Nitrofurantoin: profile and news






Rethinking UTI Prophylaxis  Mar 1, 2006
1 This study demonstrates that ampicillin, nitrofurantoin, and third-generation cepholosporins may not be the appropriate initial therapy for patients with a ... - AAP Grand Rounds (subscription)

A Review of Pregnancy Outcomes After Exposure to Orally Inhaled or ...  Aug 12, 2005
...infant cardiovascular defects, including insulin, antihypertensives, fertility drugs, erythromycin, naproxen, anticonvulsants, nitrofurantoin, and clomipramine ... - RedNova.com,

Isopak announces spiral jet mill results  Aug 1, 2005
Drugs such as amphotericin, fluocinolone acetonide, medroxyprogesterone acetate, bishydroxycoumarin, nitrofurantoin, tolbutamide, and spironolactone have shown ... - in-PharmaTechnologist

Essential drug not available in Mumbai  Jul 15, 2005
The drug, Nitrofurantoin—sold under the brand name Furadantin—has not been available in the city for the last three months. ... - Mumbai Newsline <**results**>

New Oncology Strategy: Molecular Targeting of Cancer Cells  Jun 29, 2005
...use of other medications associated with peripheral neuropathy such as statins (Pravachol, Lipitor), isoniazid (INH), nitrofurantoin (Macrodantin), or ... - RedNova.com,

Pillbox: Nitrofurantoin  Apr 17, 2005
Notes: Furadantin, which is a derivative of nitrofuran, works by effectively killing the bacteria found in the urinary tract. Dosage ... - Scotsman

Ranbaxy receives FDA approval to market Nitrofurantoin  Mar 31, 2005
Laboratories (Q, N,C,F)* Ltd has received approval from the US Food and Drug Administration to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - Myiris.com

Eon Labs Receives Final Approval for Nitrofurantoin Monohydrate ...  Apr 7, 2005
...(Nasdaq: ELAB) announced that it received final approval today of Nitrofurantoin Monohydrate/Macrocrystals 100mg capsules, the generic equivalent to Macrobid(R ... - PharmaLive.com

US nod for Ranbaxy's antibiotic  Apr 1, 2005
It said Ranbaxy had received approval to market 100 mg nitrofurantoin monohydrate/macrocrystals capsules, which are indicated for the treatment of urinary ... - Hindu Business Line

Ranbaxy gets FDA nod to make capsules  Mar 31, 2005
01, 2005, that the company has received approval from the US Food and Drug Administration to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - Sify

Ranbaxy Receives FDA Approval To Market A Generic Alternative To ...  Apr 2, 2005
...today that the Company has received approval from the US Food and Drug Administration to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - Medical News Today

Macrobid...Ranbaxy wins FDA nod to market its generic alternative  Mar 31, 2005
...on Friday announced that it has received approval from the US Food and Drug Administration to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - India Infoline.com

Ranbaxy gets USFDA nod for Macrobid®'s alternate  Mar 31, 2005
Ranbaxy Laboratories has received approval from the US Food and Drug Administration (USFDA) to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - Business Standard

Ranbaxy gets USFDA nod for new drug  Apr 1, 2005
Laboratories on Friday said it had received approval from US Food and Drug Administration to manufacture and market nitrofurantoin monohydrate macrocrystals ... - Rediff

US approves new drug by Ranbaxy  Apr 3, 2005
...pharma major Ranbaxy Laboratories Limited (RLL), announced that the FDA had allowed it to manufacture and market Nitrofurantoin Monohydrate/Macrocrystals ... - PlanetGuru

US nod for Ranbaxy's antibiotic  Apr 18, 2005
The company has said it has received approval to market 100 mg nitrofurantoin monohydrate/macrocrystals capsules, which are indicated for the treatment of ... - Algorum

FDA approves Ranbaxy generic drug  Apr 1, 2005
...treat urinary tract infections. Ranbaxy plans to begin marketing nitrofurantoin monohydrate by the end of the month. The drug is ... - Jacksonville Business Journal

Taking liver-taxing drugs calls for periodic testing  Apr 5, 2005
...nabumetone (Relafen), nefazodone (Serzone), naproxen (Naprosyn, Aleve), nevirapine (Viramune), niacin (Niaspan), nitrofurantoin (Macrodantin), oxaprozin (Daypro ... - Contra Costa Times,

Three-Day Antibiotic Regimens for Treating Bladder Infection in ...  Feb 22, 2005
...resistance is high (greater than 20 percent) or in women who have risk factors for trimethoprim-sulfamethoxazole resistance, nitrofurantoin or a ... - Newswise (press release)

Antibiotics for UTIs  Feb 22, 2005
They say trimethoprim-sulfamethoxazole (Bactrim or Septra) should continue to be the first line of treatment, and the second line should be nitrofurantoin or a ... - Ivanhoe


Other information


Indication
For the treatment of infection (urinary tract)

Pharmacology
Nitrofurantoin, a nitrofuran antibacterial agent, is available in microcrystalline and macrocrystalline form to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria.

Mechanism Of Action
Nitrofurantoin inhibits bacterial acetyl-coenzyme A, interfering with the organism's carbohydrate metabolism. The drug also can disrupt bacterial cell wall formation.

Drug Category
Anti-Infectives; Anti-Infectives; ATC:J01XE01

Brand Names/Synonyms
Alfuran; Apo-Nitrofurantoin; Benkfuran; Berkfurin; Ceduran; Chemiofuran; Cistofuran; Cyantin; Cystit; Dantafur; Fua Med; Fuamed; Fur-Ren; Furabid; Furachel; Furadantin; Furadantin Retard; Furadantina Mc; Furadantine; Furadantine Mc; Furadantine-Mc; Furadantoin; Furadoin; Furadoine; Furadonin; Furadonine; Furadontin; Furalan; Furaloid; Furan; Furanite; Furantoin; Furantoina; Furatoin; Furedan; Furina; Furobactina; Furophen T; Furophen T-Caps; Gerofuran; It-Uran; Ituran; Ivadantin; Macpac; Macrobid; Macrodantin; Macrodantina; Macrofuran; Macrofurin; N-Toin; NSC-2107; Nierofu; Nifurantin; Nitoin; Nitrex; Nitrofan; Nitrofur-C; Nitrofuradantin; Nitrofurantoin; Novo-Furantoin; Novofuran; Orafuran; Parfuran; Phenurin; Ro-Antoin; Siraliden; Trantoin; Uerineks; Upiol; Urantoin; Urizept; Uro-Selz; Uro-Tablinen; Urodin; Urofuran; Urofurin; Urolisa; Urolong; Usaf Ea-2; Uvaleral; Welfurin; Zoofurin

Dosage Forms
TABLET

Absorption
Not Available

Interactions
-->Interactions for Nitrofurantoin:

Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.

Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.

Drug/Laboratory Test Interactions

As a result of the presence of nitrofurantoin, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions but not with the glucose enzymatic test.



Chemical IUPAC Name
1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione

Chemical Formula
C8H6N4O5

Half Life
0.3-1 hour.

Drug Type
Approved Drug

# Accession No
APRD00191

CAS Registry Number
67-20-9

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