millions of women used the hormone alone or in combination with progesterone on the advice of doctors who believed it would alleviate hot flashes ... - Washington Post,

After Hysterectomy, Estrogen May Help Heart  Feb 13, 2006
...being published today in The Archives of Internal Medicine, concern the use of estrogen alone and differ from earlier studies of estrogen and progesterone. ... - New York Times,

RU486: Essential facts you need to know  Feb 16, 2006
A: It blocks the effects of the hormone progesterone, which is crucial to maintaining pregnancy. Without progesterone, the lining ... - NEWS.com.au,

SURPRISING STUDY RESULTS  Feb 19, 2006
...last week suggests estrogen does not increase heart disease in women who have had hysterectomies and therefore can take estrogen alone, without progesterone. ... - San Jose Mercury News,

Study revises view of hormones, heart woes  Feb 20, 2006
So the women in the study had been experiencing low levels of estrogen and progesterone for 10, 15, even 20 years before hormones were prescribed for them. ... - Chicago Sun-Times,

Studies Find Little Cancer Benefit in Low-Fat Diet for Older Women  Feb 7, 2006
The low-fat diet did seem to lower the risk of tumors that were negative for progesterone receptors (PR-) and tumors that were negative for progesterone ... - ACS News Center,

Study renews debate on use of estrogen  Feb 14, 2006
For years, millions of women used the hormone alone or in combination with progesterone on the advice of doctors. The Women’s ... - Kansas City Star,

Study: Stress Might Lead To Miscarriage  Feb 21, 2006
Cortisol and progesterone work together to keep the uterus ready for pregnancy. More studies are needed before the results of this study are widely accepted. ... - WBAL Channel.com,

Estrogen, Not Bad for Heart Health  Feb 17, 2006
The findings, published in the Archives of Internal Medicine, are limited to women who take estrogen only; most women take estrogen and progesterone together. ... - HeartZine,

Study clarifies benefits, risks of hormone therapy  Feb 22, 2006
...attack.". The findings, are limited to women who took only estrogen. Most women take a combination of estrogen and progesterone. However ... - Times Herald-Record,

Adjuvant Docetaxel More Effective Than Vinorelbine for Early ...  Feb 23, 2006
Patients with estrogen-receptor- or progesterone-receptor-positive tumors were also treated with tamoxifen 20 mg per day for up to 5 years, and radiation was ... - Cancerpage.com,


Other information


Indication
For the prevention of angina

Pharmacology
Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.

Mechanism Of Action
Similar to other nitrites and organic nitrates, Nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Drug Category
Tocolytic Agents; Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA02

Brand Names/Synonyms
Adesitrin; Aldonitrin; Angibid; Anginine; Angiolingual; Angiplex; Angised; Anglix; Angonist; Angorin; Anogesic; Aquo-Trimitrosan; Aquo-Trinitrosan; Blasting Gelatin; Blasting Oil; Buccard; CCRIS 4089; CHEMBANK1827; Cardabid; Cardamist; Cardinit; Cardiodisco; Cascade; Chitamite; Colenitral; Corangil; Corangin Nitrokapseln; Cordipatch; Corditrine; Coro-Nitro; Dauxona; Deponit; Deponit 5; Deponit Tts 10; Deponit Tts 5; Deponit-5; Diafusor; Discotrine; Epinitril; Explosive Gum; GTN; Gepan Nitroglicerin; Gilucor; Gilucor Nitro; Gilustenon; Glonoin; Glonoine Oil; Glycerin Trinitrate; Glycerintrinitrate [Czech]; Glycerol Trinitrate; Glycerol, Nitric Acid Triester; Glyceroltrinitraat; Glyceroltrinitraat [Dutch]; Glyceryl; Glyceryl Nitrate; Glyceryl Trinitrate; Glycerylnitrat; Glytrin; Gtn-Pohl; HSDB 30; Hercol 2; Hercol 2x; Hercon 2; Hercon 2x; Hercosplit Wr; Herwicard; Herzer; Klavikordal; Lenitral; Lentonitrina; Mi-Trates; Millisrol; Minitram; Minitran; Mionitrat; Myocon; Myoglycerin; Myovin; NA 1204; NG; NK-843; NTG; NTS; Natispray; Neos Nitro Opt; Niglin; Niglycon; Niong; Niong Retard; Nirmin; Nit-Ret; Nitora; Nitradisc; Nitradisc Pad; Nitradisc Tts; Nitran; Nitrek; Nitric Acid Triester of Glycerol; Nitric Acid Triester of Gylcerol; Nitriderm; Nitriderm Tts; Nitrin; Nitrine; Nitrine-Tdc; Nitro Dur Tts; Nitro Mack; Nitro Mack Retard; Nitro Rorer; Nitro-Bid; Nitro-Dur; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Lent; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Prn; Nitro-Span; Nitro-Time; Nitroard; Nitrobaat; Nitrobid; Nitrobid Oint; Nitrobukal; Nitrocapt.D.; Nitrocerin; Nitrocine; Nitrocine 5; Nitroclyn; Nitrocontin; Nitrocontin Continus; Nitrocor; Nitrocot; Nitroderm; Nitroderm Tts; Nitroderm Tts Ext; Nitroderm Tts-5; Nitrodisc; Nitrodyl; Nitrodyl Tts; Nitrogard; Nitrogard-Sr; Nitroglicerina; Nitroglicerina [Italian]; Nitroglicerina [Spanish]; Nitrogliceryna; Nitrogliceryna [Polish]; Nitroglin; Nitroglycerin; Nitroglycerin Dynamite; Nitroglycerin Mixture With; Nitroglycerin [Usan:Jan]; Nitroglycerin in Dextrose 5%; Nitroglycerin, Spirits Of; Nitroglycerine; Nitroglycerine, Spirit Of; Nitroglycerol; Nitroglyn; Nitrol; Nitrol Creme; Nitrolan; Nitrolande; Nitrolar; Nitroletten; Nitrolingual; Nitrolingual Spray; Nitrolowe; Nitromel; Nitromex; Nitronal; Nitronet; Nitrong; Nitrorectal; Nitroretard; Nitrosigma; Nitrostabilin; Nitrostat; Nitrozell Retard; Nysconitrine; Orient Oil Yellow Gg; Percutol; Perglottal; Perlinganit; Petrol Yellow Wt; Propanetriol Trinitrate; Rcra Waste Number P081; Reminitrol; S.N.G; S.N.G.; SK-106N; SNG; Solution Glyceryl Trinitrate; Soup; Spirit of Glonoin; Spirit of Glyceryl Trinitrate; Spirit of Trinitroglycerin; Spirits of Nitroglycerin; Susadrin; Suscard; Sustac; Sustonit; Sutonit; TNG; Temponitrin; Transderm-Nitro; Transderm-Nitro Tts; Transiderm-Nitro; Tridil; Trinalgon; Trinitrin; Trinitrin Tablets; Trinitroglycerin; Trinitroglycerol; Trinitrol; Trinitrosan; UN 0143; UN 0144; UN 1204; Unigel; Vasoglyn

Dosage Forms
IV, ER tablets, SL tablets, ointment, Lingual Aerosol Spray, Transdermal Delivery System

Absorption
Not Available

Interactions
DRUG INTERACTIONS The vasodilating effects of nitroglycerin may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety. Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.

Chemical IUPAC Name
1,2,3-trinitrooxypropane

Chemical Formula
C3H5N3O9

Half Life
3 minutes

Drug Type
Approved Drug

# Accession No
APRD00153

CAS Registry Number
55-63-0

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