Nicotine: profile and news






At 61, answering Uncle Sam's call  07 Mar 2006
...combat stress. "I was eating about a roll of Tums a day and drinking a quart and a half of milk to keep my stomach settled. My wife ... - Philadelphia Inquirer,

Mums find way to youngsters' tums  Feb 8, 2006
Milton Road Primary School in Chesterton, Cambridge, drafted in Melissa Plowden Roberts and Amanda Harris to make school lunches both healthy and tasty. ... - Cambridge Evening News,

Young scientists put products to test  Mar 5, 2006
Shikha Talwar, an eighth-grade student at Voorhees Middle School, will tell you that Tums work best in fighting acid. She compared ... - Cherry Hill Courier Post,

Milford to allow kids to get Tylenol from nurse  Mar 2, 2006
...agreed with the plan, but some want Milford school nurses also to stock up on other non-prescription medicines, like ibuprofen, Benadryl and Tums, as they do ... - Milford Daily News,

TV: 'Conviction' guilty of being lazy, too pretty, boring  Mar 2, 2006
Balfour, who was not convincing as a detective in the defunct "Hawaii" or as an assistant DA in this series, spends most of his time chewing Tums and drinking ... - Salt Lake Tribune,

Blue Dragons win Nutmeg title  Mar 4, 2006
..."This was a first time for my kids in a meet like this and they were nervous. We went through a lot of TUMS before the meet.". Plainville ... - Middletown Press,

In the Land of Casseroles  Feb 23, 2006
Dennis, author of “Hotdish Haiku� (with recipes for “House of Blue Tums Hotdish� and “Nirvana in Pyrex�) and “Hotdish to Die For� (a hysterical ... - Mason City Globe Gazette,

Whelton: The uncharted territory of a woman's purse  Feb 17, 2006
..."There's a roll of Tums in there that I'd like.". "I don't see any purse," I said, twisting my head around. ... The Tums should be inside.". "Let's see," I said. ... - Norton Mirror,

For Football Fans, Day-After Nausea Isn't So Super  Feb 5, 2006
Petersburg. "I've got Tums at home, so I'll be all right.". Smith, a Steelers fan, began eating about 1 pm Sunday at Rudy's Sports Cafe on 66th Street North. ... - Tampa Tribune,

'Gentleman Joe' retains paczki dominance  Mar 1, 2006
That went down smoothly. The rest were jelly and I was hurting," said the mayor, whose strategy included "taking Tums and Lipitor" before the contest. ... - Connecticut Post,

Milford to review giving Tylenol to sick kids  Mar 1, 2006
Similar procedures are in place in Taunton and Northbridge, which also allows students to take ibuprofen, Benadryl and Tums during the school day. ... - Milford Daily News,

Mild-mannered mom picks up hockey habit  Mar 3, 2006
...drug. She started popping Tums 'round the clock to cope with the acid indigestion generated by playoff games and Ice Palace nachos. ... - The Free Lance-Star,

Italian ties, T-shirts, and upset stomachs  Mar 1, 2006
...victims. If your stomach is sick, buy some Tums and send the bill to Shawn Connelly, in care of the McDonough County Jail. Shirt ... - Peoria Journal Star,

Share the love  Feb 13, 2006
...it’s not love after all; it’s just indigestion. Cancel the dinner date, take two Tums and call her in the morning to apologize. - Anderson Independent Mail (subscription),

Supplies needed for emergency ahead of time  Feb 5, 2006
First aid kit: in a plastic Zip-loc bag: make up your own basic kit to include bandages, gauze pads, aspirin, neosporin, scissors, Tums, assorted safety pins ... - North County Times,

It'd be great (but unlikely) to see the stars match up  Feb 21, 2006
...level. That's why the ABC suits this week will down buckets of Tums while praying the marquee players prevail into the weekend. ... - SI.com

Trade Analysis: Francis traded for Hardaway, Ariza  Feb 22, 2006
Larry Brown is going to be popping Tums like candy in the days ahead. That's why it's likely we'll see either Marbury or Crawford traded soon. ... - CNN International

Here comes the brides  Feb 23, 2006
...night it is. He loves and is loved by them all. He pops Viagra daily, and somewhere he must keep a stash of Tums. The wives, played ... - Denver Post,

Austin Siebert looking to see time in all three divisions within ...  Feb 22, 2006
Stated Austin’s Father, Travis. “I have to eat a roll of Tums every time we go� the elder Siebert laughed! In addition to his ... - Auto Racing Daily

Does acid reflux lead to cancer?  Feb 23, 2006
...bones. Calcium carbonate tablets can also provide the daily calcium requirement. Tums is calcium carbonate, and it's an antacid. It ... - Sarasota Herald-Tribune,

MOUNTAIN VIEWS: NEWS STORIES JUST UNDER THE RADAR  Feb 20, 2006
1) Big Oil Ripoff -- If you hear the term "royalty relief," what comes to mind? Giving Queen Elizabeth a pack of Tums? Would that it were that innocent. ... - Niagarafallsreporter.com,

Capacity building allocation exhausted  Feb 21, 2006
He said their request was approved, adding that they were currently attending a workshop at Tums’s George hotel where they are being mentored. ... - The Swazi Observer,

It's in the Bag – Somewhere  Feb 26, 2006
Nevertheless, since she has a purse, she ends up packing his car keys, wallet, cell phone, appointment book, iPod, ear buds, Tums, nail clippers, Swiss Army ... - Hurricane Valley Journal,

Natural gas: 'The Last Taboo'  Feb 19, 2006
..."What you need are full-range digestive enzymes if you're going to have a great big meal. And not just Tums," she says. "Tums just neutralizes stomach acids. ... - Cherry Hill Courier Post,

Pregnant stars look swell in the sun  Feb 19, 2006
Fashion fans Katie Holmes, Gwyneth Paltrow and Gwen Stefani had their tums proudly on display in some of the world's coolest resorts. ... - Glasgow Daily Record,

Meet the 'first losers'  Feb 21, 2006
Particularly with Austrian legends Hermann Maier and Benjamin Raich and US star Bode Miller lurking ominously behind him. Anyone got a Tums? ... - Vancouver Sun (subscription),

Lions and Tigers and Taxes – "Oh, my!"  Feb 2, 2006
...all year long. So get out your calculator, extra Wite-Out and Tums. Or better yet, give us a call and let us help you. Tax year ... - Hurricane Valley Journal,

Commentary: Fed's Bernanke will play for times  Feb 7, 2006
...having a short-term trading strategy for the new Bernanke Fed, how about trying a spread -- buy Pepto-Bismol (Procter & Gamble) or Tums (GlaxoSmithKline) and ... - MarketWatch

FAN GUIDE TO SUPER BOWL XL  Feb 5, 2006
...dramatically in the weeks leading up to the game simply to meet demand. One would also assume more Alka-Seltzer and Tums are con-. - Asbury Park Press,

Bears upset Panthers  Feb 12, 2006
After a turnover, Jacobson made two free throws with 22.9 seconds to go to make it 64-63. It was Tums time for Bears' fans again. ... - News-Leader.com,

Luncheon will focus on message of late pope  Feb 18, 2006
The medical mission to Honduras is seeking donations of Tylenol, ibuprofen tablets, cough and cold medicine, Tums and snack or sandwich-sized plastic bags ... - Akron Beacon Journal,

Hard sell: Trying to sway FutureGen  Feb 5, 2006
Before they could reach for their first Tums, Perryman asked them if they wanted his 20-minute spiel for why Henderson County was the best place in America for ... - Athens Daily Review,

Vermont families find Olympic journey has its costs  Feb 12, 2006
A lot of intense stuff is going to happen — the ups and downs, the highs and lows. My wife used to take a package of Tums. There ... - Barre Montpelier Times Argus,

Pelham girl cheers as once-ailing giraffe's now a dad  Feb 6, 2006
...to feed Beau a special diet, and Grossenbacher said the giraffe can be fussy, insisting on specific brands such as Arm & Hammer baking soda and Tums for his ... - Lowell Sun,

From the Editor's Desk: Housing authority desperately needs fixing  Feb 11, 2006
...for political purposes. Before Wednesday night's meeting, Romeo called Gentry over and gave him a pack of Tums. Unfortunately, it ... - The Southern,

Food News for February 15-February 21  Feb 14, 2006
DOWNTOWN. Tums sales will surely skyrocket as Pike Place Market's fourth annual Chili and Barbecue Competition fires up. Fifteen ... - Seattle Weekly,

Reality TV cooking isn't enough for a real appetite  Feb 7, 2006
...than mine. Never did find out why and certainly wasn't going to ask. Food is for filling empty tums - that's reality. There must ... - ic Coventry,

The Starling Chronicles  Feb 11, 2006
...we adapted to cat food, Nine Lives mixed with Mott's natural apple sauce (no sugar for starlings, only corn syrup or fruit sweeteners), ground Tums (for calcium ... - New York Times,

Overtime nothing new to Wildcats  Feb 15, 2006
...show. You can understand why veteran Woodbury Central Coach Terry Horsley has consumed a few more Tums for the tummy this season. ... - Sioux City Journal,

Tracking heartburn  Feb 7, 2006
...month.". "People used to just take a Tums and said they had heartburn," said Norma Berthiaume, a registered nurse in the department. ... - The Republican,

Psychiatric morbidity among sentenced prisoners: prevalence study ...  Feb 9, 2006
Tehran 13337, Iran. Tel: +98 21 5541 2222; fax: +98 21 5541 9113; e-mail: assadism{at}sina.tums.ac.ir. Background Information on ... - British Journal of Psychiatry (subscription),

Avoid the knife if you can withstand the needle  Feb 8, 2006
But specialists in the US are now treating grade five cellulite - the most severe form - by injecting chemical fillers under the skin in bums, tums and thighs. ... - Scotsman,

Saints try to move on after back-to-back one-point losses  Feb 15, 2006
The rewind button to his VCR is nearly worn out. His bottle of Tums is empty. All week, Keith Cooper, with a death grip on the VCR ... - The Olympian,

Training program to ready 120 new workers  Feb 4, 2006
...on the heels of manufacturing job loss in the region with recent layoff announcements at the American Coal Company in Saline County, the TUMS packaging plant ... - The Southern,

Flipping through the pages of dedication, wisdom  Feb 17, 2006
Odette Daigle catches all of the sisters’ attention: A picture of “Hansel and Gretel: the Later Years� portrayed an edible house of Tums, bran flakes and ... - The Ranger,


Other information


Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation

Pharmacology
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.

Mechanism Of Action
Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

Drug Category
Anti-craving Agents; Central Nervous System Agents; Autonomic drugs; Nicotinic Agonists; ATC:N07BA01

Brand Names/Synonyms
Black Leaf; Black Leaf 40; Campbell's Nico-Soap; Commit; Destruxol Orchid Spray; Emo-Nik; Flux Maag; Fumetobac; Habitrol; L-Nicotine; Mach-Nic; Niagara P.A. Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide; Nicoderm; Nicoderm Cq; Nicorette; Nicorette Plus; Nicotin; Nicotina; Nicotine; Nicotine Alkaloid; Nicotine Polacrilex; Nicotrol; Nicotrol Inhaler; Nicotrol Ns; Nikotin; Nikotyna; Ortho N-4 Dust; Ortho N-5 Dust; Prostep; Tendust; Tetrahydronicotyrine, Dl-; Xl All Insecticide

Dosage Forms
Gum, Inhaler, Patches

Absorption
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Interactions
Interactions for Nicotine:

Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.



Chemical IUPAC Name
3-(1-methylpyrrolidin-2-yl)pyridine

Chemical Formula
C10H14N2

Half Life
Cotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours

Drug Type
Approved Drug

# Accession No
APRD00200

CAS Registry Number
54-11-5

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