Nitrofurazone: profile and news

EU rapid alert finds PSP toxins in live mussels from Spain Feb 7, 2006
07 February, 2006 - THE EU-rapid alert for week 5 found unauthorized substance nitrofuran (metabolite)-nitrofurazone (SEM) in raw frozen headless shell-on ... - Fishupdate.com,

Other information

Indication
For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.

Pharmacology
Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.

Mechanism Of Action
The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.

Drug Category
Trypanocidal Agents; Anti-Infectives

Brand Names/Synonyms
Actin-N; Aldomycin; Alfucin; Amifur; Babrocid; Becafurazone; Biofuracina; Biofurea; Chemofuran; Chixin; Cocafurin; Coxistat; Dermofural; Dymazone; Dynazone; Eldezol; Eldezol F-6; Fedacin; Flavazone; Fracine; Furacilin; Furacillin; Furacin; Furacin Soluble Dressing; Furacin Topical Cream; Furacin Topical Solution; Furacin-E; Furacin-Hc; Furacine; Furacinetten; Furacoccid; Furacort; Furacycline; Furaderm; Furagent; Furalcyn; Furaldon; Furalone; Furametral; Furan-Ofteno; Furaplast; Furaseptyl; Furaskin; Furatsilin; Furaziline; Furazin; Furazina; Furazol W; Furazone; Furazyme; Furesol; Furfurin; Furosem; Fuvacillin; Hemofuran; Ibiofural; Mammex; Mastofuran; Monafuracin; Monafuracis; Monofuracin; NF; NF-7; NFS; NFZ; NSC-2100; Nefco; Nfz Mix; Nifucin; Nifurid; Nifuzon; Nitrofural; Nitrofuraldehyde Semicarbazone; Nitrofuran; Nitrofurane; Nitrofurazan; Nitrofurazone; Nitrofurol; Nitrozone; Otofural; Otofuran; Sanfuran; Spray-Dermis; Spray-Foral; U-6421; Usaf Ea-4; Vabrocid; Vadrocid; Veterinary Nitrofurazone; Yatrocin

Dosage Forms
OINTMENT

Absorption
Well absorbed.

Interactions
Not Available

Chemical IUPAC Name
1-amino-N-[(5-nitro-2-furyl)methylideneamino]methanamide

Chemical Formula
C6H6N4O4

Half Life
5 hours

Drug Type
Approved Drug

# Accession No
APRD00050

CAS Registry Number
59-87-0