Nicorette: profile and news






The Sweet Thereafter  06 Mar 2006
...added calories. Nutritive sweeteners include refined sugar, honey, high fructose corn syrup, dextrose and sugar alcohols. Sucrose ... - Natural Products Industry Insider,

Emergency departments score poorly in child-saving drills  06 Mar 2006
For example, of the 35 EDs studied, 34 failed to administer dextrose properly to a child in hypoglycemic shock ( a life-threatening sharp drop in blood sugar ... - PressZoom (press release),

No bandages, antibiotics … no dextrose; Mayor fears most of ...  Feb 17, 2006
...medical aid materials and medicines. “We have no bandages, antibiotics and no dextrose�, he said. The village has been experiencing ... - Arab Times,

Glucose changes can cause damage  Mar 5, 2006
Sugars or starches are digested in our digestive tract and broken down into a very simple sugar -- glucose, also known as D-glucose or dextrose. ... - Orlando Sentinel,

Supplement May Not Aid Performance  Feb 26, 2006
Advocates claim it can improve athletic performance, so the researchers decided to compare ribose to plain ole dextrose -- a common sugar. ... - abc7news.com,

What's really in them?  Feb 24, 2006
Potatoes, partially hydrogenated soybean oil, natural flavor (beef, wheat and dairy sources), dextrose, sodium acid pyrophosphate (to preserve natural color). ... - Pittsburgh Tribune-Review,

Do Supplements Improve Athletes' Performance?  Feb 13, 2006
They compared two groups of female rowing teams for eight weeks. One group took ribose, the other dextrose -- a sugar in sweeteners and sport drinks. ... - Pittsburgh Channel.com,

Harare Hospital's Casualty Disaster  Feb 27, 2006
Supplies of drugs used for resuscitation such as atropine, adrenalin and dextrose that sources said were used in cadio pulmonary resuscitation, are erratic and ... - AllAfrica.com,

Russian River filled with Damnation  Mar 1, 2006
It's made with a Belgian yeast strain; American pilsner barley malt and dextrose sugar, which contributes more alcohol and a teasing lightness. ... - Inside Bay Area,

Oxoid, expert in pharmaceutical microbiology  Mar 1, 2006
...come in an assortment of triple wrapped and irradiated formats, and contain Tryptone soya agar, a general purpose medium; or Sabouraud dextrose agar, ideal for ... - Laboratory Talk,

Water vapour permeability testing of medical packs  Mar 1, 2006
...deliquescence (such as calcium chloride, chloral hydrate), dilution (such as glycerol, lactic acid), going moldy (such as dextrose, pepsin), hydroxylation ... - Laboratory Talk,

Roquetrte Freres to acquire 14.95 pc stake in Riddhi Siddhi  Feb 14, 2006
...starch and starch derivatives manufacturer and produces a variety of starch and its derivatives such as liquid glucose, dextrose monohydrate, maltodextrin and ... - Webindia123,

Deciphering food label lingo  Feb 22, 2006
...t have added sugars, while the fruit yogurt probably lists corn syrup, high-fructose corn syrup, fruit juice concentrate, maltose, dextrose, sucrose, honey ... - Jamaica Observer,

McDonald's news fries parents of allergic kids  Feb 15, 2006
At the end of a long list of ingredients--including partially hydrogenated soybean oil and dextrose--was the single offending line: "Contains wheat and milk ... - Chicago Tribune,

Controversial practitioner leaves legal trail at border  Feb 3, 2006
Ongley injects his solution – identified as a mixture of phenol, glycerine, dextrose, distilled water and a local anesthetic – into patients' injured ... - San Diego Union Tribune,

Riddhi Siddhi completes expansion  Feb 2, 2006
RSGBL produces variety of starch and its derivatives such as liquid glucose, dextrose monohydrate, maltodextrin, dextrose syrup, high maltose corn syrup and ... - Sify,

Woman Sues McDonalds Over Allergic Reaction to French Fries  Feb 18, 2006
At the end of a long list of ingredients, including partially hydrogenated soybean oil and dextrose, was the line: "Contains wheat and milk ingredients.". ... - AXcess News,

Adelson: Miller, others visited banned medicine man  Feb 1, 2006
Ongley injects patients with something called the "Ongley Solution," which he says is a mixture of 25 percent dextrose, 25 percent glycerin, 2.5 percent phenol ... - abc7.com,

Riddhi Siddhi Gluco wins Rs60mn Heinz India order  Feb 2, 2006
RSGBL produces variety of starch and its derivatives such as Liquid Glucose, Dextrose Monohydrate, Maltodextrin, Dextrose Syrup, High Maltose Corn Syrup and ... - India Infoline.com,

Pain and prejudice  Feb 7, 2006
The injection he administers, which he calls "The Ongley Solution," is a combination of dextrose, glycerin, and phenol designed to create an inflammatory ... - Yahoo! Sports

Straight from the Mule's Mouth  Feb 6, 2006
Olney, who operates out of a small shack a few hours' drive from San Diego, injects his patients with a mixture of dextrose, glycerin, phenol and distilled ... - The Dartmouth,

Cargill targets polyol growth with new maltitol facility  Feb 15, 2006
HP maltitol and Eridex erythritol are two unique products in the Cargill polyol line," said Kathy Fortmann, product manager, polyols and dextrose Americas, for ... - FoodNavigator.com,

A Ski Run for Border  Feb 9, 2006
...the Ongley solution.". Ongley's website says the solution consists of dextrose, glycerin, phenol and distilled water. Phenol is a ... - Los Angeles Times,

Magic 4 Life  Feb 6, 2006
This involves clearing the toxins in the body by using a fluid treated with dextrose four times a day or by using Automated Peritoneal Dialysis (APD) using a ... - di-ve.com,

Miller takes third, then tough questions  Feb 4, 2006
ESPN The Magazine reported that Ongley injects patients with the ''Ongley Solution," which he says is a mixture of 25 percent dextrose, 25 percent glycerin ... - Boston Globe,

Corn Products International to Webcast Presentation at JP Morgan ...  Feb 9, 2006
The Company, headquartered in Westchester, Ill., is the number-one worldwide producer of dextrose and a leading regional producer of starch, high fructose corn ... - Yahoo! News (press release)

State of Illinois Proclaims Corn Products International Day  Feb 6, 2006
Corn Products International is the number- one worldwide producer of dextrose and a leading regional producer of starch, high fructose corn syrup and glucose. ... - PR Newswire (press release),

Corn Products International Rings NYSE Closing Bell(SM) Today  Feb 6, 2006
Corn Products International is the number-one worldwide producer of dextrose and a leading regional producer of starch, high fructose corn syrup and glucose. ... - PR Newswire (press release),

Bode among skiers to use controversial doctor  Feb 1, 2006
Ongley injects patients with something dubbed the "Ongley Solution," which he says is a mixture of dextrose, glycerin, phenol and distilled water. ... - MSNBC

Riddhi Siddhi bags Rs 6 cr from Heinz;completes expansion prog  Feb 2, 2006
RSGBL produces variety of starch and its derivatives such as liquid glucose, dextrose monohydrate, maltodextrin, dextros syrup, high maltose corn syrup and the ... - Hindu,

Miller, US skiers travel to Mexico for 'solution' injections  Feb 2, 2006
...to ESPN The Magazine, Ongley injects patients with something called the “Ongley Solution,� which he says is a mixture of 25 percent dextrose, 25 percent ... - San Diego Union Tribune,

Food labels can be tricky to interpret correctly  Feb 1, 2006
...intake. To assess sugar levels, examine the list of ingredients, looking for sugar, honey, corn syrup, fructose, maltose or dextrose. ... - Newstarget.com,


Other information


Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation

Pharmacology
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.

Mechanism Of Action
Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

Drug Category
Anti-craving Agents; Central Nervous System Agents; Autonomic drugs; Nicotinic Agonists; ATC:N07BA01

Brand Names/Synonyms
Black Leaf; Black Leaf 40; Campbell's Nico-Soap; Commit; Destruxol Orchid Spray; Emo-Nik; Flux Maag; Fumetobac; Habitrol; L-Nicotine; Mach-Nic; Niagara P.A. Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide; Nicoderm; Nicoderm Cq; Nicorette; Nicorette Plus; Nicotin; Nicotina; Nicotine; Nicotine Alkaloid; Nicotine Polacrilex; Nicotrol; Nicotrol Inhaler; Nicotrol Ns; Nikotin; Nikotyna; Ortho N-4 Dust; Ortho N-5 Dust; Prostep; Tendust; Tetrahydronicotyrine, Dl-; Xl All Insecticide

Dosage Forms
Gum, Inhaler, Patches

Absorption
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Interactions
Interactions for Nicotine:

Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.



Chemical IUPAC Name
3-(1-methylpyrrolidin-2-yl)pyridine

Chemical Formula
C10H14N2

Half Life
Cotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours

Drug Type
Approved Drug

# Accession No
APRD00200

CAS Registry Number
54-11-5

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