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Nitrofurantoin: profile and news
Rethinking UTI Prophylaxis Mar 1, 2006 A Review of Pregnancy Outcomes After Exposure to Orally Inhaled or ... Aug 12, 2005 Isopak announces spiral jet mill results Aug 1, 2005 Essential drug not available in Mumbai Jul 15, 2005 New Oncology Strategy: Molecular Targeting of Cancer Cells Jun 29, 2005 Pillbox: Nitrofurantoin Apr 17, 2005 Ranbaxy receives FDA approval to market Nitrofurantoin Mar 31, 2005 Eon Labs Receives Final Approval for Nitrofurantoin Monohydrate ... Apr 7, 2005 US nod for Ranbaxy's antibiotic Apr 1, 2005 Ranbaxy gets FDA nod to make capsules Mar 31, 2005 Ranbaxy Receives FDA Approval To Market A Generic Alternative To ... Apr 2, 2005 Macrobid...Ranbaxy wins FDA nod to market its generic alternative Mar 31, 2005 Ranbaxy gets USFDA nod for Macrobid®'s alternate Mar 31, 2005 Ranbaxy gets USFDA nod for new drug Apr 1, 2005 US approves new drug by Ranbaxy Apr 3, 2005 US nod for Ranbaxy's antibiotic Apr 18, 2005 FDA approves Ranbaxy generic drug Apr 1, 2005 Taking liver-taxing drugs calls for periodic testing Apr 5, 2005 Three-Day Antibiotic Regimens for Treating Bladder Infection in ... Feb 22, 2005 Antibiotics for UTIs Feb 22, 2005 Other information Indication For the treatment of infection (urinary tract) Pharmacology Nitrofurantoin, a nitrofuran antibacterial agent, is available in microcrystalline and macrocrystalline form to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria. Mechanism Of Action Nitrofurantoin inhibits bacterial acetyl-coenzyme A, interfering with the organism's carbohydrate metabolism. The drug also can disrupt bacterial cell wall formation. Drug Category Anti-Infectives; Anti-Infectives; ATC:J01XE01 Brand Names/Synonyms Alfuran; Apo-Nitrofurantoin; Benkfuran; Berkfurin; Ceduran; Chemiofuran; Cistofuran; Cyantin; Cystit; Dantafur; Fua Med; Fuamed; Fur-Ren; Furabid; Furachel; Furadantin; Furadantin Retard; Furadantina Mc; Furadantine; Furadantine Mc; Furadantine-Mc; Furadantoin; Furadoin; Furadoine; Furadonin; Furadonine; Furadontin; Furalan; Furaloid; Furan; Furanite; Furantoin; Furantoina; Furatoin; Furedan; Furina; Furobactina; Furophen T; Furophen T-Caps; Gerofuran; It-Uran; Ituran; Ivadantin; Macpac; Macrobid; Macrodantin; Macrodantina; Macrofuran; Macrofurin; N-Toin; NSC-2107; Nierofu; Nifurantin; Nitoin; Nitrex; Nitrofan; Nitrofur-C; Nitrofuradantin; Nitrofurantoin; Novo-Furantoin; Novofuran; Orafuran; Parfuran; Phenurin; Ro-Antoin; Siraliden; Trantoin; Uerineks; Upiol; Urantoin; Urizept; Uro-Selz; Uro-Tablinen; Urodin; Urofuran; Urofurin; Urolisa; Urolong; Usaf Ea-2; Uvaleral; Welfurin; Zoofurin Dosage Forms TABLET Absorption Not Available Interactions -->Interactions for Nitrofurantoin: Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate. Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial. Drug/Laboratory Test Interactions As a result of the presence of nitrofurantoin, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions but not with the glucose enzymatic test. Chemical IUPAC Name 1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione Chemical Formula C8H6N4O5 Half Life 0.3-1 hour. Drug Type Approved Drug # Accession No APRD00191 CAS Registry Number 67-20-9 |
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